Application of the new EPR spin trap 1,1,3-trimethylisoindole N-oxide (TMINO) in trapping HO. and related biologically important radicals

Bottle, Steven E., Hanson, Graeme R. and Micallef, Aaron S. (2003) Application of the new EPR spin trap 1,1,3-trimethylisoindole N-oxide (TMINO) in trapping HO. and related biologically important radicals. Organic & Biomolecular Chemistry, 1 14: 2585-2589. doi:10.1039/b300644a


Author Bottle, Steven E.
Hanson, Graeme R.
Micallef, Aaron S.
Title Application of the new EPR spin trap 1,1,3-trimethylisoindole N-oxide (TMINO) in trapping HO. and related biologically important radicals
Formatted title
Application of the new EPR spin trap 1,1,3-trimethylisoindole N-oxide (TMINO) in trapping HO. and related biologically important radicals
Journal name Organic & Biomolecular Chemistry   Check publisher's open access policy
ISSN 1477-0520
Publication date 2003
Sub-type Article (original research)
DOI 10.1039/b300644a
Open Access Status Not Open Access
Volume 1
Issue 14
Start page 2585
End page 2589
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract The new EPR spin trap, 1,1,3-trimethylisoindole N-oxide (TMINO), very efficiently scavenges several Fenton-derived carbon- and oxygen-centred radicals including hydroxyl, formyl and alkyl radicals. The adducts display good stability and narrow EPR line-widths, allowing the detection of the expected radicals as well as two-dimensional (time-resolved) EPR experiments. Trapping experiments were also undertaken with superoxide radicals (giving no EPR signals) and nitric oxide (which gave strong EPR signals attributed to the action of higher oxides of nitrogen). The selectivity of TMINO towards HO. with respect to superoxide radicals demonstrates its potential as a useful spin-trap.
Keyword Chemistry, Organic
Mammalian-cells
Nitric-oxide
Rat-kidney
Hydroxyl
Reperfusion
Spectroscopy
Neutrophils
Nitroxides
Superoxide
Ischemia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Advanced Imaging Publications
 
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Created: Wed, 19 Sep 2007, 18:37:22 EST