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Ruitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. In: Journal of Neurotrauma. 11th Symposium of the International-Neurotrauma-Society, Budapest Hungary, (A26-A26). Mar 19-23, 2014. 75   0
Woodruff, T. M., Proctor, L. M., Shiels, I. A. and Taylor, S. M. (2004). A cyclic peptide, C5a receptor antagonist analogue confers increased potency in a model of inflammatory bowel disease in rats. In: Molecular immunology: Abstracts of the 20th International Complement Workshop. 20th International Complement Workshop, Honolulu, Hawaii, (326-326). 13-18 June, 2004. doi:10.1016/j.molimm.2004.03.002 283   1 0
Woodruff, T. M., Shiels, I. A., Fairlie, D. and Taylor, S. M. (2001). A new C5a receptor antagonist inhibits monoarticular arthritis in the rat. In: Proceedings of the Complement Associated Diseases, Animal Models and Therapeutics Workshop. Complement Assoc. Diseases, Animal Models & Ther. Workshop, Santorini, Greece, (37-37). 10-14 October, 2001. 80  
Strachan, A. J., Woodruff, T.M., Haaima, G., Fairlie, D. P. and Taylor, S. M. (2000) A new small molecule C5a receptor antagonist inhibits the reverse-passive arthus reaction and endotoxic shock in rats. Journal of Immunology, 164 4: 6560-6565. 119   81
Benson, Melissa J, Thomas, Nicola K, Talwar, Sahil, Hodson, Mark P, Lynch, Joseph W, Woodruff, Trent M and Borges, Karin (2015) A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models. Neurobiology of Disease, 76 87-97. doi:10.1016/j.nbd.2015.02.004 47   Cited 0 times in Scopus0 0
Jain, Umang, Woodruff, Trent and Stadnyk, Andrew (2012). Antagonizing C5aR reduces T Cell- IL-10-dependent colitis in pre-clinical models. In: 2012 Advances in Inflammatory Bowel Diseases Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, Fl, United States, (S110-S110). 13-15 December 2012. doi:10.1002/ibd.23058 51   0 0
Woodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 9: 2476-2485. doi:10.1002/art.10449 103   75 Cited 74 times in Scopus74 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005) A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 5: 883-892. doi:10.1016/j.intimp.2005.01.003 91   21 Cited 26 times in Scopus26 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003) A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 10: 5514-5520. 97   75 Cited 75 times in Scopus75
Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013) A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 10: 1557-1568. doi:10.1111/pme.12157 75   12 Cited 16 times in Scopus16 4
Woodruff, Trent, Denny, Kerina, Crane, James, Atkin, Julie, Taylor, Steve and Noakes, Peter (2008). Blockade of C5a receptors reduces astroglial inflammation in a rat SOD1G93A model of amyotrophic lateral sclerosis. In: Robert Rieben, Molecular Immunology.. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4163-4182). 28 September-02 October 2008. doi:10.1016/j.molimm.2008.08.202 166   0 0
Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014) Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 12: 3278-3284. doi:10.1002/stem.1801 34   0 Cited 1 times in Scopus1 1
Woodruff, Trent M. (2014). C3a and C5a homeostasis in health and disease. In: Molecular Immunology. 25th International Complement Workshop, Rio de Janeiro Brazil, (247-248). Sep 14-18, 2014. 12   0
Denny, Kerina J., Coulthard, Liam G., Jeanes, Angela, Lisgo, Steven, Simmons, David G., Callaway, Leonie K., Wlodarczyk, Bogdan, Finnell, Richard H., Woodruff, Trent M. and Taylor, Stephen M. (2013) C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. Journal of Immunology, 190 7: 3493-3499. doi:10.4049/jimmunol.1203072 54   3 Cited 4 times in Scopus4 0
