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Michael Morgan, Taylor, Stephen M. and Shiels, I (2007) A C5a receptor antagonist provides greater protection than an NSAID in a skin pouch model of sodium urate induced inflammation. Molecular Immunology, 44 1-3: 217-217. doi:10.1016/j.molimm.2006.07.164 244   0 0
Woodruff, T. M., Proctor, L. M., Shiels, I. A. and Taylor, S. M. (2004). A cyclic peptide, C5a receptor antagonist analogue confers increased potency in a model of inflammatory bowel disease in rats. In: Molecular immunology: Abstracts of the 20th International Complement Workshop. 20th International Complement Workshop, Honolulu, Hawaii, (326-326). 13-18 June, 2004. doi:10.1016/j.molimm.2004.03.002 278   1 0
Shiels, I. A., Bowler, S. D. and Taylor, S. M. (1995) Airway smooth muscle proliferation in asthma: The potential of vascular leakage to contribute to pathogenesis. Medical Hypothesis, 45 1: 37-40. doi:10.1016/0306-9877(95)90198-1 49   17 Cited 17 times in Scopus17 0
Woodruff, T. M., Shiels, I. A., Fairlie, D. and Taylor, S. M. (2001). A new C5a receptor antagonist inhibits monoarticular arthritis in the rat. In: Proceedings of the Complement Associated Diseases, Animal Models and Therapeutics Workshop. Complement Assoc. Diseases, Animal Models & Ther. Workshop, Santorini, Greece, (37-37). 10-14 October, 2001. 77  
Woodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 9: 2476-2485. doi:10.1002/art.10449 98   75 Cited 73 times in Scopus73 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005) A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 5: 883-892. doi:10.1016/j.intimp.2005.01.003 89   21 Cited 26 times in Scopus26 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003) A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 10: 5514-5520. 90   72 Cited 72 times in Scopus72
Shiels, I. A., Sanderson, S. D. and Taylor, S. M. (1999) Arterially perfused eye model of uveitis. Australian Veterinary Journal, 77 2: 100-104. doi:10.1111/j.1751-0813.1999.tb11677.x 88   6 0
Arumugam, T. V., Shiels, I. A., Strachan, A. J., Abbenante, G., Fairlie, D. P. and Taylor, S. M. (2003) A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney International, 63 1: 134-142. doi:10.1046/j.1523-1755.2003.00737.x 115   100 Cited 108 times in Scopus108 0
Shiels, I. A., Taylor, S. M. and Fairlie, D. P. (2000) Cell phenotype as a target of drug therapy in chronic inflammatory diseases. Medical Hypotheses, 54 2: 193-197. doi:10.1054/mehy.1999.0017 56   7 Cited 7 times in Scopus7 0
Proctor, Lavinia M., Arumugam, Thiruma V., Shiels, Ian, Reid, Robert C., Fairlie, David P. and Taylor, Stephen M . (2004) Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology, 142 4: 756-764. doi:10.1038/sj.bjp.0705819 83   43 Cited 50 times in Scopus50 0
Coulthard, Liam G., Costello, Jaclyn, Robinson, Brent, Shiels, Ian A., Taylor, Stephen M. and Woodruff, Ttrent M. (2011) Comparative efficacy of a secretory phospholipase A(2) inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis. Arthritis Research & Therapy, 13 2: R42-1-R42-10. doi:10.1186/ar3278 74   7 Cited 9 times in Scopus9 0
Arumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003) Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 1: 71-80. doi:10.1038/sj.bjp.0705402 93   30 Cited 32 times in Scopus32 0
Hezmee, M. N. M., Shiels, I. A., Rolfe, B. E. and Mills, P. C. (2012) Complement C5a: Impact on the field of veterinary medicine. The Veterinary Journal, 192 3: 264-271. doi:10.1016/j.tvjl.2011.12.008 47   2 Cited 2 times in Scopus2 2
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011) Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 7: 2447-2455. doi:10.1096/fj.10-174284 67   27 Cited 27 times in Scopus27 0
Proctor, Lavinia M., Strachan, Anna J., Woodruff, Trent M., Mahadevan, Indumathy B., Williams, H. Ming, Shiels, Ian A. and Taylor, Stephen M. (2006) Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. International Immunopharmacology, 6 8: 1224-1232. doi:10.1016/j.intimp.2006.03.002 341   17 Cited 19 times in Scopus19 0
Arumugam, Thiruma V., Magnus, Tim, Woodruff, Trent M., Proctor, Lavinia M., Shiels, Ian A., Taylor, Stephen M., A. H. Wu and J. Delanghe (2006) Complement mediators in ischemia-reperfusion injury. Clinica Chimica Acta, 374 1-2: 33-45. doi:10.1016/j.cca.2006.06.010 67   60 Cited 63 times in Scopus63 0
