Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice

Ulett, Glen C., Ketheesan, Natkunam, Clair, Timothy W., McElnea, Catriona L., Barnes, Jodie L. and Hirst, Robert G. (2002) Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice. Infection And Immunity, 70 7: 3953-3958. doi:10.1128/IAI.70.7.3953-3958.2002

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Author Ulett, Glen C.
Ketheesan, Natkunam
Clair, Timothy W.
McElnea, Catriona L.
Barnes, Jodie L.
Hirst, Robert G.
Title Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice
Journal name Infection And Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 2002-07
Sub-type Article (original research)
DOI 10.1128/IAI.70.7.3953-3958.2002
Open Access Status File (Publisher version)
Volume 70
Issue 7
Start page 3953
End page 3958
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Cytokine mRNA levels were assessed in Burkholderia pseudomallei-suseeptible BALB/c mice and B. pseudomallei-resistant C57BL/6 mice following administration of a sublethal dose of less virulent (LV) B. pseudomallei, a candidate immunogen tested for protection against a highly virulent (HV) challenge. Compared on the basis of the bacterial loads, the cytokine patterns induced by RV and LV B. pseudomallei were similar, involving gamma interferon, interleukin-10, and other cytokines. Partial cross-protection between B. pseudomallei strains is shown to be associated with cytokine profiles involving both type 1 and type 2 cytokines.
Keyword Immunology
Infectious Diseases
Tumor-necrosis-factor
Factor-alpha
Gamma-interferon
Mycobacterium-avium
Trypanosoma-cruzi
Gene-expression
Infected Mice
Murine Model
C57bl/6 Mice
Ifn-gamma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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