Costantini, K. J., Coulthard, L. G. J., Lor, Mary, Woodruff, T. M., Callaway, L. K., Finnell, R. H. and Taylor, S. M. (2010). C5aR protects against folate-deficiency induced neural tube defects in mice. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2254-2254). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.169 77   1 0
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M. and Woodruff, Trent M. (2013) C5L2: a controversial receptor of complement anaphylatoxin, C5a. FASEB Journal, 27 3: 855-864. doi:10.1096/fj.12-220509 67   28 Cited 28 times in Scopus28 1
Beck, K. D., Nguyen, H. X., Woodruff, T. M. and Anderson, A. J. (2008). Chronic complement-mediated inflammation promotes recovery after spinal cord injury. In: Abstracts of the 39th Annual Meeting of the American Society for Neurochemistry. American Society for Neurochemistry 39th Annual Meeting, San Antonio, United States, (105-105). 1-5 March 2008. doi:10.1111/j.1471-4159.2008.05160.x 95   1 0
Higginbottom, Adrian, Cain, Stuart A., Woodruff, Trent M., Proctor, Lavinia M., Madala, Praveen K., Tyndall, Joel D. A., Taylor, Stephen M., Fairlie, David P. and Monk, Peter N. (2005) Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280 18: 17831-17840. doi:10.1074/jbc.M410797200 111   24 Cited 24 times in Scopus24 0
Coulthard, Liam G., Costello, Jaclyn, Robinson, Brent, Shiels, Ian A., Taylor, Stephen M. and Woodruff, Ttrent M. (2011) Comparative efficacy of a secretory phospholipase A(2) inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis. Arthritis Research & Therapy, 13 2: R42-1-R42-10. doi:10.1186/ar3278 79   8 Cited 9 times in Scopus9 0
Brennan, Faith H., Anderson, Aileen J., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012) Complement activation in the injured central nervous system: Another dual-edged sword?. Journal of Neuroinflammation, 9 1: . doi:10.1186/1742-2094-9-137 65   28 Cited 27 times in Scopus27 2
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011) Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 7: 2447-2455. doi:10.1096/fj.10-174284 68   28 Cited 29 times in Scopus29 0
Lappas, Martha, Woodruff, Trent M., Taylor, Stephen M. and Permezel, Michael (2012) Complement C5a regulates prolabor mediators in human placenta. Biology of Reproduction, 86 6: 190.1-190.9. doi:10.1095/biolreprod.111.098475 32   4 Cited 6 times in Scopus6 1
Manthey, Helga D., Woodruff, Trent M., Taylor, Stephen M. and Monk, Peter N. (2009) Complement component 5a (C5a). International Journal of Biochemistry and Cell Biology, 41 11: 2114-2117. doi:10.1016/j.biocel.2009.04.005 96   50 Cited 52 times in Scopus52 3
Coulthard, L. G. J., Costantini, K. J., Lor, Mary, Simmons, D., Taylor, S. M. and Woodruff, T. M. (2010). Complement expression in mice throughout neural tube closure. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2251-2251). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.163 57   2 0
Woodruff, T.M., Proctor, L.M., Strachan, A.J. and Taylor, S.M. (2006) Complement factor 5a as a therapeutic target. Drugs of The Future, 31 4: 325-334. doi:10.1358/dof.2006.031.04.980656 87   7 Cited 7 times in Scopus7 0
de Vries, Margreet R., Wezel, Anouk, Schepers, Abbey, van Santbrink, Peter J., Woodruff, Trent M., Niessen, Hans W. M., Hamming, Jaap F., Kuiper, Johan, Bot, Ilze and Quax, Paul H. A. (2013) Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. Cardiovascular Research, 97 2: 311-320. doi:10.1093/cvr/cvs312 34   10 Cited 10 times in Scopus10 0
Proctor, Lavinia M., Moore, Tyson A., Monk, Peter N., Sanderson, Sam D., Taylor, Stephen M. and Woodruff, Trent M. (2009) Complement factors C3a and C5a have distinct hemodynamic effects in the rat. International Immunopharmacology, 9 6: 800-806. doi:10.1016/j.intimp.2009.03.002 88   9 Cited 10 times in Scopus10 0
