Relationship of hypertension and cardiovascular disease (CVD) at autopsy to glomerular number

Hoy, W. E., Bertram, J.F., Hughson, M. D. and Douglas-Denton, R. (2003). Relationship of hypertension and cardiovascular disease (CVD) at autopsy to glomerular number. In: Nephrology. 39th Annual Scientific Meeting of ANZSN, Perth, Western Australia, (A87-A87). 31 Aug - 3 Sep, 2003.


Author Hoy, W. E.
Bertram, J.F.
Hughson, M. D.
Douglas-Denton, R.
Title of paper Relationship of hypertension and cardiovascular disease (CVD) at autopsy to glomerular number
Conference name 39th Annual Scientific Meeting of ANZSN
Conference location Perth, Western Australia
Conference dates 31 Aug - 3 Sep, 2003
Proceedings title Nephrology   Check publisher's open access policy
Place of Publication Carlton, Australia
Publisher Blackwell Publishing Asia
Publication Year 2003
ISSN 1320-5358
Volume 8
Issue Suppl
Start page A87
End page A87
Total pages 1
Language eng
Formatted Abstract/Summary
Objective: To evaluate whether low nephron number predisposes to hypertension,as proposed by Brenner and reported by Keller et al. NEJM 2003, and toCVD.
Methods: 
Kidneys were studied at coronial autopsy in 37 adults (18 + year) fromthe Northern Territory. Sixteen were Aboriginal and 21 were nonAboriginal,with 27 males and 10 females, ages 19–85 year, mean 43.5 (17.1) year. The rightkidney was perfusion-fixed and sampled for stereology, and total glomerularnumber (Nglom) and mean renal corpuscle volume were measured by thedisector/fractionator method. The clinical history was recorded, as well as organweights and other autopsy findings.
Results: 
Fifteen were smokers, 15 were drinkers, nine had hypertension and fourhad type 2 diabetes. Coronary artery disease (CAD) was present in 18, and someform of CVD in 20. Nglom did not vary by smoking, drinking, or diabetes. Thosewith hypertension tended towards fewer glomeruli (708 652 vs. 848,295, p =0.176) and lower total renal corpuscle mass (4.9 cm3 vs. 5.9 cm3, p = 0.21), butthe differences were not significant. (Neither did they have increased heartweight, p = 0.89). There were no differences in Nglom by CAD (773 566 vs.809,076, p = 0.70), or by CVD (768 887 vs. 793,767, p = 0.76). Nglom tended tobe lower in the four people with macroscopic renal abnormalities (584 711 vs.824,036, p = 0.06).
Conclusion: 
Despite a trend, we could not confirm a significant relationshipbetween nephron number and hypertension. Factors driving this discrepancymight include an insensitive ascertainment of history, more serious hypertensionin Keller’s group, and the possibility that nephron loss in that group wassecondary to hypertension, rather than the initiating factor.
Subjects EX
321207 Indigenous Health
730206 Aboriginal and Torres Strait Islander health
1103 Clinical Sciences
Keyword Hypertension
Cardiovascular disease (CVD)
Nephron number
Autopsy
Glomerular number
Q-Index Code EX

 
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Created: Thu, 23 Aug 2007, 19:10:18 EST