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Pless, Stephan A., Hanek, Ariele P., Price, Kerry L., Lynch, Joseph W., Lester, Henry A., Dougherty, Dennis A. and Lummis, Sarah C. R. (2011) A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Molecular Pharmacology, 79 4: 742-748. doi:10.1124/mol.110.069583 111 1 16 Cited 17 times in Scopus17 0
Pless, Stephan A., Millen, Kat S., Hanek, Ariele P., Lynch, Joseph W., Lester, Henry A., Lummis, Sarah C. R. and Dougherty, Dennis A. (2008) A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue. Journal of Neuroscience, 28 43: 10937-10942. doi:10.1523/JNEUROSCI.2540-08.2008 248   42 Cited 45 times in Scopus45 0
Seebungkert, B and Lynch, JW (2001) A common inhibitory binding site for zinc and odorants at the voltage-gated K+ channel of rat olfactory receptor neurons. European Journal of Neuroscience, 14 2: 353-362. doi:10.1046/j.0953-816x.2001.01646.x 49   8 0
Wang, Qian and Lynch, Joseph W. (2012) A comparison of glycine-and ivermectin-mediated conformational changes in the glycine receptor ligand-binding domain. International Journal of Biochemistry and Cell Biology, 44 2: 335-340. doi:10.1016/j.biocel.2011.11.005 83 14 4 Cited 5 times in Scopus5 0
Lynch, JW and Barry, PH (1989) Action-Potentials Initiated by Single Channels Opening in a Small Neuron (Rat Olfactory Receptor). Biophysical Journal, 55 4: 755-768. 22   99
Wang, Qian and Lynch, Joseph W. (2011) Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor. Journal of Biological Chemistry, 286 44: 38814-38824. doi:10.1074/jbc.M111.273631 83 1 6 Cited 6 times in Scopus6 0
Lynagh, Timothy and Lynch, Joseph W. (2010) A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors. International Journal for Parasitology, 40 13: 1477-1481. doi:10.1016/j.ijpara.2010.07.010 48   25 Cited 26 times in Scopus26 0
Ryan, SG, Buckwalter, MS, Lynch, JW, Handford, CA, Segura, L, Shiang, R, Wasmuth, JJ, Camper, SA, Schofield, P and Oconnell, P (1994) A Missense Mutation in the Gene Encoding the Alpha(1) Subunit of the Inhibitory Glycine Receptor in the Spasmodic Mouse. Nature Genetics, 7 2: 131-135. doi:10.1038/ng0694-131 17   138 Cited 132 times in Scopus132 0
Bode, Anna and Lynch, Joseph W. (2013) Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor activation. Journal of Biological Chemistry, 288 47: 33760-33771. doi:10.1074/jbc.M113.513804 66 3 2 Cited 3 times in Scopus3 0
Rajendra, S, Lynch, JW and Barry, PH (1992) An Analysis of Na+ Currents in Rat Olfactory Receptor Neurons. Pflugers Archiv-European Journal of Physiology, 420 3-4: 342-346. doi:10.1007/BF00374468 15   44 Cited 37 times in Scopus37 0
Lynagh, Timothy and Lynch, Joseph W. (2010) An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populations. Journal of Biological Chemistry, 285 20: 14890-14897. doi:10.1074/jbc.M110.107789 46   21 Cited 22 times in Scopus22 0
Keramidas, Angelo and Lynch, Joseph W. (2012) An outline of desensitization in pentameric ligand-gated ion channel receptors. Cellular and Molecular Life Sciences, 70 7: 1241-1253. doi:10.1007/s00018-012-1133-z 46 1 5 Cited 5 times in Scopus5 0
Hawthorne, Rebecca L. and Lynch, Joseph W. (2005) A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop.. Journal of Biological Chemistry, 280 43: 35836-35843. doi:10.1074/jbc.M506645200 77   27 Cited 27 times in Scopus27 0
Nevin, S., Haddrill, J. L. and Lynch, J. W. (2001). A pore-lining glutamic acid in the olfactory cyclic nucleotide-gated channel controls external spermine block. In: Proceedings of the Australian Neuroscience Society. 21st Annual Meeting of the Australian Neuroscience Society, Brisbane, Australia, (93-93). 28-31 January, 2001. 135  
