Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging

Zhang, Jiangyang, Richards, Linda J, Yarowsky, Paul, Huang, Hao, van Zijl, Peter C. M and Mori, Susumu (2003) Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging. Neuroimage, 20 3: 1639-1648. doi:10.1016/S1053-8119(03)00410-5


Author Zhang, Jiangyang
Richards, Linda J
Yarowsky, Paul
Huang, Hao
van Zijl, Peter C. M
Mori, Susumu
Title Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2003
Sub-type Article (original research)
DOI 10.1016/S1053-8119(03)00410-5
Volume 20
Issue 3
Start page 1639
End page 1648
Total pages 10
Place of publication San Diego
Publisher Academic Press Inc Elsevier Science
Language eng
Subject 1702 Cognitive Sciences
1103 Clinical Sciences
1109 Neurosciences
Abstract Investigation of three-dimensional (3D) morphometry of developing brains has been hindered by a lack of imaging modalities that can monitor the 3D evolution of various anatomical structures without sectioning and staining processes. In this study, we combined magnetic resonance microimaging and diffusion tensor imaging techniques to accomplish such visualization. The application of this approach to developing mouse embryos revealed that it could clearly delineate early critical structures such as neuroepithelium, cortical plate, and various axonal structures, and follow their developmental evolution. The technique was applied to the study of the Netrin-1 mutant, allowing verification of its anatomical phenotype. (C) 2003 Elsevier Inc. All rights reserved.
Keyword Neurosciences
Neuroimaging
Radiology, Nuclear Medicine & Medical Imaging
Magnetic-resonance Microscopy
Anisotropic Water Diffusion
Gene-expression
Axonal Projections
Neuronal Migration
Nervous-system
Tracking
Visualization
Tomography
Netrin-1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Created: Wed, 19 Sep 2007, 17:35:50 EST