Capsule shields the function of short bacterial adhesins

Schembri, Mark A., Dalsgaard, Dorte and Klemm, Per (2004) Capsule shields the function of short bacterial adhesins. Journal of Bacteriology, 186 5: 1249-1257. doi:10.1128/JB.186.5.1249-1257.2004

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Author Schembri, Mark A.
Dalsgaard, Dorte
Klemm, Per
Title Capsule shields the function of short bacterial adhesins
Journal name Journal of Bacteriology   Check publisher's open access policy
ISSN 0021-9193
1098-5530
Publication date 2004-03
Sub-type Article (original research)
DOI 10.1128/JB.186.5.1249-1257.2004
Open Access Status File (Publisher version)
Volume 186
Issue 5
Start page 1249
End page 1257
Total pages 9
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Bacterial surface structures such as capsules and adhesins are generally regarded as important virulence factors. Here we demonstrate that capsules block the function of the self-recognizing protein antigen 43 through physical shielding. The phenomenon is not restricted to Escherichia coli but can occur in other gram-negative bacteria. Likewise, we show that other short adhesins exemplified by the AIDA-I protein are blocked by the presence of a capsule. The results support the notion that capsule polysaccharides sterically prevent receptor-target recognition of short bacterial adhesins. This negative interference has important biological consequences, such as affecting the ability of bacteria to form biofilms.
Keyword Microbiology
Escherichia-coli K-12
Urinary-tract-infections
Outer-membrane Protein
Antigen 43
Klebsiella-pneumoniae
Autotransporter Protein
Neisseria-meningitidis
Diffuse Adherence
Colony Morphology
Epithelial-cells
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 115 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 19 Sep 2007, 19:10:57 EST