Phagocytosis of Apoptotic Lymphocytes by Oligodendrocytes In experimental Autoimmune Encephalomyelitis

Nguyen, Kim B. and Pender, Michael P. (1998) Phagocytosis of Apoptotic Lymphocytes by Oligodendrocytes In experimental Autoimmune Encephalomyelitis. Acta Neuropathologica, 95 1: 40-46. doi:10.1007/s004010050763

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Author Nguyen, Kim B.
Pender, Michael P.
Title Phagocytosis of Apoptotic Lymphocytes by Oligodendrocytes In experimental Autoimmune Encephalomyelitis
Journal name Acta Neuropathologica   Check publisher's open access policy
ISSN 0001-6322
Publication date 1998-01-01
Sub-type Article (original research)
DOI 10.1007/s004010050763
Open Access Status File (Author Post-print)
Volume 95
Issue 1
Start page 40
End page 46
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Subject 320207 Autoimmunity
321013 Neurology and Neuromuscular Diseases
Abstract The alterations in oligodendrocytes in myelin basic protein-induced acute experimental autoimmune encephalomyelitis (EAE) in the Lewis rat were studied using the technique of pre-embedding immunolabelling with the Rip monoclonal antibody, which specifically labels the cytoplasm of the cell bodies and processes of oligodendrocytes. In spinal cord sections of untreated and dexamethasone- treated rats with EAE, we found that apoptotic lymphocytes were phagocytosed by Rip-positive oligodendrocytes as well as by CD11b/c-positive macrophages/ microglia and by astrocytes expressing glial fibrillary acidic protein. Morphologically normal lymphocytes were also internalised by these cell types, a phenomenon known as emperipolesis. We suggest that this phenomenon represents the phagocytosis of lymphocytes that have undergone the plasma membrane alterations of apoptosis without yet manifesting the nuclear condensation of apoptosis. We also found an increase in the number of clusters of two to four oligodendrocytes, mainly in the grey matter, suggesting proliferation of cells of the oligodendrocyte lineage.
Keyword Apoptosis
Experimental autoimmune encephalomyelitis
Experimental allergic encephalomyelitis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes This is an author version of an article originally published as Nguyen, K.B. and M.P. Pender, Phagocytosis Of Apoptotic Lymphocytes By Oligodendrocytes In Experimental Autoimmune Encephalomyelitis. Acta Neuropathol (Berl), 1998. 95(1): 40-6, with permission. DOI : 10.1007/s004010050763 Copyright Springer-Verlag 1998. The original publication is available at

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
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Created: Tue, 27 Jul 2004, 10:00:00 EST