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Polasek, TM, Elliot, DJ, Somogyi, AA, Gillam, EMJ, Lewis, BC and Miners, JO (2006) An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid. British Journal of Clinical Pharmacology, 61 5: 570-584. doi:10.1111/j.1365-2125.2006.02627.x 107   32 Cited 35 times in Scopus35 0
Ho, M. K., Mwenifumbo, J. C., Zhao, B., Gillam, E. M. J. and Tyndale, R. F. (2008) A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. Pharmacogenetics and Genomics, 18 1: 67-75. doi:10.1097/FPC.0b013e3282f3606e 42   24 Cited 27 times in Scopus27 0
Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2007) A shuffled CYP1A library shows both structural integrity and functional diversity. Drug Metabolism And Disposition, 35 12: 2177-2185. doi:10.1124/dmd.107.017939 78   14 Cited 18 times in Scopus18 0
Huang, Weiliang, Johnston, Wayne A., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2007) A shuffled CYP2C library with a high degree of structural integrity and functional versatility. Archives of Biochemistry And Biophysics, 467 2: 193-205. doi:10.1016/j.abb.2007.08.023 84   17 Cited 21 times in Scopus21 0
Davies, C., Witham, K., Scott, J. R., Pearson, A., De Voss, J. J., Graham, S. E. and Gillam, E. M. J. (2004) Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9). Drug Metabolism and Disposition, 32 4: 431-436. doi:10.1124/dmd.32.4.431 76   17 Cited 15 times in Scopus15 0
Watanabe, J., Shimada, T., Gillam, E. M. J., Ikuta, T., Suemasu, K., Higashi, Y., Gotoh, O. and Kawajiri, K. (2000) Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetics, 10 1: 25-33. doi:10.1097/00008571-200002000-00004 55   124 Cited 145 times in Scopus145 0
Bidwell, L. M., Gillam, E. M. J., Gaedigk, A., Zhu, X., Grant, D. and McManus, M. E. (1998) Bacterial expression of two human aryl sulfotransferases. Chemico-biological Interactions, 109 1-3: 137-141. doi:10.1016/S0009-2797(97)00128-2 57 132 1 Cited 1 times in Scopus1 0
Munns, Andrew J., De Voss, James J., Hooper, Wayne D., Dickinson, Ronald G. and Gillam, Elizabeth M. J. (1997) Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation. Chemical Research In Toxicology, 10 9: 1049-1058. doi:10.1021/tx9700836 85   46 Cited 51 times in Scopus51 0
Notely, Lisa M., de Wolf, Cornelia J. F., Wunsch, Rebecca M., Lancaster, Roy G. and Gillam, Elizabeth M. J. (2002) Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology, 15 5: 614-622. doi:10.1021/tx0100439 91   36 Cited 38 times in Scopus38 0
Notley, L., De Wolf, C., Wunsch, R. and Gillam, E. M. J. (2001). Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymes. In: P.F.A. Wright, Toxicology: Abstracts of the IXth International Congress of Toxicology. IXth International Congress of Toxicology, Brisbane, Australia, (139-139). 8-12 July, 2001. doi:10.1016/S0300-483X(01)00386-9 213   0 0
Shimada, Tsutomu, Watanabe, Junko, Kawajiri, Kaname, Sutter, Thomas R., Guengerich, F. Peter, Gillam, Elizabeth M. J. and Inoue, Kiyoshi (1999) Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis, 20 8: 1607-1613. doi:10.1093/carcin/20.8.1607 28   205 Cited 210 times in Scopus210 0
Gillam, E and Ward, LC (1986) Cellular-Energy Charge in the Heart and Liver of the Rat - the Effects of Ethanol and Acetaldehyde. International Journal of Biochemistry, 18 11: 1031-1038. doi:10.1016/0020-711X(86)90249-1 23   17 Cited 11 times in Scopus11 0
Notley, L., Avent, K., Noble, C. J., Hanson, G. R. and Gillam, E. M. J. (2001). Characterization of chimeric mutant enzymes derived from P450S 3A4 and 3A5: catalytic and electron paramagnetic resonance (EPR) studies. In: R. Lange, 12th International Conference on Cytochrome P450. 12th International Conference on Cytochrome P450, La Grande Motte, France, (73-73). 11-15 September 2001. 48  