Nevin, Simon T., Haddrill, Justine L. and Lynch, Joseph W. (2000) A pore-lining glutamic acid in the rat olfactory cyclic nucleotide-gated channel controls external spermine block. Neuroscience Letters, 296 2-3: 163-167. doi:10.1016/S0304-3940(00)01650-5 50   8 Cited 8 times in Scopus8 0
Yang, Zhe, Cromer, Brett A., Harvey, Robert J., Parker, Michael W. and Lynch, Joseph W. (2007) A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. Journal of Neurochemistry, 103 2: 580-589. doi:10.1111/j.1471-4159.2007.04850.x 71   33 Cited 34 times in Scopus34 0
Shan, Q., Haddrill, J. L. and Lynch, J. W. (2001) A single beta subunit M2 domain residue controls the picrotoxin sensitivity of alpha beta heteromeric glycine receptor chloride channels. Journal of Neurochemistry, 76 4: 1109-1120. doi:10.1046/j.1471-4159.2001.00124.x 54   51 Cited 52 times in Scopus52 0
Shan, Q., Nevin, S. T., Haddrill, J. L. and Lynch, J. W. (2003) Asymmetric contribution of α and β subunits to the activation of αβ heteromeric glycine receptors. Journal of Neurochemistry, 86 2: 498-507. doi:10.1046/j.1471-4159.2003.01872.x 85   23 Cited 24 times in Scopus24 0
Lynch, JW, Barry, PH and Quartararo, N (1988) A Temperature and Solution Control-System for the Measurement of Single Channel Currents in Excised Membrane Patches. Pflugers Archiv-European Journal of Physiology, 412 3: 322-327. doi:10.1007/BF00582515 14   7 0
Balansa, Walter, Islam, Robiul, Gilbert, Daniel F., Fontaine, Frank, Xiao, Xue, Zhang, Hua, Piggott, Andrew M., Lynch, Joseph W. and Capon, Robert J. (2013) Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator. Bioorganic and Medicinal Chemistry, 21 14: 4420-4425. doi:10.1016/j.bmc.2013.04.061 64 1 8 Cited 7 times in Scopus7 0
Kruger, Wade, Gilbert, Daniel, Hawthorne, Rebecca, Hryciw, Deanne H., Frings, Stephan, Poronnik, Philip and Lynch, Joseph W. (2005) A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABA(A) receptor chloride channels. Neuroscience Letters, 380 3: 340-345. doi:10.1016/j.neulet.2005.01.065 122   31 Cited 31 times in Scopus31 0
Shan, Qiang, Han, Lu and Lynch, Joseph W. (2011) Beta subunit M2-M3 loop conformational changes are uncoupled from alpha1 beta glycine receptor channel gating: Implications for human hereditary hyperekplexia. PLoS One, 6 11: e28105.1-e28105.11. doi:10.1371/journal.pone.0028105 56   7 Cited 6 times in Scopus6 0
Lynch, J. W., Han, N. and Schofield, P. R. (1999). Building new function into glycine receptors: A structural model for the activation of the glycine-gated chloride channel. In: W. Anderson, Proceedings of the Australian Neuroscience Society, 1998. Australian Neuroscience Society, 1998, Hobart, Tasmania, Australia, (932-934). 28th January - 1st February, 1999. doi:10.1046/j.1440-1681.1999.03150.x 37   3 Cited 3 times in Scopus3 0
Balasubramanian, S, Lynch, JW and Barry, PH (1996) Calcium-dependent modulation of the agonist affinity of the mammalian olfactory cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor. Journal of Membrane Biology, 152 1: 13-23. doi:10.1007/s002329900081 11   47 Cited 47 times in Scopus47 0
Han, N., Haddrill, J. L. and Lynch, J. W. (2001). Characterisation of a putative antagonist binding domain in the glycine receptor chloride channel. In: P. Pilowsky, Proceedings of the Australian Neuroscience Society. 21st Annual Meeting of the Australian Neuroscience Society, Brisbane, (75-75). 28-31 January 2001. 59  