Kotiw, Michael, Morgan, Michael, Taylor, Stephen M. and Shiels, Ian A. (2009) Detection of anti-TNFα activity in canine hyperimmune serum using a TNFα inhibition assay. Veterinary Clinical Pathology, 39 1: 46-52. doi:10.1111/j.1939-165X.2009.00166.x 57   1 Cited 1 times in Scopus1 0
Manthey, H., Taylor, S., Shiels, I. and Rolfe, B. (2007). Does C5a have a role in the pathophysiology of atherosclerosis?. In: W.-C. Song and X.-M. Gao, Molecular Immunology: Proceedings XXI International Complement Workshop. XXI International Complement Workshop, Beijing, China, (213-213). 22-26 October 2006. doi:10.1016/j.molimm.2006.07.154 124   0 0
Short, Anna, Wong, Allan K., Finch, Angela M., Haaima, Gerald, Shiels, Ian A., Fairlie, David P. and Taylor, Stephen M. (1999) Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. British Journal of Pharmacology, 126 2: 551-554. doi:10.1038/sj.bjp.0702338 45   51 Cited 56 times in Scopus56 0
Stewart, N. P., de Vos, A, J, and Shiels, I. (1990) Elimination of Theileria buffeli infections from cattle by concurrent treatment with primaquine phosphate and halofuginone lactate. Tropical animal health and production, 22 2: 109-115. doi:10.1007/BF02239835 94   7 Cited 4 times in Scopus4 0
Rogers, R. J. and Shiels, I. A. (1979) Epidemiology and control of anaplasmosis in Australia. Journal of The South African Veterinary Association-tydskrif Van Die Suid-afrikaanse Veterinere Vereniging, 50 4: 363-366. 39   20
Khor, Kuan Hua, Shiels, Ian A., Campbell, Fiona E., Greer, Ristan M., Rose, Annie and Mills, Paul C. (2014) Evaluation of a technique to measure heart rate variability in anaesthetised cats. Veterinary Journal, 199 2: 229-235. doi:10.1016/j.tvjl.2013.11.006 23   0 Cited 0 times in Scopus0 1
Stewart, N. P., de Vos, A. J., McGregor, W. and Shiels, I. (1987) Haemaphysalis humerosa, not H. longicornis, is the likely vector of Theileria buffeli in Australia. Australian Veterinary Journal, 64 9: 280-282. doi:10.1111/j.1751-0813.1987.tb15960.x 61   11 0
Adams, J. H., Shiels, I. A. and de Vos, A. J. (1989) Heterologous Antibody Responses of Calves to Anaplasma centrale ans A. marginale. Veterinary Parasitology, 31 1: 7-12. doi:10.1016/0304-4017(89)90003-4 39   6 0
Shiels, Ian A., Bowler, Simon D. and Taylor, Stephen M. (1996) Homologous serum increases fibronectin expression and cell adhesion in airway smooth muscle cells. Inflammation, 20 4: 373-387. doi:10.1007/BF01486740 39   7 0
Stocks, S. Z., Shiels, I. A. and Taylor, S. M. (1999) Homologous serum-stimulated fibronectin synthesis in human retinal pigmented epithelial cells. Australian and New Zealand Journal of Ophthalmology, 27 8: 247-249. doi:10.1046/j.1440-1606.1999.00199.x 38   3 Cited 4 times in Scopus4 0
Hezmee, Mnm, Kyaw-Tanner, M, Lee, JYP, Shiels, IA, Rolfe, B, Woodruff, T and Mills, PC (2011) Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors. Veterinary Immunology and Immunopathology, 139 1: 50-56. doi:10.1016/j.vetimm.2010.08.005 131   2 Cited 2 times in Scopus2 0
Woodruff, T. M., Pollitt, S., Proctor, L. M., Stocks, S. Z., Manthey, H. D., Williams, H. M., Mahadevan, I. B., Shiels, I. A. and Taylor, S. M. (2005) Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease. Journal of Pharmacology And Experimental Therapeutics, 314 2: 811-817. doi:10.1124/jpet.105.086835 66   31 Cited 32 times in Scopus32 0
Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and R. A. North (2001) Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. British Journal of Pharmacology, 134 12: 1778-1786. doi:10.1038/sj.bjp.0704417 74   43 0
Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001). British Journal of Pharmacology, 135 2: 579-580. doi:10.1038/sj.bjp.0704531 55   0 0
Bock, R. E., de Vos, A. J., Kingston, T. G., Shiels, I. A. and Dalgliesh, R. J. (1992) Investigations of breakdowns in protection provided by living Babesia bovis vaccine. Veterinary Parasitology, 43 1-2: 45-56. doi:10.1016/0304-4017(92)90047-D 45   53 0
Dimmock, C. K., Webster, W. R., Shiels, I. A. and Edwards, C. L. (1982) Isoimmune thrombocytopenic purpura in piglets. Australian Veterinary Journal, 59 5: 157-159. doi:10.1111/j.1751-0813.1982.tb02764.x 54   3 0
Wosu, L. O., Johnson, R. H., Smith, J. R. and Shiels, I. A. (1979) Isolation of rodent parvoviruses in Australia. Australian Veterinary Journal, 55 4: 201-202. doi:10.1111/j.1751-0813.1979.tb15287.x 24   1 0
