Use Of Complementary Medicines For Osteoarthritis - a Prospective Study

Zochling, J., March, L. M., Lapsley, H., Cross, M., Tribe, K. and Brooks, P. (2004) Use Of Complementary Medicines For Osteoarthritis - a Prospective Study. Annals of the Rheumatic Diseases, 63 5: 549-554. doi:10.1136/ard.2003.010637

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
use_of_complemen.pdf use_of_complemen.pdf application/pdf 196.86KB 924

Author Zochling, J.
March, L. M.
Lapsley, H.
Cross, M.
Tribe, K.
Brooks, P.
Title Use Of Complementary Medicines For Osteoarthritis - a Prospective Study
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
1468-2060
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1136/ard.2003.010637
Open Access Status File (Author Post-print)
Volume 63
Issue 5
Start page 549
End page 554
Total pages 6
Editor ven de Putte, L.
O'Flaherty, J.
Place of publication London, U.K.
Publisher BMJ Publishing Group
Collection year 2004
Language eng
Subject 321028 Rheumatology and Arthritis
C1
730306 Evaluation of health outcomes
Abstract Background: Patients with osteoarthritis commonly use complementary and alternative medicines (CAM),either as an adjunct to or in place of conventional analgesics. Objectives: To undertake a prospective investigation of the prevalence of CAM use for osteoarthritis and the direct costs incurred. Methods: The subjects were 341 patients with osteoarthritis of the knee or hip drawn from central and northern Sydney, Australia, and comprising 83 community based patients and 258 awaiting joint replacement. Information on CAM use was obtained from prospective three monthly diaries. Variables of interest included health related quality of life scores. Prospective out of pocket costs were recorded over a 12 month follow up period. Results: The prevalence of CAM use was 40%, which falls within the range of previous studies. Average annual expenditure on CAM was A$32.25 (range 0 to 603.30). CAM users were more likely to be female (odds ratio (OR) 1.8 (95% confidence interval, 1.1 to 3.0)), reported a higher level of bodily pain (OR 0.97 (0.95 to 0.99)), and were less likely to purchase conventional analgesics (OR 3.3 (1.6 to 7.0)), either prescribed or over the counter. Vitamin supplementation was the most common CAM reported, followed by celery extract, fish oils, and garlic extracts. Conclusions: There are no good quality clinical trials to support the use of most preparations purchased by patients with osteoarthritis. There is a need for patient education on the risks and benefits of complementary medicine in osteoarthritis.
Keyword complementary therapies
Knee Replacement Surgery
alternative medicine
Glucosamine Sulfate
Chondroitin Sulfate
Controlled Trials
Herbal Medicines
Medication Use
United-states
Population
Arthritis
osteoarthritis
References 1 Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al .Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998;41:778-99. 2 Centers for Disease Control and Prevention. Estimated number of US population with physician-diagnosed osteoarthritis, 1990. Atlanta: Centers for Disease Control and Prevention, 1995. 3 Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly: the Framingham osteoarthritis study. Arthritis Rheum 1987;30:914-18. 4 Van Saase JLCM, van Romunde LKJ, Cats A, Vandenbroucke JP, Valkenburg HA. Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis 1989;48:271-80. 5 Elders MJ. The increasing impact of arthritis on public health. J Rheumatol 2000;60(suppl):6-8. 6 Mathers C, Penn R. Health system costs of injury, poisoning and musculoskeletal disorders in Australia 1993-4. Canberra: Australian Institute of Health and Welfare, 1999. 7 Ausiello JC, Stafford RS. Trends in medication use for osteoarthritis treatment. J Rheumatol 2002;29:999-1005. 8 Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 2002;287:337-44. 9 March LM, Schwarz JM, Carfrae BH, Bagge E. Clinical validation of selfreported osteoarthritis. Osteoarthritis Cartilage 1998;6:87-93. 10 Bellamy N. WOMAC users guide. London, Ontario: University of Western Ontario, 1995. 11 Ware JE, Brook RH, Davies-Avery A, Williams KN, Stewart AL, Rogers WH, et al. Conceptualization and measurement of health for adults in the health insurance study. Santa Monica: Rand Corporation, 1980. 12 March LM, Cross MJ, Lapsley H, Brnabic AJ, Tribe KL, Bachmeier CJ, et al. Outcomes after hip or knee replacement surgery for osteoarthritis. A prospective cohort study comparing patients' quality of life before and after surgery with age-related population norms. Med J Aust 1999;171:235-8. 13 Bachmeier CJ, March LM, Cross MJ, Lapsley HM, Tribe KL, Courtenay BG, et al. A comparison of outcomes in osteoarthritis patients undergoing total hip and knee replacement surgery. Osteoarthritis Cartilage 2001;9:137-46. 14 March L, Cross M, Tribe K, Lapsley H, Courtenay B, Brooks P. Cost of joint replacement surgery for osteoarthritis: the patients' perspective. J Rheumatol 2002;29:1006-14. 15 Lapsley HM, March LM, Tribe KL, Cross MJ, Brooks PM. Living with osteoarthritis: patient expenditures, health status, and social impact. Arthritis Rheum 2001;45:301-6. 16 MacLennan AH, Wilson DH, Taylor AW. Prevalence and cost of alternative medicine in Australia. Lancet 1996;347:569-73. 