Development of the perforating pathway: An ipsilaterally projecting pathway between the medial septum/diagonal band of broca and the cingulate cortex that intersects the corpus callosum

Shu, T. Z., Shen, W. B. and Richards, L. J. (2001) Development of the perforating pathway: An ipsilaterally projecting pathway between the medial septum/diagonal band of broca and the cingulate cortex that intersects the corpus callosum. Journal of Comparative Neurology, 436 4: 411-422. doi:10.1002/cne.1077


Author Shu, T. Z.
Shen, W. B.
Richards, L. J.
Title Development of the perforating pathway: An ipsilaterally projecting pathway between the medial septum/diagonal band of broca and the cingulate cortex that intersects the corpus callosum
Journal name Journal of Comparative Neurology   Check publisher's open access policy
ISSN 0021-9967
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1002/cne.1077
Volume 436
Issue 4
Start page 411
End page 422
Total pages 12
Place of publication New York
Publisher Wiley-liss
Language eng
Abstract The perforating pathway (PFP) intersects the corpus callosum perpendicularly at the midline in the dorsoventral axis. Therefore axons in either the PFP or the corpus callosum make different axonal guidance decisions in the same anatomical region of the developing cortical midline. The mechanisms underlying these axonal choices are not known. To begin to identify these guidance mechanisms, we characterized the development of these two pathways in detail. The development of the corpus callosum and its pioneering projections has been described elsewhere (Shu and Richards [2001] J. Neurosci. 21:2749-2758; Rash and Richards [2001] J. Comp. Neurol. 434:147-157). Here we examine the development, origins, and projections of axons that make up the PFP. The majority of axons within the PFP originate from neurons in the medial septum and diagonal band of Broca complex. These neurons project in a topographic manner to the cingulate cortex. In contrast to previous reports, we find that a much smaller projection originating from the cingulate cortex also contributes to this pathway. The pioneering projections of the PFP and the corpus callosum arrive at the corticoseptal boundary at around the same developmental stage. These findings show that ipsilaterally projecting PFP axone and contralaterally projecting callosal axons make distinct guidance decisions at the same developmental stage when they reach the corticoseptal boundary. J. Comp. Neurol. 436:411-422, 2001. (C) 2001 Wiley-Liss. Inc.
Keyword Neurosciences
Zoology
neocortex
septum
cortico-septal boundary
midline
glial wedge
glial sling
DiI
Phaseolus-vulgaris Leucoagglutinin
Mouse Optic Chiasm
Basal Forebrain
Axon Guidance
Nervous-system
Choline-acetyltransferase
Cortical Projections
Cerebral-cortex
Developing Rat
Diagonal Band
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Thu, 20 Sep 2007, 01:50:57 EST