Han, Nian-Lin R., Haddrill, Justine L. and Lynch, Joseph W. (2001) Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the beta-amino acid agonist, taurine. Journal of Neurochemistry, 79 3: 636-647. doi:10.1046/j.1471-4159.2001.00601.x 30   18 Cited 19 times in Scopus19 0
Hallani, M, Lynch, JW and Barry, PH (1998) Characterization of calcium-activated chloride channels in patches excised from the dendritic knob of mammalian olfactory receptor neurons. Journal of Membrane Biology, 161 2: 163-171. doi:10.1007/s002329900323 38   45 Cited 43 times in Scopus43 0
Shan, Qiang and Lynch, Joseph W. (2010) Chimera construction using multiple-template-based sequential PCRs. Journal of Neuroscience Methods, 193 1: 86-89. doi:10.1016/j.jneumeth.2010.08.033 45   6 Cited 6 times in Scopus6 0
Yang, Zhe, Webb, Timothy I. and Lynch, Joseph W. (2007) Closed-state cross-linking of adjacent beta 1 Subunits in alpha 1 beta 1 GABA(a) receptors via introduced 6 ' cysteines. Journal of Biological Chemistry, 282 23: 16803-16810. doi:10.1074/jbc.M611555200 65   6 Cited 7 times in Scopus7 0
Lynch, Joseph W., Shan, Qiang and Haddrill, Justine (2003). Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors. In: Biophysical Journal:47th Annual Meeting Abstracts. 47th Annual Meeting of the Biophysical Society, San Antonio, Texas, USA, (87A-87A). 1-5 March, 2003. 50   0
Shan, Qiang, Haddrill, Justine L. and Lynch, Joseph W. (2002) Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors. Journal of Biological Chemistry, 277 47: 44845-44853. doi:10.1074/jbc.M208647200 43   22 Cited 22 times in Scopus22 0
Han, Nian-Lin R., Clements, John D. and Lynch, Joseph W. (2004). Comparison of glycine- and taurine-induced conformational changes in the glycine receptor M2-M3 domain. In: Molecular Structure in Ligand-Gated Ion Channel Function, Harlow, UK, (). 29 January 2004. 55  
Han, N. L. R., Clements, J. D. and Lynch, J. W. (2004) Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor. Journal of Biological Chemistry, 279 19: 19559-19565. doi:10.1074/jbc.M400548200 44   12 Cited 12 times in Scopus12 0
Balasubramanian, S, Lynch, JW and Barry, PH (1997) Concentration dependence of sodium permeation and sodium ion interactions in the cyclic AMP-gated channels of mammalian olfactory receptor neurons. Journal of Membrane Biology, 159 1: 41-52. doi:10.1007/s002329900267 51   6 Cited 7 times in Scopus7 0
Pless, Stephen A., Dibas, Mohammed I., Lester, Henry A. and Lynch, Joseph W. (2007) Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. Journal of Biological Chemistry, 282 49: 36057-36067. doi:10.1074/jbc.M706468200 78   38 Cited 42 times in Scopus42 0
Lynch, JW and Lindemann, B (1994) Cyclic Nucleotide-Gated Channels of Rat Olfactory Receptor-Cells - Divalent-Cations Control the Sensitivity to Camp. Journal of General Physiology, 103 1: 87-106. doi:10.1085/jgp.103.1.87 17   34 0
Delaney, A. J., Esmaeili, A., Sedlak, Petra L., Lynch, J. W. and Sah, P. (2010) Differential expression of glycine receptor subunits in the rat basolateral and central amygdala. Neuroscience Letters, 469 2: 237-242. doi:10.1016/j.neulet.2009.12.003 58   6 Cited 7 times in Scopus7 0
Chen, Xuebin, Cromer, Brett, Webb, Timothy I., Yang, Zhe, Hantke, Janina, Harvey, Robert J., Parker, Michael W. and Lynch, Joseph W. (2009) Dihydropyridine inhibition of the glycine receptor: Subunit selectivity and a molecular determinant of inhibition. Neuropharmacology, 56 1: 318-327. doi:10.1016/j.neuropharm.2008.07.001 62   5 Cited 7 times in Scopus7 0
