Life cycle heterogeneity in animal models of human papillomavirus-associated disease

Peh, Woei Ling, Middleton, Kate, Christensen, Neil, Nicholls, Philip, Egawa, Kiyofumi, Sotlar, Karl, Brandsma, Janet, Percival, Alan, Lewis, Jon, Liu, Wen Jun and Doorbar, John (2002) Life cycle heterogeneity in animal models of human papillomavirus-associated disease. Journal of Virology, 76 20: 10401-10416. doi:10.1128/JVI.76.20.10401-10416.2002

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Author Peh, Woei Ling
Middleton, Kate
Christensen, Neil
Nicholls, Philip
Egawa, Kiyofumi
Sotlar, Karl
Brandsma, Janet
Percival, Alan
Lewis, Jon
Liu, Wen Jun
Doorbar, John
Title Life cycle heterogeneity in animal models of human papillomavirus-associated disease
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2002-10-01
Year available 2002
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1128/JVI.76.20.10401-10416.2002
Open Access Status File (Publisher version)
Volume 76
Issue 20
Start page 10401
End page 10416
Total pages 16
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Animal papillomaviruses are widely used as models to study papillomavirus infection in humans despite differences in genome organization and tissue tropism. Here, we have investigated the extent to which animal models of papillomavirus infection resemble human disease by comparing the life cycles of 10 different papillomavirus types. Three phases in the life cycles of all viruses were apparent using antibodies that distinguish between early events, the onset of viral genome amplification, and the expression of capsid proteins. The initiation of these phases follows a highly ordered pattern that appears important for the production of virus particles. The viruses examined included canine oral papillomavirus, rabbit oral papillomavirus (ROPV), cottontail rabbit papillomavirus (CRPV), bovine papillomavirus type 1, and human papillomavirus types 1, 2, 11, and 16. Each papillomavirus type showed a distinctive gene expression pattern that could be explained in part by differences in tissue tropism, transmission route, and persistence. As the timing of life cycle events affects the accessibility of viral antigens to the immune system, the ideal model system should resemble human mucosal infection if vaccine design is to be effective. Of the model systems examined here, only ROPV had a tissue tropism and a life cycle organization that resembled those of the human mucosal types. ROPV appears most appropriate for studies of the life cycles of mucosal papillomavirus types and for the development of prophylactic vaccines. The persistence of abortive infections caused by CRPV offers advantages for the development of therapeutic vaccines.
Keyword Virology
Cottontail Rabbit Papillomavirus
Intracytoplasmic Inclusion-bodies
Late Gene-expression
Open Reading Frame
Bovine Papillomavirus
Condylomata Acuminata
In-vivo
Intracutaneous Vaccination
E1-boolean-and-e4 Protein
Spontaneous Regression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Wed, 19 Sep 2007, 15:41:43 EST