A comparison of antibiotic susceptibility testing methods for cotrimoxazole with Burkholderia pseudomallei

Peter Piliouras, Ulett, Glen C., Ashhurst-Smith, Christopher, Hirst, Robert G. and Norton, Robert E. (2002) A comparison of antibiotic susceptibility testing methods for cotrimoxazole with Burkholderia pseudomallei. International Journal of Antimicrobial Agents, 19 5: 427-429.


Author Peter Piliouras
Ulett, Glen C.
Ashhurst-Smith, Christopher
Hirst, Robert G.
Norton, Robert E.
Title A comparison of antibiotic susceptibility testing methods for cotrimoxazole with Burkholderia pseudomallei
Journal name International Journal of Antimicrobial Agents   Check publisher's open access policy
ISSN 0924-8579
1872-7913
Publication date 2002-05
Sub-type Article (original research)
DOI 10.1016/S0924-8579(02)00016-X
Volume 19
Issue 5
Start page 427
End page 429
Total pages 3
Place of publication Amsterdam, Netherlands
Publisher Elsevier Science Bv
Language eng
Subject 0304 Medicinal and Biomolecular Chemistry
Abstract Melioidosis is caused by the Gram-negative soil saprophyte, Burkholderia pseudomallei and is endemic in tropical and subtropical regions of southeast Asia and northern Australia. Cotrimoxazole has been traditionally used for the therapy of melioidosis despite results indicating resistance often produced in the disc diffusion test against B. pseudomallei. This inconsistency was addressed by comparing this method with the agar dilution, Microscan and E-test methods. The results demonstrated that by disc diffusion, 41.3% of 80 B. pseudomallei clinical isolates tested were susceptible to cotrimoxazole, whereas the Microscan, agar dilution and the, E-test demonstrated 92.5, 90 and 97.5% of the isolates to be susceptible, respectively. These results indicate that an MIC based method is required to test the susceptibility of B. pseudomallei against cotrimoxazole. (C) 2002 Published by Elsevier Science B.V. and International Society of Chemotherapy.
Keyword Infectious Diseases
Microbiology
Pharmacology & Pharmacy
Burkholderia pseudomallei
melioidosis
cotrimoxazole
susceptibility
Melioidosis
Chloramphenicol
Doxycycline
Queensland
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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