Pless, Stephan and Lynch, Joseph W. (2009) Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits. Journal Of Neurochemistry, 108 6: 1585-1594. doi:10.1111/j.1471-4159.2009.05930.x 49   7 Cited 8 times in Scopus8 0
Shan, Qiang, Han, Lu and Lynch, Joseph W. (2012) Distinct properties of glycine receptor β+/α- interface: Unambiguously characterizing heteromeric interface reconstituted in homomeric protein. Journal of Biological Chemistry, 287 25: 21244-21252. doi:10.1074/jbc.M111.337741 58 2 1 Cited 1 times in Scopus1 0
Esmaeili, Abolghasem, Lynch, Joe and Sah, Pankaj (2006). Distribution and function of GABA(A) receptor subunits in the amygdala. In: Neuroscience Research: Abstracts for the 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006). The 29th Annual Meeting of the Japan Neuroscience Society - (Neuroscience2006), Kyoto, Japan, (S211-S211). 19-21 July 2006. doi:10.1016/j.neures.2006.04.004 138   0 Cited 0 times in Scopus0 0
Seebungkert, B. and Lynch, J. W. (2002) Effects of polyunsaturated fatty acids on voltage-gated K+ and Na+ channels in rat olfactory receptor neurons. European Journal of Neuroscience, 16 8: 2085-2094. doi:10.1046/j.1460-9568.2002.02288.x 46   17 Cited 18 times in Scopus18 0
Gebhardt, FM, Mitrovic, AD, Gilbert, DF, Vandenberg, RJ, Lynch, JW and Dodd, PR (2010) Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. Journal of Biological Chemistry, 285 41: 31313-31324. doi:10.1074/jbc.M110.153494 50   7 Cited 6 times in Scopus6 0
Talwar, Sahil, Lynch, Joseph W. and Gilbert, Daniel F. (2013) Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells. PLoS One, 8 3: e58479.1-e58479.11. doi:10.1371/journal.pone.0058479 31 10 1 Cited 1 times in Scopus1 0
Shan, Qiang, Han, Lu and Lynch, Joseph W. (2012) Function of hyperekplexia-causing alpha(1)R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signaling pathway. British Journal of Pharmacology, 165 7: 2113-2123. doi:10.1111/j.1476-5381.2011.01701.x 75 82 8 Cited 7 times in Scopus7 0
Dixon, Christine, Sah, Pankaj, Lynch, Joseph W. and Keramidas, Angelo (2014) GABAa receptor α and γ subunits shape synaptic currents via different mechanisms. Journal of Biological Chemistry, 289 9: 5399-5411. doi:10.1074/jbc.M113.514695 35   2 Cited 3 times in Scopus3 0
Esmaeili, Abolghasem, Lynch, Joseph W. and Sah, Pankaj (2009) GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala. Journal of Neurophysiology, 101 1: 341-349. doi:10.1152/jn.90991.2008 65   8 Cited 9 times in Scopus9 0
Chung, Seo-Kyung, Bode, Anna, Cushion, Thomas D., Thomas, Rhys H., Hunt, Charlotte, Wood, Sian-Elin, Pickrell, William O., Drew, Cheney J. G., Yamashita, Sumimasa, Shiang, Rita, Leiz, Steffen, Longhardt, Ann-Carolyn, Raile, Vera, Weschke, Bernhard, Puri, Ratna D., Verma, Ishwar C., Harvey, Robert J., Ratnasinghe, Didi D., Parker, Michael, Rittey, Chris, Masri, Amira, Lingappa, Lokesh, Howell, Owain W., Vanbellinghen, Jean-François, Mullins, Jonathan G., Lynch, Joseph W. and Rees, Mark I. (2013) GLRB is the third major gene of effect in hyperekplexia. Human Molecular Genetics, 22 5: 927-940. doi:10.1093/hmg/dds498 59 10 8 Cited 9 times in Scopus9 2
Lynch, JW and Callister, RJ (2006) Glycine receptors: A new therapeutic target in pain pathways. Current Opinion In Investigational Drugs, 7 1: 48-53. 53   46 Cited 52 times in Scopus52
Lynch, J. W. (2006) High-throughput screening of glycine and GAB(A)A receptors: Why and how?. Alcoholism-Clinical And Experimental Research, 30 9: 61A-61A. 43   0

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