A controlled exercise training trial in patients with diastolic dysfunction

Smart, N. A., Ritchie, C. B., Haluska, B. A. and Marwick, T. H. (2006). A controlled exercise training trial in patients with diastolic dysfunction. In: Frans Van De Werf, European Heart Journal: abstracts of the World Congress of Cardiology. World Congress of Cardiology, Barcelona, Spain, (102-102). 2-6 September, 2006.


Author Smart, N. A.
Ritchie, C. B.
Haluska, B. A.
Marwick, T. H.
Title of paper A controlled exercise training trial in patients with diastolic dysfunction
Conference name World Congress of Cardiology
Conference location Barcelona, Spain
Conference dates 2-6 September, 2006
Proceedings title European Heart Journal: abstracts of the World Congress of Cardiology   Check publisher's open access policy
Journal name European Heart Journal   Check publisher's open access policy
Place of Publication Oxford, UK
Publisher Oxford University Press
Publication Year 2006
ISSN 1522-9645
0195-668X
Editor Frans Van De Werf
Volume 27
Issue Supplement
Start page 102
End page 102
Total pages 1
Language eng
Formatted Abstract/Summary Background:
Exercise training (ExT) improves functional capacity in systolic
heart failure, but the role of ExT in diastolic dysfunction patients (DD) is unclear.

Methods:

Twenty four DD patients were randomized to ExT or normal treatment.
ExT was completed in 15 patients (8 men, 63±4 years, LVEF 55±9%) 9 DD
patients undertook usual treatment (7 men, 58±8 years, LVEF 57±7%). Peak
VO2, quality of life QOL; Minnesota Living with Heart Failure [MLWHF] and Hare-
Davis [HD] questionnaires) and echo measures (EF, systolic [Sm] and diastolic
tissue velocity [Em] and filling pressure [E/E’]) were performed at baseline and 16
weeks ExT.

Results:

Both groups showed similar baseline VO2 (13.2±5.8 vs 16.4±4.2
mls/kg/min, p=0.16), Sm (5.2±1.2 vs 6.0±0.9 cm/s, p=0.10) and E/E’ (21.6±12
vs 11.2±10, p=0.12) but different Em (3.7±3.8 cm/s vs 6.6±1.6, p=0.04). Baseline
MLWHF and HD scores were similar in both groups, change in the total
(p=0.01) and emotional (p=0.006) dimensions of MLWHF and HD (p=0.05) scores
were significantly improved at 12 weeks in ExT patients. After ExT, the increment
in peak VO2 was significantly greater in ExT (27%) versus control group (3%),
(p=0.02).

Conclusions:

In patients with exercise limitation attributed to DD, the improvement
in peak VO2 and QOL with ExT is similar to those with SD, but unrelated to
changes in diastolic function.
Subjects EX
110201 Cardiology (incl. Cardiovascular Diseases)
110299 Cardiovascular Medicine and Haematology not elsewhere classified
Q-Index Code EX

 
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