Survival And Mitosis Of Myelinating Oligodendrocytes In Experimental Autoimmune Encephalomyelitis: An Immunocytochemical Study With Rip Antibody

Nguyen, Kim B. and Pender, Michael P. (1999) Survival And Mitosis Of Myelinating Oligodendrocytes In Experimental Autoimmune Encephalomyelitis: An Immunocytochemical Study With Rip Antibody. Acta Neuropathologica, 98 1: 39-47. doi:10.1007/s004010051049

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Author Nguyen, Kim B.
Pender, Michael P.
Title Survival And Mitosis Of Myelinating Oligodendrocytes In Experimental Autoimmune Encephalomyelitis: An Immunocytochemical Study With Rip Antibody
Journal name Acta Neuropathologica   Check publisher's open access policy
ISSN 0001-6322
Publication date 1999-07-01
Sub-type Article (original research)
DOI 10.1007/s004010051049
Open Access Status File (Author Post-print)
Volume 98
Issue 1
Start page 39
End page 47
Total pages 9
Place of publication New York, USA
Publisher Springer Verlag
Language eng
Subject 320207 Autoimmunity
321013 Neurology and Neuromuscular Diseases
Abstract The fate of myelin-forming oligodendrocytes in the spinal cord of Lewis rats with acute and chronic relapsing experimental autoimmune encephalomyelitis (EAE) was studied using the pre-embedding immunolabelling technique with the Rip monoclonal antibody which specifically labels the cytoplasm of the cell body and processes of the mature oligodendrocyte. Morphologically normal Rip-positive (Rip+) cells were found in close contact with demyelinated axons at the onset of demyelination and during the course of disease, indicating that oligodendrocytes survive the acute demyelinating insult. Occasional Rip+ oligodendrocytes were undergoing mitosis at the time of onset of neurological signs. These mitotic oligodendrocytes were present in both the grey and white matter. The majority of the mitotic oligodendrocytes had processes in direct contact with myelin sheaths for considerable lengths, indicating that they were myelinating cells. This study indicates that oligodendrocytes survive the acute demyelinating insult in EAE and that mature myelinating oligodendrocytes are able to undergo mitosis.
Keyword experimental autoimmune encephalomyelitis
demyelination
mitosis
oligodendrocyte
Rip antibody
experimental allergic encephalomyelitis
EAE
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This is an author version of an article originally published as Nguyen, K.B. and M.P. Pender, Survival And Mitosis Of Myelinating Oligodendrocytes In Experimental Autoimmune Encephalomyelitis: An Immunocytochemical Study With Rip Antibody. Acta Neuropathol (Berl), 1999. 98(1): 39-47, with permission. DOI: 10.1007/s004010051049 Copyright Springer-Verlag 1999. All rights reserved. The original publication is available from www.springerlink.com.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 27 Jul 2004, 10:00:00 EST