Notley, L., Avent, K., Noble, C. J., Hanson, G. R. and Gillam, E. M. J. (2001). Characterization of CYP3A4/3A5 chimeric enzymes: catalytic and electron paramagnetic resonance (EPR) studies. In: J.A. Hanson, Proceedings of the 6th International ISSX Meeting. 6th International ISSX Meeting, Munich, (90-90). 7-11 October 2001. 173  
Notley, LM, Crewe, KH, Taylor, PJ, Lennard, MS and Gillam, EMJ (2005) Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives. Chemical Research In Toxicology, 18 10: 1611-1618. doi:10.1021/tx050140s 61   19 Cited 20 times in Scopus20 0
Gillam, E. M. J. and Hunter, D. J. B. (2007). Chemical Defence and Exploitation: Biotransformation of Xenobiotics by Cytochrome P450 Enzymes. In Astrid Sigel, Helmut Sigel and Roland K. O. Sigel (Ed.), Metal Ions in Life Sciences (pp. 477-560) West Sussex: John Wiley and sons. 187  
Zaugg, Julian, Gumulya, Yosephine, Gillam, Elizabeth M. J. and Bodén, Mikael (2014). Computational tools for directed evolution: a comparison of prospective and retrospective strategies. In Elizabeth M. J. Gillam, Janine N. Copp and David F. Ackerley (Ed.), Directed evolution library creation: methods and protocols 2nd ed. (pp. 315-333) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-1053-3_21 47   0 0
Gillam, E. M. J. (2002) Coordinating clearance - the many phases of PXR!. Trends in Pharmacological Sciences, 23 548-549. 34  
Toselli, Francesca, Worrall, Simon, Wilce, Peter A., Dodd, Peter R. and Gillam, Elizabeth M. J. (2014). Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking. In: Abstracts from the 10th International ISSX Meeting. 10th International Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX), Toronto, Canada, (85-86). 29 September - 03 October 2013. 46   0
Guengerich, F. Peter, Chun, Young-Jin, Kim, Donghak, Gillam, Elizabeth M. J. and Shimada, Tsutomu (2003). Cytochrome P4501B1: a target for inhibition in anticarcinogenesis strategies. In: P. Stambrook, L. Mullenders and L. Ferguson, Mutation Research-Fundamental And Molecular Mechanisms of Mutagenesis. Proceedings of: Molecular Mechanisms and Chempreventive Potential. Conference on Dietary and Medicinal Antimutagens and Anticarcinogens, Seoul, South Korea, (173-182). 17-19 October, 2001. doi:10.1016/S0027-5107(02)00333-0 77   78 Cited 83 times in Scopus83 0
Matthias, A., Gillam, E. M. J., Penman, K. G., Matovic, N. J., Bone, K. M., De Voss, J. J. and Lehmann, R. P. (2005) Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes. Chemico-biological Interactions, 155 1-2: 62-70. doi:10.1016/j.cbi.2005.04.003 95   26 Cited 31 times in Scopus31 0
Johnston, Wayne A., Hunter, Dominic J. B., Noble, Christopher J., Hanson, Graeme R., Stok, Jeanette E., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2011) Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes. Journal of Biological Chemistry, 286 47: 40750-40759. doi:10.1074/jbc.M111.300871 119   3 Cited 4 times in Scopus4 0
Avent, Kathryn M., DeVoss, J. J. and Gillam, Elizabeth M. J. (2006) Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chemical Research In Toxicology, 19 7: 914-920. doi:10.1021/tx0600090 160   8 Cited 10 times in Scopus10 0
Kinobe, R. T., Dickinson, R. G. and Gillam, E. M. J. (2001). Deletion of glutathione S-transferase theta-1 (GSTT1) and anti-convulsant (ACD)-induced hypersensitivity syndrome. In: P.F.A. Wright, Proceedings of the IXth International Congress of Toxicology. IXth International Congress of Toxicology, Brisbane, (22-22). 8-12 July 2001. 64  
