Acute Disseminated Encephalomyelitis

Pender, Michael P. (1995). Acute Disseminated Encephalomyelitis. In Pender, Michael P. and McCombe, Pamela A. (Ed.), Autoimmune Neurological Disease (pp. 155-165) Cambridge, UK: Cambridge University Press.

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Author Pender, Michael P.
Title of chapter Acute Disseminated Encephalomyelitis
Title of book Autoimmune Neurological Disease
Place of Publication Cambridge, UK
Publisher Cambridge University Press
Publication Year 1995
Editor Pender, Michael P.
McCombe, Pamela A.
Chapter number 5
Start page 155
End page 165
Subjects 321013 Neurology and Neuromuscular Diseases
320207 Autoimmunity
Abstract/Summary Acute disseminated encephalomyelitis (ADEM) (post-infectious encephalomyelitis or post-vaccinal encephalomyelitis) is an acute inflammatory demyelinating disease of the central nervous system (CNS). Typically it follows infection by a virus, but it may also follow infection by other agents or may complicate vaccination. Sometimes it occurs without any obvious triggering factors. The clinical manifestations are diverse and include presentation with acute transverse myelitis. Acute haemhorrhagic leukoencephalitis is a rare and more severe form of ADEM with a high mortality and morbidity. There is good evidence that ADEM and acute haemhorrhagic leukoencephalitis are autoimmune diseases similar to acute experimental autoimmune encephalomyelitis (EAE) and hyperacute EAE repectively.
Keyword Acute disseminated encephalomyelitis
autoimmune diseases
central nervous system
acute haemhorrhagic leukoencephalitis
Additional Notes Reproduced from Pender, Michael P. and McCombe, Pamela A. (1995) Autoimmune Neurological Disease, Cambridge: Cambridge University Press, 1995, with permission.

Document type: Book Chapter
Collection: School of Medicine Publications
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Created: Fri, 30 Apr 2004, 10:00:00 EST