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Michael Morgan, Taylor, Stephen M. and Shiels, I (2007) A C5a receptor antagonist provides greater protection than an NSAID in a skin pouch model of sodium urate induced inflammation. Molecular Immunology, 44 1-3: 217-217. doi:10.1016/j.molimm.2006.07.164 248   0 0
Woodruff, T. M., Proctor, L. M., Shiels, I. A. and Taylor, S. M. (2004). A cyclic peptide, C5a receptor antagonist analogue confers increased potency in a model of inflammatory bowel disease in rats. In: Molecular immunology: Abstracts of the 20th International Complement Workshop. 20th International Complement Workshop, Honolulu, Hawaii, (326-326). 13-18 June, 2004. doi:10.1016/j.molimm.2004.03.002 284   1 0
Shiels, I. A., Bowler, S. D. and Taylor, S. M. (1995) Airway smooth muscle proliferation in asthma: The potential of vascular leakage to contribute to pathogenesis. Medical Hypothesis, 45 1: 37-40. doi:10.1016/0306-9877(95)90198-1 56   17 Cited 17 times in Scopus17 0
Woodruff, T. M., Shiels, I. A., Fairlie, D. and Taylor, S. M. (2001). A new C5a receptor antagonist inhibits monoarticular arthritis in the rat. In: Proceedings of the Complement Associated Diseases, Animal Models and Therapeutics Workshop. Complement Assoc. Diseases, Animal Models & Ther. Workshop, Santorini, Greece, (37-37). 10-14 October, 2001. 80  
Woodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 9: 2476-2485. doi:10.1002/art.10449 103   75 Cited 74 times in Scopus74 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005) A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 5: 883-892. doi:10.1016/j.intimp.2005.01.003 91   21 Cited 26 times in Scopus26 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003) A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 10: 5514-5520. 97   75 Cited 75 times in Scopus75
Shiels, I. A., Sanderson, S. D. and Taylor, S. M. (1999) Arterially perfused eye model of uveitis. Australian Veterinary Journal, 77 2: 100-104. doi:10.1111/j.1751-0813.1999.tb11677.x 91   6 0
Arumugam, T. V., Shiels, I. A., Strachan, A. J., Abbenante, G., Fairlie, D. P. and Taylor, S. M. (2003) A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney International, 63 1: 134-142. doi:10.1046/j.1523-1755.2003.00737.x 116   101 Cited 109 times in Scopus109 0
Shiels, I. A., Taylor, S. M. and Fairlie, D. P. (2000) Cell phenotype as a target of drug therapy in chronic inflammatory diseases. Medical Hypotheses, 54 2: 193-197. doi:10.1054/mehy.1999.0017 58   7 Cited 7 times in Scopus7 0
Proctor, Lavinia M., Arumugam, Thiruma V., Shiels, Ian, Reid, Robert C., Fairlie, David P. and Taylor, Stephen M . (2004) Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology, 142 4: 756-764. doi:10.1038/sj.bjp.0705819 84   45 Cited 52 times in Scopus52 0
Coulthard, Liam G., Costello, Jaclyn, Robinson, Brent, Shiels, Ian A., Taylor, Stephen M. and Woodruff, Ttrent M. (2011) Comparative efficacy of a secretory phospholipase A(2) inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis. Arthritis Research & Therapy, 13 2: R42-1-R42-10. doi:10.1186/ar3278 79   8 Cited 9 times in Scopus9 0
Arumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003) Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 1: 71-80. doi:10.1038/sj.bjp.0705402 95   31 Cited 32 times in Scopus32 0
Hezmee, M. N. M., Shiels, I. A., Rolfe, B. E. and Mills, P. C. (2012) Complement C5a: Impact on the field of veterinary medicine. The Veterinary Journal, 192 3: 264-271. doi:10.1016/j.tvjl.2011.12.008 50   2 Cited 2 times in Scopus2 2
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011) Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 7: 2447-2455. doi:10.1096/fj.10-174284 68   28 Cited 29 times in Scopus29 0
Proctor, Lavinia M., Strachan, Anna J., Woodruff, Trent M., Mahadevan, Indumathy B., Williams, H. Ming, Shiels, Ian A. and Taylor, Stephen M. (2006) Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. International Immunopharmacology, 6 8: 1224-1232. doi:10.1016/j.intimp.2006.03.002 343   19 Cited 23 times in Scopus23 0
Arumugam, Thiruma V., Magnus, Tim, Woodruff, Trent M., Proctor, Lavinia M., Shiels, Ian A., Taylor, Stephen M., A. H. Wu and J. Delanghe (2006) Complement mediators in ischemia-reperfusion injury. Clinica Chimica Acta, 374 1-2: 33-45. doi:10.1016/j.cca.2006.06.010 69   61 Cited 64 times in Scopus64 0