Depaz, Iris M. Booth, Toselli, Francesca, Wilce, Peter A. and Gillam, Elizabeth M. J. (2013) Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls. Drug Metabolism and Disposition, 41 6: 1187-1194. doi:10.1124/dmd.113.051359 38   2 Cited 3 times in Scopus3 0
Jackson, Colin J., Gillam, Elizabeth M. J. and Ollis, David L. (2010). Directed evolution of enzymes. In Lewis Mander and Hung-Wen Liu (Ed.), Comprehensive natural products II chemistry and biology (pp. 723-749) Oxford, England, Unied Kingdom: Elsevier. 39  
Rosic, Nedeljka, Lonhienne, Thierry G.A., DeVoss, James J. and Gillam, Elizabeth M.J. (2003). Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism. In: Drug Metabolism Reviews: Proceedings 8th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX). 8th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX), Dijon, France, (46-46). 27 April - 1 May, 2003. doi:10.1081/DMR-120020120 176   1 0
Behrendorff, James B. Y. H., Moore, Chad D., Kim, Keon-Hee, Kim, Dae-Hwan, Smith, Christopher A., Johnston, Wayne A., Yun, Chui-Ho, Yost, Garold S. and Gillam, Elizabeth M. J. (2012) Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli. Chemical Research in Toxicology, 25 9: 1964-1974. doi:10.1021/tx300281g 82   2 Cited 3 times in Scopus3 0
Shukla, Alka, Gillam, Elizabeth M., Mitchell, Deanne J. and Bernhardt, Paul V. (2005) Direct electrochemistry of enzymes from the cytochrome P4502C family. Electrochemistry Communications, 7 4: 437-442. doi:10.1016/j.elecom.2005.02.021 69   31 Cited 35 times in Scopus35 0
Shukla, Alka, Gillam, Elizabeth M. J. and Bernhardt, Paul V. (2006) Direct electrochemistry of human and rat NADPH cytochrome P450 reductase. Electrochemistry Communications, 8 12: 1845-1849. doi:10.1016/j.elecom.2006.08.020 100   3 Cited 3 times in Scopus3 0
Gillam, E. M. J. (2002) DNA–protein adducts: hijacking one repair process to examine another. Trends in Pharmacolgical Sciences, 23 5: 210-210. doi:10.1016/S0165-6147(02)02033-3 47   0
Behrendorff, James B. Y. H., Johnston, Wayne A. and Gillam, Elizabeth M. J. (2013). DNA shuffling of cytochrome P450 enzymes. In Ian R. Phillips, Elizabeth A. Shepherd and Paul R. Ortiz de Montellano (Ed.), Cytochrome P450 protocols 3rd ed. (pp. 177-188) New York, NY, United States: Humana Press. doi:10.1007/978-1-62703-321-3_16 44 9 Cited 0 times in Scopus0 0
Toselli, F., Matthias, A. and Gillam, E. M. J. (2009) Echinacea metabolism and drug interactions: The case for standardization of a complementary medicine. Life Sciences, 85 3-4: 97-106. doi:10.1016/j.lfs.2009.04.023 81   15 Cited 21 times in Scopus21 0
Sridar, C, Kent, UM, Notley, LM, Gillam, EMJ and Hollenberg, PF (2002) Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6. Journal of Pharmacology And Experimental Therapeutics, 301 3: 945-952. doi:10.1124/jpet.301.3.945 55   48 Cited 52 times in Scopus52 0
Gillam, E. M. J. (2008) Engineering cytochrome P450 enzymes. Chemical Research in Toxicology, 21 1: 220-231. doi:10.1021/tx7002849 75   50 Cited 55 times in Scopus55 0
Gillam, E. M. J., Notley, L., Guengerich, F. P., Shimada, T. and Lennard, M. S. (2000). Examining tissue-specific bioactivation in vitro: Cytochrome P450 1B1 and other extrahepatic forms in the metabolism of carcinogens. In: Pacifichem 2000 Proceedings. Pacifichem 2000 Proceedings, Honolulu, USA, (). 13 - 20 December, 2000. 66  
Gillam, EMJ and Guengerich, FP (2001) Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnology. Iubmb Life, 52 6: 271-277. doi:10.1080/152165401317291110 41   16 Cited 18 times in Scopus18 0
Gillam, Elizabeth M. J. (2005) Exploring the potential of xenobiotic-metabolising enzymes as biocatalysts: Evolving designer catalysts from polyfunctional cytochrome P450 enzymes. Clinical and Experimental Pharmacology and Physiology, 32 3: 147-152. doi:10.1111/j.1440-1681.2005.04165.x 60   19 Cited 21 times in Scopus21 0