17 Ramsey SD, Spencer AC, Topolski TD, Belza B, Patrick DL. Use of alternative therapies by older adults with osteoarthritis. Arthr Care Res 2001;45:222-7. 18 Boisset M, Fitzcharles M-A. Alternative medicine use by rheumatology patients in a universal health care setting. J Rheumatol 1993;21:148-52. 19 Pioro-Boisset M, Esdaile JM, Fitzcharles M-A. Alternative medicine use in fibromyalgia syndrome. Arthritis Care Res 1996;9:13-17. 20 Rao JK, Mihaliak K, Kroenke K, Bradley J, Tierney WM, Weinberger M. Use of complementary therapies for arthritis among patients of rheumatologists. Ann Intern Med 1999;131:409-16. 21 Linde K, Jonas WB, Melchart D, Willich S. The methodological quality of randomized controlled trials of homeopathy, herbal medicines and acupuncture. Int J Epidemiol 2001;30:526-31. 22 Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges LV, et al. Are the clinical effects of homoeopathy placebo effects? a meta-analysis of placebocontrolled trials. Lancet 1997;350:834-43. 23 McAlindon TE, Jacques P, Zhang X, Hannan MT, Aliabadi P, Weissman B, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum 1996;39:648-56. 24 Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 2001;44:2531-8. 25 Bliddal H, Rosetzsky A, Schlichting P, Weidner MS, Andersen LA, Ibfelt H-H, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and Ibuprofen in osteoarthritis. Osteoarthritis Cartilage 2000;8:9-12. 26 Zhang W, Li Wan Po A. The effectiveness of topically applied capsaicin. A meta-analysis. Eur J Clin Pharmacol 1994;46:517-22. 27 Chantre P, Cappelaere A, Leblan D, Guedon D, Vandermander J, Fournie B. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83. 28 Lecomte A, Costa JP. Harpagophytum. dans l'arthrose: etudes en double insu contre placebo. 3702 Le Magazine 1992;15:27-30. 29 Guyader M. Les plantes antirhumatismales. Etude historique et pharmacologique, et etude clinique du nebulisat d'Harpagophytum procumbens DC chez 50 patients arthrosiques suivis en service hospitalier. Paris: Universite Pierre et Marie Curie, 1984. 30 Towheed TE, Anastassiades TP, Shea B, Houpt J, Welch V, Hochberg MC. Glucosamine therapy for treating osteoarthritis (Cochrane review). Cochrane Database Syst Rev 2001;3. 31 McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000;283:1469-75. 32 Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, et al. Longterm effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001;357:251-6. 33 Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23. 34 Bruyere O, Honore A, Ethgen O, Rovati LC, Giacovelli G, Henrontin YE, et al. Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis Cartilage 2003;11:1-5. 35 Leeb BF, Schweitzer H, Montag K, Smolen JS. A meta-analysis of chondroitin sulfate in treatment of osteoarthritis. J Rheumatol 2000;27:205-11. 36 Michel B, Vignon E, de Vathaire F, Frey D, Hauselmann HJ, Stucki G, et al. Oral chondroitin sulphate in knee OA patients: radiographic outcomes of a 2-year prospective study [abstract]. Osteoarthritis Cartilage 2001;9(suppl B):S68. 37 Uebelhart D, Eugene J-M, Thonar A, Delmas PD. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(suppl A):S39-46. 38 Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA [abstract]. Osteoarthritis Cartilage 1998;6(suppl A):S37-8. 39 Schmid B, Tschirdewahn B, Kotter I. Analgesic effects of willow bark extract in osteoarthritis: results of a clinical double-blind trial. FACT: Focus Alternative Complementary Ther 1997;3:86. 40 Little CV, Parsons T. Herbal therapy for treating osteoarthritis. Cochrane Database Syst Rev 2001;1:CD002947. 41 Randall C, Randall H, Dobbs F, Hutton C, Sanders H. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. 42 Long L, Soeken K, Ernst E. Herbal medicines for the treatment of osteoarthritis: a systematic review. Rheumatology (Oxford) 2001;40:779-93. 43 Jacobs JWG, Kraaimaat FW, Bijlsma JWJ. Why do patients with rheumatoid arthritis use alternative treatments. Clin Rheumatol 2001;20:192-6. 44 Buchbinder R, Gingold M, Hall S, Cohen M. Non-prescription complementary treatments used by rheumatoid arthritis patients attending a community-based rheumatology practice. Intern Med J 2002;32:208-14. 45 Menniti-Ippolito F, Gargiulo L, Bologna E, Forcella E, Raschetti R. Use of unconventional medicine in Italy: a nation-wide survey. Eur J Clin Pharmacol 2002;58:61-4. 46 Cherniack EP, Senzel RS, Pan CX. Correlates of use of alternative medicine by the elderly in an urban population. J Altern Complement Med 2001;7:277-80. 47 Kaboli PJ, Doebbeling BN, Saag KG, Rosenthal GE. Use of complementary and alternative medicine by older patients with arthritis: a population-based study. Arthritis Rheum 2001;45:398-403. 48 Bernstein JH, Shuval JT. Nonconventional medicine in Israel: consultation patterns of the Israeli population and attitudes of primary care physicians. Soc Sci Med 1997;44:1341-8.
Q-Index Code C1
Additional Notes Reproduced from J Zochling, L M March, H Lapsley, M Cross, K Tribe, P Brooks, (2004) Use Of Complementary Medicines For Osteoarthritis - a Prospective Study, Annals of the Rheumatic Diseases, 63, 549-554. Copyright 2004 BMJ Publishing.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 33 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 46 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 10 Dec 2004, 10:00:00 EST by Di Thornthwaite on behalf of School of Medicine