Cancellous bone microdamage in the proximal femur: Influence of age and osteoarthritis on damage morphology and regional distribution

Fazzalari, N. L., Kuliwaba, J. S. and Forwood, M. R. (2002) Cancellous bone microdamage in the proximal femur: Influence of age and osteoarthritis on damage morphology and regional distribution. Bone, 31 6: 697-702. doi:10.1016/S8756-3282(02)00906-7


Author Fazzalari, N. L.
Kuliwaba, J. S.
Forwood, M. R.
Title Cancellous bone microdamage in the proximal femur: Influence of age and osteoarthritis on damage morphology and regional distribution
Journal name Bone   Check publisher's open access policy
ISSN 8756-3282
Publication date 2002
Sub-type Article (original research)
DOI 10.1016/S8756-3282(02)00906-7
Volume 31
Issue 6
Start page 697
End page 702
Total pages 6
Place of publication New York
Publisher Elsevier Science Inc
Collection year 2002
Language eng
Subject C1
321017 Orthopaedics
730114 Skeletal system and disorders (incl. arthritis)
Abstract This study describes the in vivo distribution of cancellous bone microdamage in the proximal femur of an autopsy control sample. In addition, in vivo microdamage in the region medial to the greater trochanter of the proximal femur is compared between patients with severe osteoarthritis and controls. Taken at autopsy, the control group comprised normal right proximal femora that were then cut in the coronal plane with an Exakt saw (n = 12; aged 20-83 years). Cancellious bone samples were taken from the subchondral principal compressive region, the medial principal compressive region, and medial to the greater trochanter (of the proximal femur) from patients with primary osteoarthritis under-going total hip replacement surgery (n = 33; aged 37-85 years). Samples were embedded in resin, and in vivo microdamage identified in 70-mum-thick sections using the basic fuchsin en bloc staining technique. Microdamage was similar in all proximal femur sites in controls, except in the subchondral principal compressive region, where a significantly smaller crack length (mum) was identified (p < 0.05). In the region medial to the greater trochanter, osteoarthritic vs. control group comparisons showed that the crack density (#/mm(2)) and crack surface density (mm/mm(2)) were not significantly different, but crack length was significantly less (p < 0.03) and damage volume fraction was significantly increased for osteoarthritics (p <0.005). The osteoarthritic and control data for crack density, and the osteoarthritic data for damage volume fraction, showed a nonlinear increase with age. Furthermore, crack length was not dependent on damage volume fraction or age for either the osteoarthritic or control group. This study identified differences in microdamage between osteoarthritic and autopsy control cases. We hypothesize that these results are consistent with the reported bone material property differences for osteoarthritis. In addition, the relatively uniform distribution of microdamage in the control group suggests that the principal components of the femoral cancellous bone network are equally exposed to ileforipaii.ons resulting in microdamage. Further study into the factors that influence the accumulation and skeletal distribution of microdamage is fundamental to und,erstandi,na skeletal health. (C) 2002 by Elsevier Science Inc. All rights reserved.
Keyword Endocrinology & Metabolism
proximal femur microdamage
trabecular bone microdamage
crack density
damage volume fraction
osteoarthritis
Compact-bone
Mechanical-properties
Cortical Bone
In-vivo
Biomechanical Properties
Trabecular Bone
Femoral-neck
Accumulation
Fatigue
Osteoporosis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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