Proctor, Lavinia M., Strachan, Anna J., Woodruff, Trent M., Mahadevan, Indumathy B., Williams, H. Ming, Shiels, Ian A. and Taylor, Stephen M. (2006) Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. International Immunopharmacology, 6 8: 1224-1232. doi:10.1016/j.intimp.2006.03.002 343   19 Cited 23 times in Scopus23 0
Denny, Kerina J., Woodruff, Trent M., Taylor, Stephen M. and Callaway, Leonie K. (2013) Complement in pregnancy: a delicate balance. American Journal of Reproductive Immunology, 69 1: 3-11. doi:10.1111/aji.12000 57   10 Cited 12 times in Scopus12 0
Arumugam, Thiruma V., Magnus, Tim, Woodruff, Trent M., Proctor, Lavinia M., Shiels, Ian A., Taylor, Stephen M., A. H. Wu and J. Delanghe (2006) Complement mediators in ischemia-reperfusion injury. Clinica Chimica Acta, 374 1-2: 33-45. doi:10.1016/j.cca.2006.06.010 68   61 Cited 64 times in Scopus64 0
Gu H., Mickler E.A., Cummings O.W., Sandusky G.E., Weber D.J., Gracon A., Woodruff T., Wilkes D.S. and Vittal R. (2014) Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis. FASEB Journal, 28 10: 4223-4234. doi:10.1096/fj.13-247650 14   0 Cited 0 times in Scopus0 1
Brennan, Faith H., Blomster, Linda V., Costantini, Alexander M., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia. In: Proceedings of the 11th International Congress of Neuroimmunology (ISNI). 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, (89-90). 4-8 November 2012. 74   0
Peng, Qi, Li, Ke, Wang, Naiyin, Li, Qijun, Asgari, Elham, Lu, Bao, Woodruff, Trent M., Sacks, Steven H. and Zhou, Wuding (2009) Dendritic cell function in allostimulation is modulated by C5aR signaling. Journal of Immunology, 183 10: 6058-6068. doi:10.4049/jimmunol.0804186 55   55 Cited 55 times in Scopus55 0
Bellows-Peterson, Meghan L., Fung, Ho Ki, Floudas, Christodoulos A., Kieslich, Chris A., Zhang, Li, Morikis, Dimitrios, Wareham, Kathryn J., Monk, Peter N., Hawksworth, Owen A. and Woodruff, Trent M. (2012) De novo peptide design with C3a receptor agonist and antagonist activities: Theoretical predictions and experimental validation. Journal of Medicinal Chemistry, 55 9: 4159-4168. doi:10.1021/jm201609k 60   21 Cited 21 times in Scopus21 0
Monkl, Peter N., Bellows-Peterson, Meghan L., Smadbeck, James, Floudas, Christodoulos A., Kieslich, Christopher A., Morikis, Dimitrios and Woodruff, Trent M. (2012). De novo protein design of agonists and antagonists of C5a receptors. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1162-1163). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.097 46   1 0
Halai, Reena, Bellows-Peterson, Meghan L., Branchett, Will, Smadbeck, James, Kieslich, Chris A., Croker, Daniel E., Cooper, Matthew A., Morikis, Dimitrios, Woodruff, Trent M., Floudas, Christodoulos A. and Monk, Peter N. (2014) Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. European Journal of Pharmacology, 745 176-181. doi:10.1016/j.ejphar.2014.10.041 16   1 Cited 1 times in Scopus1 1
Croker, Daniel E., Halai, Reena, Kaeslin, Geraldine, Morikis, Dimitrios, Woodruff, Trent, Floudas, Christodoulos A., Monk, Peter N. and Cooper, Matthew A. (2014). Discovery of novel selective C5a2 ligands that can modulate IL-6 releAse from macrophages. In: 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, (35-35). Oct 26-29, 2014. doi:10.1016/j.cyto.2014.07.039 28   0 0
Proctor, L.M., Woodruff, T.M., Pazckowski, N.P., Monk, P.N. and Taylor, S.M. (2004). Dual C3a/C5a receptor agonism by a C5a C-terminal analogue decapeptide. In: Molecular Immunology: Abstracts of the 20th International Complement Workshop. 20th International Complement Workshop, Honolulu, Hawaii, (297-297). 13-18 June, 2004. doi:10.1016/j.molimm.2004.03.002 99   0 0
