A controlled exercise training trial in patients with diastolic dysfunction

Smart, Neil A., Haluska, Brian, Ritchie, Carrie and Marwick, Thomas H. (2006). A controlled exercise training trial in patients with diastolic dysfunction. In: A. N. DeMaria, Journal of the American College of Cardiology: ACC.06 Abstracts. 55th Annual Scientific Sessions, Atlanta, USA, (155A-155A). 11-14 March, 2006. doi:10.1016/j.jacc.2006.01.013

Author Smart, Neil A.
Haluska, Brian
Ritchie, Carrie
Marwick, Thomas H.
Title of paper A controlled exercise training trial in patients with diastolic dysfunction
Conference name 55th Annual Scientific Sessions
Conference location Atlanta, USA
Conference dates 11-14 March, 2006
Proceedings title Journal of the American College of Cardiology: ACC.06 Abstracts   Check publisher's open access policy
Journal name Journal of the American College of Cardiology   Check publisher's open access policy
Place of Publication New York
Publisher Elsevier Science Publishing
Publication Year 2006
Sub-type Poster
DOI 10.1016/j.jacc.2006.01.013
ISSN 0735-1097
Editor A. N. DeMaria
Volume 47
Issue 4, Supplement 1
Start page 155A
End page 155A
Total pages 1
Language eng
Formatted Abstract/Summary
Exercise training (ExT) improves functional capacity in systolic heart
failure, but the role of ExT in diastolic dysfunction patients (DD) is unclear.

Twenty four DD patients were randomized to ExT or normal treatment. ExT was
completed in 15 patients (8 men, 63±4 years, LVEF 55±9%) 9 DD patients undertook
usual treatment (7 men, 58±8 years, LVEF 57±7%). Peak VO2, quality of life QOL;
Minnesota Living with Heart Failure [MLWHF] and Hare-Davis [HD] questionnaires) and
echo measures (EF, systolic [Sm] and diastolic tissue velocity [Em] and filling pressure
[E/E’]) were performed at baseline and 16 weeks ExT.

Both groups showed similar baseline VO2 (13.2±5.8 vs 16.4±4.2 mls/kg/min,
p=0.16), Sm (5.2±1.2 vs 6.0±0.9 cm/s, p=0.10) and E/E’ (21.6±12 vs 11.2±10, p=0.12)
but different Em (3.7±3.8 cm/s vs 6.6±1.6, p=0.04). Baseline MLWHF and HD scores
were similar in both groups. After ExT, the increment in peak VO2 was significantly greater
in ExT (27%) versus control group (3%, p=0.02). Increment in peak VO2 was predicted by
baseline E and A wave velocity (r =0.87, p<0.001), but not by changes in echo parameters.
The only echo parameter which responded to training was contractile reserve (p=0.02)
versus usual treatment group. At 12 weeks, there was a significant improvement in the
total (p=0.01) and emotional (p=0.006) dimensions of MLWHF and HD (p=0.05) scores .


In patients with exercise limitation attributed to DD, there is a significant
improvement in peak VO2 and QOL with ExT, in addition to usual medical therapy. This
improvement appears unrelated to changes in diastolic function.
Subjects EX
110201 Cardiology (incl. Cardiovascular Diseases)
110299 Cardiovascular Medicine and Haematology not elsewhere classified
Q-Index Code EX
Additional Notes Diagnostic Testing: Poster session

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Created: Thu, 23 Aug 2007, 21:47:22 EST