Kotiw, Michael, Morgan, Michael, Taylor, Stephen M. and Shiels, Ian A. (2009) Detection of anti-TNFα activity in canine hyperimmune serum using a TNFα inhibition assay. Veterinary Clinical Pathology, 39 1: 46-52. doi:10.1111/j.1939-165X.2009.00166.x 59   1 Cited 1 times in Scopus1 0
Manthey, H., Taylor, S., Shiels, I. and Rolfe, B. (2007). Does C5a have a role in the pathophysiology of atherosclerosis?. In: W.-C. Song and X.-M. Gao, Molecular Immunology: Proceedings XXI International Complement Workshop. XXI International Complement Workshop, Beijing, China, (213-213). 22-26 October 2006. doi:10.1016/j.molimm.2006.07.154 126   0 0
Short, Anna, Wong, Allan K., Finch, Angela M., Haaima, Gerald, Shiels, Ian A., Fairlie, David P. and Taylor, Stephen M. (1999) Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. British Journal of Pharmacology, 126 2: 551-554. doi:10.1038/sj.bjp.0702338 46   51 Cited 56 times in Scopus56 0
Stewart, N. P., de Vos, A, J, and Shiels, I. (1990) Elimination of Theileria buffeli infections from cattle by concurrent treatment with primaquine phosphate and halofuginone lactate. Tropical animal health and production, 22 2: 109-115. doi:10.1007/BF02239835 100   7 Cited 4 times in Scopus4 0
Rogers, R. J. and Shiels, I. A. (1979) Epidemiology and control of anaplasmosis in Australia. Journal of The South African Veterinary Association-tydskrif Van Die Suid-afrikaanse Veterinere Vereniging, 50 4: 363-366. 43   20
Khor, Kuan Hua, Shiels, Ian A., Campbell, Fiona E., Greer, Ristan M., Rose, Annie and Mills, Paul C. (2014) Evaluation of a technique to measure heart rate variability in anaesthetised cats. Veterinary Journal, 199 2: 229-235. doi:10.1016/j.tvjl.2013.11.006 28   0 Cited 0 times in Scopus0 2
Stewart, N. P., de Vos, A. J., McGregor, W. and Shiels, I. (1987) Haemaphysalis humerosa, not H. longicornis, is the likely vector of Theileria buffeli in Australia. Australian Veterinary Journal, 64 9: 280-282. doi:10.1111/j.1751-0813.1987.tb15960.x 66   12 0
Adams, J. H., Shiels, I. A. and de Vos, A. J. (1989) Heterologous Antibody Responses of Calves to Anaplasma centrale ans A. marginale. Veterinary Parasitology, 31 1: 7-12. doi:10.1016/0304-4017(89)90003-4 44   6 Cited 4 times in Scopus4 0
Shiels, Ian A., Bowler, Simon D. and Taylor, Stephen M. (1996) Homologous serum increases fibronectin expression and cell adhesion in airway smooth muscle cells. Inflammation, 20 4: 373-387. doi:10.1007/BF01486740 40   7 0
Stocks, S. Z., Shiels, I. A. and Taylor, S. M. (1999) Homologous serum-stimulated fibronectin synthesis in human retinal pigmented epithelial cells. Australian and New Zealand Journal of Ophthalmology, 27 8: 247-249. doi:10.1046/j.1440-1606.1999.00199.x 39   3 Cited 4 times in Scopus4 0
Hezmee, Mnm, Kyaw-Tanner, M, Lee, JYP, Shiels, IA, Rolfe, B, Woodruff, T and Mills, PC (2011) Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors. Veterinary Immunology and Immunopathology, 139 1: 50-56. doi:10.1016/j.vetimm.2010.08.005 135   2 Cited 2 times in Scopus2 0
Woodruff, T. M., Pollitt, S., Proctor, L. M., Stocks, S. Z., Manthey, H. D., Williams, H. M., Mahadevan, I. B., Shiels, I. A. and Taylor, S. M. (2005) Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease. Journal of Pharmacology And Experimental Therapeutics, 314 2: 811-817. doi:10.1124/jpet.105.086835 71   33 Cited 34 times in Scopus34 0
Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and R. A. North (2001) Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. British Journal of Pharmacology, 134 12: 1778-1786. doi:10.1038/sj.bjp.0704417 81   44 0
Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001). British Journal of Pharmacology, 135 2: 579-580. doi:10.1038/sj.bjp.0704531 61   0 0
Bock, R. E., de Vos, A. J., Kingston, T. G., Shiels, I. A. and Dalgliesh, R. J. (1992) Investigations of breakdowns in protection provided by living Babesia bovis vaccine. Veterinary Parasitology, 43 1-2: 45-56. doi:10.1016/0304-4017(92)90047-D 46   54 Cited 47 times in Scopus47 0
Dimmock, C. K., Webster, W. R., Shiels, I. A. and Edwards, C. L. (1982) Isoimmune thrombocytopenic purpura in piglets. Australian Veterinary Journal, 59 5: 157-159. doi:10.1111/j.1751-0813.1982.tb02764.x 56   3 0
Wosu, L. O., Johnson, R. H., Smith, J. R. and Shiels, I. A. (1979) Isolation of rodent parvoviruses in Australia. Australian Veterinary Journal, 55 4: 201-202. doi:10.1111/j.1751-0813.1979.tb15287.x 27   1 0
