Canine diabetes mellitus: can old dogs teach us new tricks?

Catchpole, B., Ristic, J. M., Fleeman, L. M. and Davison, L. J. (2005) Canine diabetes mellitus: can old dogs teach us new tricks?. Diabetologia, 48 10: 1948-1956. doi:10.1007/s00125-005-1921-1


Author Catchpole, B.
Ristic, J. M.
Fleeman, L. M.
Davison, L. J.
Title Canine diabetes mellitus: can old dogs teach us new tricks?
Journal name Diabetologia   Check publisher's open access policy
ISSN 0012-186X
1432-0428
Publication date 2005-10
Sub-type Article (original research)
DOI 10.1007/s00125-005-1921-1
Volume 48
Issue 10
Start page 1948
End page 1956
Total pages 9
Place of publication Berlin, Germany
Publisher Springer-Verlag
Language eng
Subject 0707 Veterinary Sciences
0799 Other Agricultural and Veterinary Sciences
Formatted abstract
Background
Diabetes is common in dogs, with an estimated prevalence of 0.32% in the UK. Clinical signs, as in man, include polydipsia, polyuria and weight loss, associated with hyperglycaemia and glucosuria. Diabetes typically occurs in dogs between 5 and 12 years of age, and is uncommon under 3 years of age. Breeds predisposed to diabetes include the Samoyed, Tibetan Terrier and Cairn Terrier, while others such as the Boxer and German Shepherd Dog seem less susceptible. These breed differences suggest a genetic component, and at least one dog leucocyte antigen haplotype (DLA DRB1*009, DQA1*001, DQB1*008) appears to be associated with susceptibility to diabetes.

Methods

Canine diabetes can be classified into insulin deficiency diabetes (IDD), resulting from a congenital deficiency or acquired loss of pancreatic beta cells, or insulin resistance diabetes resulting mainly from hormonal antagonism of insulin function.

Results

There is no evidence for a canine equivalent of human type 2 diabetes. Adult-onset IDD, requiring insulin therapy, is the most common form, with pancreatitis and/or immune-mediated beta cell destruction considered to be the major underlying causes of the disease.

Discussion
Autoantibodies to insulin, recombinant canine GAD65 and/or canine islet antigen-2 have been identified in a proportion of newly diagnosed diabetic dogs, suggesting that autoimmunity is involved in the pathogenesis of disease in some patients.

Conclusion

The late onset and slow progression of beta cell dysfunction in canine diabetes resembles latent autoimmune diabetes of the adult in man. 
Keyword Autoantibodies
Dog
Dog leucocyte antigen
Endocrine diseases
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 63 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 67 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 27 Mar 2006, 20:36:02 EST