A ballistic study of micro-particle penetration to the oral mucosa

Mitchell, Thomas J., Kendall, Mark A. F. and Bellhouse, Brian J. (2003) A ballistic study of micro-particle penetration to the oral mucosa. International Journal of Impact Engineering, 28 6: 581-599.


Author Mitchell, Thomas J.
Kendall, Mark A. F.
Bellhouse, Brian J.
Title A ballistic study of micro-particle penetration to the oral mucosa
Journal name International Journal of Impact Engineering   Check publisher's open access policy
ISSN 0734-743X
Publication date 2003-07
Sub-type Article (original research)
DOI 10.1016/S0734-743X(02)00150-1
Volume 28
Issue 6
Start page 581
End page 599
Total pages 19
Place of publication Oxford
Publisher Elsevier Science Ltd.
Language eng
Abstract This paper describes the results of an investigation into the impact of model micro-particles to ex vivo buccal mucosa (the cheek) of pigs and beagle dogs. The work is aimed at optimizing a unique form of pharmaceutical delivery. The pharmaceutical is formulated into particle form and accelerated toward the target of skin or mucosa by using a gas jet. In this study, research devices designed using analytical, computational (computational fluid dynamics) and experimental methodologies were used to deliver particles at uniform and predetermined velocities. These velocities were confirmed using light obscuration, pressure measurement and particle image velocimetry methods. Polystyrene, glass, stainless steel and gold micro-particles at a range of size distributions were used for the payloads for injection using these devices. Injection occurred with a wide range of impact conditions into fresh canine (dog) and porcine (pig) buccal mucosa. Final positions of the particles were determined from histological sections and the results analyzed in relation to the known particle impact parameters of size, density and velocity. The experimental results are collated using an empirical term, based on particle impact parameters. Comparison is then made to a semi-empirical penetration model. This is done by analysing the penetration results in terms of each particle impact parameter. Analysis shows that this model fits the experimental data well when reasonable estimates of the tissue mechanical properties are chosen. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keyword Engineering, Mechanical
Mechanics
powder injection
biolistics
penetration
mucosa
Drug-delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 347 Abstract Views  -  Detailed Statistics
Created: Wed, 19 Sep 2007, 15:04:11 EST