Shiels, I. A. (1983) Liver biopsy in piglets using an anoscope and sponge forceps. Australian Veterinary Journal, 60 10: 317-318. doi:10.1111/j.1751-0813.1983.tb02828.x 39   0 0
Shiels, I. A. and Whitehouse, M. W. (2000) Lyprinol: Anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea. Allergie Et Immunologie, 32 7: 279-283. 90  
Khor, K. H., Campbell, F. E., Owen, Helen, Shiels, I. A. and Mills, P. C. (2015) Myocardial collagen deposition and inflammatory cell infiltration in cats with pre-clinical hypertrophic cardiomyopathy. Veterinary Journal, 203 2: 161-168. doi:10.1016/j.tvjl.2014.11.018 25   0 Cited 0 times in Scopus0 0
Taylor, Steve, Shiels, Ian Alexander and Fairlie, David (2003). New cyclic peptide or peptidomimetic compounds, are G-protein coupled receptor antagonists useful for treating inflammatory disorders such as rheumatoid arthritis, reperfusion injury or dermal inflammation. WO/2003/033528. 122 104
Moore, Tyson, Woodruff, Trent, Manthey, Helga, Monk, Peter, Taylor, Stephen and Shiels, Ian (2008). Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice. In: Robert Rieben, ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4150-4150). 28 September-2 October 2008. doi:10.1016/j.molimm.2008.08.165 94   0 0
Stewart, N. P., de Vos, A. J., McGregor, W. and Shiels, I. A. (1988) Observations on the development of tick transmitted Theileria Buffeli (syn Theileria Orientalis) in cattle. Research in Veterinary Science, 44 3: 338-342. 54   13
Morgan, Michael, Bulmer, Andrew C., Woodruff, Trent M., Proctor, Lavinia M., Williams, Hua M., Stocks, Shelli Z., Pollitt, Sandra, Taylor, Stephen M. and Shiels, Ian A (2008) Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration. European Journal of Pharmaceutical Sciences, 33 4-5: 390-398. doi:10.1016/j.ejps.2008.01.009 87   6 Cited 8 times in Scopus8 0
Arumugam, Thiruma V., Shiels, Ian A., Margolin, Solomon B., Taylor, Stephen M. and Brown, Lindsay (2002) Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine. Clinical And Experimental Pharmacology And Physiology, 29 11: 996-1000. doi:10.1046/j.1440-1681.2002.03766.x 59   18 Cited 20 times in Scopus20 0
Zhang, S., Shiels, I. A., Ambler, J. S. and Taylor, S. M. (1998). Pirfenidone reduces fibronectin synthesis by cultured human retinal pigment epithelial cells. In: Australian and New Zealand Journal of Ophthalmology: Australian Ophthalmic Visual Science Meeting 1997. Australian Ophthalmic Visual Science Meeting 1997, Canberra, Australia, (S74-S76). 6-7 December 1997. doi:10.1111/j.1442-9071.1998.tb01380.x 122   14 0
Lau, C., Ranasinghe, M. G., Shiels, I., Keates, H., Pasloske, K. and Bellingham, M. C. (2013) Plasma pharmacokinetics of alfaxalone after a single intraperitoneal or intravenous injection of Alfaxan((R)) in rats. Journal of Veterinary Pharmacology and Therapeutics, 36 5: 516-520. doi:10.1111/jvp.12055 42   3 Cited 1 times in Scopus1 0
Arumugum, T.V., Shiels, I. A., Fairlie, D. and Taylor, S. M. (2001). Prevention of ischemia/reperfusion injuries in rats by a new small molecule C5a receptor antagonist. In: Proceedings of the Complement Associated Diseases, Animal Models, and Therapeutics Workshop. Complement Associated Diseases, Animal Models and Ther. W/shop, Santorini, Greece, (47-47). 10-14 October 2001. 41  
Arumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004) Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 6: 934-941. doi:10.1016/j.jhep.2004.02.017 97   46 Cited 51 times in Scopus51 0
Arumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine. Journal of Surgical Research, 103 2: 260-267. doi:10.1006/jsre.2002.6369 68   70 Cited 73 times in Scopus73 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004) Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 1: 81-90. doi:10.1016/j.jss.2003.04.001 131   49 Cited 52 times in Scopus52 0
Manthey, Helga, Thomas, Anita, Taylor, Stephen, Woodruff, Trent, Moore, Tyson, Shiels, Ian and Rolfe, Barbara (2008). Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis. In: ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4151-4151). 28 September - 2 October 2008. doi:10.1016/j.molimm.2008.08.167 216   0 0
Jorgensen, W. K., Bock, R. E., De Vos, A. J. and Shiels, I. A. (1993) Sheep-adapted Anaplasma marginale maintains virulence for cattle. Australian Veterinary Journal, 70 5: 192-193. doi:10.1111/j.1751-0813.1993.tb06133.x 49   8 0

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