Cholesterol, Bile Acid, And Lipoprotein Metabolism In Two Strains Of Hamster, One Resistant, The Other Sensitive (LPN) To Sucrose-Induced Cholelithiasis

Ferezou, Jacqueline, Combettes-Souverain, Murielle, Souidi, Maamar, Smith, Jeffery L., Boehler, Nathalie, Milliat, Fabien, Eckhardt, Erik, Blanchard, Geraldine, Riottot, Michel, Serougne, Colette and Lutton, Claude (2000) Cholesterol, Bile Acid, And Lipoprotein Metabolism In Two Strains Of Hamster, One Resistant, The Other Sensitive (LPN) To Sucrose-Induced Cholelithiasis. Journal of Lipid Research, 41 12: 2042-2054.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ10221_OA.pdf Full text (open access) application/pdf 297.12KB 12
jls_jlr_41_12_00.pdf jls_jlr_41_12_00.pdf application/pdf 21.17KB 219
Author Ferezou, Jacqueline
Combettes-Souverain, Murielle
Souidi, Maamar
Smith, Jeffery L.
Boehler, Nathalie
Milliat, Fabien
Eckhardt, Erik
Blanchard, Geraldine
Riottot, Michel
Serougne, Colette
Lutton, Claude
Title Cholesterol, Bile Acid, And Lipoprotein Metabolism In Two Strains Of Hamster, One Resistant, The Other Sensitive (LPN) To Sucrose-Induced Cholelithiasis
Journal name Journal of Lipid Research   Check publisher's open access policy
ISSN 0022-2275
Publication date 2000-12-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 41
Issue 12
Start page 2042
End page 2054
Total pages 13
Language eng
Subject 321006 Gastroenterology and Hepatology
Abstract A comprehensive study of cholesterol, bile acid, and lipoprotein metabolism was undertaken in two strains of hamster that differed markedly in their response to a sucrose-rich/low fat diet. Under basal conditions, hamsters from the LPN strain differed from Janvier hamsters by a lower cholesterolemia, a higher postprandial insulinemia, a more active cholesterogenesis in both liver [3- to 4-fold higher 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR) activity and mRNA] and small intestine, and a lower hepatic acyl-coenzyme A:cholesterol acyltransferase activity. Cholesterol saturation indices in the gallbladder bile were similar for both strains, but the lipid concentration was 2-fold higher in LPN than in Janvier hamsters. LPN hamsters had a lower capacity to transform cholesterol into bile acids, shown by the smaller fraction of endogenous cholesterol converted into bile acids prior to fecal excretion (0.34 vs. 0.77). In LPN hamsters, the activities of cholesterol 7 -hydroxylase (C7OHase) and sterol 27-hydroxylase (S27OHase), the two rate-limiting enzymes of bile acid synthesis, were disproportionably lower (by 2-fold) to that of HMG-CoAR. When fed a sucrose-rich diet, plasma lipids increased, dietary cholesterol absorption improved, hepatic activities of HMG-CoA reductase, C7Ohase, and S27OHase were reduced, and intestinal S27OHase was inhibited in both strains. Despite a similar increase in the biliary hydrophobicity index due to the bile acid enrichment in chenodeoxycholic acid and derivatives, only LPN hamsters had an increased lithogenic index and developed cholesterol gallstones (75% incidence), whereas Janvier hamsters formed pigment gallstones (79% incidence). These studies indicate that LPN hamsters have a genetic predisposition to sucrose-induced cholesterol gallstone formation related to differences in cholesterol and bile acid metabolism.
Keyword bile
SR-BI
sterol 27-hydroxylase
cholesterol 7alpha-hydroxylase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This article is abstract only. The full text of the article can be downloaded from the JLR web site (http://www.jlr.org/cgi/content/full/41/12/2042).

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 26 Nov 2004, 10:00:00 EST