Shiels, I. A. (1983) Liver biopsy in piglets using an anoscope and sponge forceps. Australian Veterinary Journal, 60 10: 317-318. doi:10.1111/j.1751-0813.1983.tb02828.x 38   0 0
Shiels, I. A. and Whitehouse, M. W. (2000) Lyprinol: Anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea. Allergie Et Immunologie, 32 7: 279-283. 84  
Taylor, Steve, Shiels, Ian Alexander and Fairlie, David (2003). New cyclic peptide or peptidomimetic compounds, are G-protein coupled receptor antagonists useful for treating inflammatory disorders such as rheumatoid arthritis, reperfusion injury or dermal inflammation. WO/2003/033528. 117 104
Moore, Tyson, Woodruff, Trent, Manthey, Helga, Monk, Peter, Taylor, Stephen and Shiels, Ian (2008). Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice. In: Robert Rieben, ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4150-4150). 28 September-2 October 2008. doi:10.1016/j.molimm.2008.08.165 92   0 0
Stewart, N. P., de Vos, A. J., McGregor, W. and Shiels, I. A. (1988) Observations on the development of tick transmitted Theileria Buffeli (syn Theileria Orientalis) in cattle. Research in Veterinary Science, 44 3: 338-342. 47   13
Morgan, Michael, Bulmer, Andrew C., Woodruff, Trent M., Proctor, Lavinia M., Williams, Hua M., Stocks, Shelli Z., Pollitt, Sandra, Taylor, Stephen M. and Shiels, Ian A (2008) Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration. European Journal of Pharmaceutical Sciences, 33 4-5: 390-398. doi:10.1016/j.ejps.2008.01.009 85   5 Cited 6 times in Scopus6 0
Arumugam, Thiruma V., Shiels, Ian A., Margolin, Solomon B., Taylor, Stephen M. and Brown, Lindsay (2002) Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine. Clinical And Experimental Pharmacology And Physiology, 29 11: 996-1000. doi:10.1046/j.1440-1681.2002.03766.x 58   17 Cited 19 times in Scopus19 0
Zhang, S., Shiels, I. A., Ambler, J. S. and Taylor, S. M. (1998). Pirfenidone reduces fibronectin synthesis by cultured human retinal pigment epithelial cells. In: Australian and New Zealand Journal of Ophthalmology: Australian Ophthalmic Visual Science Meeting 1997. Australian Ophthalmic Visual Science Meeting 1997, Canberra, Australia, (S74-S76). 6-7 December 1997. doi:10.1111/j.1442-9071.1998.tb01380.x 118   13 0
Lau, C., Ranasinghe, M. G., Shiels, I., Keates, H., Pasloske, K. and Bellingham, M. C. (2013) Plasma pharmacokinetics of alfaxalone after a single intraperitoneal or intravenous injection of Alfaxan((R)) in rats. Journal of Veterinary Pharmacology and Therapeutics, 36 5: 516-520. doi:10.1111/jvp.12055 33   1 Cited 1 times in Scopus1 0
Arumugum, T.V., Shiels, I. A., Fairlie, D. and Taylor, S. M. (2001). Prevention of ischemia/reperfusion injuries in rats by a new small molecule C5a receptor antagonist. In: Proceedings of the Complement Associated Diseases, Animal Models, and Therapeutics Workshop. Complement Associated Diseases, Animal Models and Ther. W/shop, Santorini, Greece, (47-47). 10-14 October 2001. 38  
Arumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004) Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 6: 934-941. doi:10.1016/j.jhep.2004.02.017 94   46 Cited 51 times in Scopus51 0
Arumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine. Journal of Surgical Research, 103 2: 260-267. doi:10.1006/jsre.2002.6369 66   70 Cited 73 times in Scopus73 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004) Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 1: 81-90. doi:10.1016/j.jss.2003.04.001 130   49 Cited 50 times in Scopus50 0
Manthey, Helga, Thomas, Anita, Taylor, Stephen, Woodruff, Trent, Moore, Tyson, Shiels, Ian and Rolfe, Barbara (2008). Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis. In: ICW Basel, XXII International Complement Workshop, Basel, Switzerland, (4151-4151). 28 September - 2 October 2008. doi:10.1016/j.molimm.2008.08.167 206   0 0
Jorgensen, W. K., Bock, R. E., De Vos, A. J. and Shiels, I. A. (1993) Sheep-adapted Anaplasma marginale maintains virulence for cattle. Australian Veterinary Journal, 70 5: 192-193. doi:10.1111/j.1751-0813.1993.tb06133.x 47   8 0
Shiels, I. A., Bowler, S. D. and Taylor, S. M. (1999) The effects of salbutamol, beclomethasone, and dexamethasone on fibronectin expression by cultured airway smooth muscle cells. Inflammation, 23 4: 321-331. doi:10.1023/A:1020257532357 125   10 Cited 66 times in Scopus66 0

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