Reduction in scar thickness post myocardial infarction is secondary to increase in regional left ventricular volumes

Chan, J., Du, L., Strudwick, M. W. and Marwick, T. H. (2005). Reduction in scar thickness post myocardial infarction is secondary to increase in regional left ventricular volumes. In: Frans Van de Werf, European Heart Journal: Abstracts selected for presentation at the European Society of Cardiology Congress. European Society of Cardiology Congress, Stockholm , Sweden, (139-139). 3rd - 7th September, 2005.

Author Chan, J.
Du, L.
Strudwick, M. W.
Marwick, T. H.
Title of paper Reduction in scar thickness post myocardial infarction is secondary to increase in regional left ventricular volumes
Conference name European Society of Cardiology Congress
Conference location Stockholm , Sweden
Conference dates 3rd - 7th September, 2005
Proceedings title European Heart Journal: Abstracts selected for presentation at the European Society of Cardiology Congress   Check publisher's open access policy
Journal name European Heart Journal   Check publisher's open access policy
Place of Publication London ; New York
Publisher Oxford University Press
Publication Year 2005
Sub-type Published abstract
ISSN 1522-9645
0195-668X
Editor Frans Van de Werf
Volume 26
Issue Supplement 1
Start page 139
End page 139
Total pages 1
Language eng
Abstract/Summary We sought to determine the relative impact of myocardial scar and viability on post-infarct left ventricular (LV) remodeling in medically-treated patients with LV dysfunction. Forty patients with chronic ischemic heart disease (age 64±9, EF 40±11%) underwent rest-redistribution Tl201 SPECT (scar = <60% maximum Tl uptake), dobutamine echo (DbE; scar = no contractile reserve), and gadolinium late-enhanced cardiovascular magnetic resonance imaging (CMR; scar = >50% transmural extent), A global index of scarring for each patient (CMR scar score) was calculated as the sum of transmural extent scores in all segts. LV end diastolic volumes (LVEDV) and LV end systolic volumes (LVESV) were measured by real-time threedimensional echo at baseline and median of 12 months follow-up. There was a significant positive correlation between change in LVEDV with number of scar segts by all three imaging techniques (LVEDV: SPECT scar, r = 0.62, p < 0.001; DbE scar, r = 0.57, p < 0.001; CMR scar, r = 0.52, p < 0.001) but change in LV volumes did not the correlate with number of viable segments. ROC curve analysis showed that remodeling (LVEDV> 15%) was predicted bySPECTscars(AUC= 0.79),DbEscars(AUC= 0.76),CMR scars (AUC= 0.70), and CMR scar score (AUC 0.72). There were no significant differences between any of the ROC curves (Z score <0.74). Number of SPECT scars (p = 0.002), DbE scars (p = 0.01), CMR scars (p = 0.004), and CMR scar score (p = 0.03) were independent predictors of LVEDV. The extent of scar tissue can predict global LV remodeling irrespective of cardiac imaging technique but myocardial viability may not be protective against LV remodeling in medically-treated patients.
Formatted Abstract/Summary




Subjects EX
110201 Cardiology (incl. Cardiovascular Diseases)
110299 Cardiovascular Medicine and Haematology not elsewhere classified
Q-Index Code EX

 
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Created: Fri, 24 Aug 2007, 06:28:01 EST