Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development

Gu, C. H., Rodriguez, E. R., Reimert, D. V., Shu, T. Z., Fritzsch, B., Richards, L. J., Kolodkin, A. L. and Ginty, D. D. (2003) Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Developmental Cell, 5 1: 45-57. doi:10.1016/S1534-5807(03)00169-2


Author Gu, C. H.
Rodriguez, E. R.
Reimert, D. V.
Shu, T. Z.
Fritzsch, B.
Richards, L. J.
Kolodkin, A. L.
Ginty, D. D.
Title Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
Journal name Developmental Cell   Check publisher's open access policy
ISSN 1534-5807
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1016/S1534-5807(03)00169-2
Volume 5
Issue 1
Start page 45
End page 57
Total pages 13
Place of publication Cambridge
Publisher Cell Press
Language eng
Abstract Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). We generated npn-1 knockin mice, which express an altered ligand binding site variant of Npn-1, and npn-1 conditional null mice to establish the cell-type- and ligand specificity of Npn-1 function in the developing cardiovascular and nervous systems. Our results show that VEGF-Npn-1 signaling in endothelial cells is required for angiogenesis. In striking contrast, Sema-Npn-1 signaling is not essential for general vascular development but is required for axonal pathfinding by several populations of neurons in the CNS and PNS. Remarkably, both Sema-Npn-1 signaling and VEGF-Npn-1 signaling are critical for heart development. Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system.
Keyword Cell Biology
Developmental Biology
Endothelial Growth-factor
Peripheral-nerve Projection
Stimulates Axonal Outgrowth
Secreted Semaphorins
Transgenic Mice
In-vivo
Receptor
Angiogenesis
Guidance
Cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Created: Thu, 20 Sep 2007, 03:55:26 EST