Guengerich, F. P., Wheeler, J.B., Chun, Y.J., Kim, D., Shimada, T., Aryal, P., Oda, Y. and Gillam, E. M. J. (2001). Expressed P450s in toxicity assays. In: P.F.A. Wright, Toxicology: Abstracts of the IXth International Congress of Toxicology. 9th International Congress of Toxicology (ICT IX), Brisbane, Australia, (22-22). 8-12 July, 2001. doi:10.1016/S0300-483X(01)00386-9 43   0 0
Gillam, EMJ (2007) Extending the capabilities of nature's most versatile catalysts: Directed evolution of mammalian xenobiotic-metabolizing P450s. Archives of Biochemistry And Biophysics, 464 2: 176-186. doi:10.1016/j.abb.2007.04.033 67   18 Cited 21 times in Scopus21 0
Rosic, Nedeljka N., Huang, Weiliang, Johnston, Wayne A., DeVoss, James J. and Gillam, Elizabeth M.J. (2007) Extending the diversity of cytochrome P450 enzymes by DNA family shuffling. Gene, 395 1-2: 40-48. doi:10.1016/j.gene.2007.01.031 109   18 Cited 24 times in Scopus24 0
Hunter, D.J.B., Behrendorff, J.B.Y.H., Johnston, W.A., Hayes, P.Y., Huang, W., Bonn, B., Hayes, M.A., De Voss, J.J. and Gillam, E.M.J (2011) Facile production of minor metabolites for drug development using a CYP3A shuffled library. Metabolic Engineering, 13 6: 682-693. doi:10.1016/j.ymben.2011.09.001 71   6 Cited 8 times in Scopus8 0
Komatsu, T., Yamazaki, H., Asahi, S., Gillam, E. M. J., Guengerich, F. P., Nakajima, M. and Yokoi, T. (2000) Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P450 2C9, 2C19, and 3A4. Drug Metabolism and Disposition, 28 11: 1361-1368. 51   40
Kim, D., Gillam, E. M. J., Aguinaldo, A. M., Notley, L., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., De Voss, J. J. and Guengerich, F. P. (2000). Formation of indigo by recombinant mammalian cytochrome P450. In: V.T. Marchesi, Faseb Journal: ASBMB/ASPET 2000 Proceedings. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, (A1435-A1435). 4 - 8 June, 2000. 80   0
Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Kim, D., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., DeVoss, J. J. and Guengerich, F. P. (1999) Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications, 265 2: 469-472. doi:10.1006/bbrc.1999.1702 72   76 Cited 83 times in Scopus83 0
Warzecha, H, Frank, A, Peer, M, Gillam, EMJ, Guengerich, FP and Unger, M (2007) Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures. Plant Biotechnology Journal, 5 1: 185-191. doi:10.1111/j.1467-7652.2006.00231.x 103   9 Cited 10 times in Scopus10 9
Fairhead, M., Giannini, S., Gillam, E. M. J. and Gilardi, G. (2005) Functional characterisation of an engineered multidomain human P450 E1 by molecular Lego. Journal of Biological Inorganic Chemistry, 10 8: 842-853. doi:10.1007/s00775-005-0033-1 86   26 Cited 27 times in Scopus27 0
Kinobe, R., Dickinson, R. G. and Gillam, E. M. J. (2000). Genetic deletion of glutathione S-Transferases Theta-1 (GSTT1) and MU-1 (GSTM1) and the aromatic anticonvulsant drug-induced hypersensitivity syndrome. In: W.C. Hodgson and R.E. Loiacono, Proceedings of ASCEPT. ASCEPT Annual Scientific Meeting 2000, Newcastle, Australia, (107). 3 - 6 December, 2000. 49  
Gillam, E. M. J. (2001) Hang onto your haem....what's happened to CYP4A?. TRENDS in Pharmacological Sciences, 22 5: 220-220. 39  
Elliot, DJ, Suharjono, Lewis, BC, Gillam, EMJ, Birkett, DJ, Gross, AS and Miners, JO (2007) Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination. British Journal of Clinical Pharmacology, 64 4: 450-457. doi:10.1111/j.1365-2125.2007.02943.x 133   26 Cited 30 times in Scopus30 3

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