Lee, John D., Kamaruzaman, Nur A., Fung, Jenny N. T., Taylor, Stephen M., Turner, Bradley J., Atkin, Julie D., Woodruff, Trent M. and Noakes, Peter G. (2013) Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 10 . doi:10.1186/1742-2094-10-119 57   7 Cited 6 times in Scopus6 3
Woodruff, T. M., Lee, J. D., Taylor, S. M. and Noakes, P. G. (2010). Dysregulation of the complement system in neurodegenerative disease. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2270-2270). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.215 69   0 0
Denny, Kerina J., Coulthard, Liam G., Finnell, Richard H., Callaway, Leonie K., Taylor, Stephen M. and Woodruff, Trent M. (2013) Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. Journal of Reproductive Immunology, 97 2: 211-216. doi:10.1016/j.jri.2012.11.006 41   6 Cited 7 times in Scopus7 0
Mantovani, S., Gordon, R., Macmaw, J. K., Plfluger, C. M., Henderson, R. D., Noakes, P. G., McCombe, P. A. and Woodruff, T. M. (2014) Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood. Journal of Neuroimmunology, 276 1-2: 213-218. doi:10.1016/j.jneuroim.2014.09.005 102   1 Cited 0 times in Scopus0 1
Coulthard, Mark G., Morgan, Michael, Woodruff, Trent M., Arumugam, Thiruma V., Taylor, Stephen M., Carpenter, Todd C., Martin Lackmann, and Boyd, Andrew W. (2012) Eph/Ephrin signaling in injury and inflammation. American Journal of Pathology, 181 5: 1493-1503. doi:10.1016/j.ajpath.2012.06.043 80   16 Cited 17 times in Scopus17 0
Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014) Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126 13-27. doi:10.1016/j.pbb.2014.09.003 42   0 Cited 0 times in Scopus0 0
Thundyil, John, Tang, Sung-Chun, Okun, Eitan, Shah, Kausik, Karamyan, Vardan T., Li , Yu-I, Woodruff, Trent M., Taylor, Stephen M., Jo, Dong-Gyu, Mattson, Mark P and Arumugam, Thiruma V. (2010) Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Experimental and Translational Stroke Medicine, 2 1: 15-1-15-8. doi:10.1186/2040-7378-2-15 58   Cited 17 times in Scopus17 0
Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2012). Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1169-1169). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.116 47   0 0
Pavlovski, Dale, Thundyil, John, Monk, Peter N., Wetsel, Rick A., Taylor, Stephen M. and Woodruff, Trent M. (2012) Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. The FASEB Journal, 26 9: 3680-3690. doi:10.1096/fj.11-202382 86   17 Cited 21 times in Scopus21 0
Hezmee, Mnm, Kyaw-Tanner, M, Lee, JYP, Shiels, IA, Rolfe, B, Woodruff, T and Mills, PC (2011) Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors. Veterinary Immunology and Immunopathology, 139 1: 50-56. doi:10.1016/j.vetimm.2010.08.005 135   2 Cited 2 times in Scopus2 0
Dekker Nitert, Marloes, Barrett, Helen L., Kubala, Marta H., Scholz Romero, Katherin, Denny, Kerina J., Woodruff, Trent M., David McIntyre, H. David and Callaway, Leonie K. (2014) Increased placental expression of fibroblast growth factor 21 in gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 99 4: E591.1-E591.8. doi:10.1210/jc.2013-2581 37   Cited 1 times in Scopus1 2
Woodruff, T. M., Pollitt, S., Proctor, L. M., Stocks, S. Z., Manthey, H. D., Williams, H. M., Mahadevan, I. B., Shiels, I. A. and Taylor, S. M. (2005) Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease. Journal of Pharmacology And Experimental Therapeutics, 314 2: 811-817. doi:10.1124/jpet.105.086835 71   33 Cited 34 times in Scopus34 0

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