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Spielmann, Tobias, Hawthorne, Paula L., Dixon, Matthew W. A., Hannemann, Mandy, Klotz, Kathleen, Kemp, David J., Klonis, Nectarios, Tilley, Leann, Trenholme, Katharine R. and Gardiner, Donald L. (2006) A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell. Molecular Biology of the Cell, 17 8: 3613-3624. doi:10.1091/mbc.E06-04-0291 64   61 Cited 63 times in Scopus63 1
Peatey, Christopher L., Spicer, Timothy P., Hodder, Peter S., Trenholme, Katharine R. and Gardiner, Donald L. (2011) A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes. Molecular and Biochemical Parasitology, 180 2: 127-131. doi:10.1016/j.molbiopara.2011.09.002 40   23 Cited 23 times in Scopus23 1
Butterworth, Alice S., Robertson, Alan J., Ho, Mei-Fong, Gatton, Michelle L., McCarthy, James S. and Trenholme, Katharine R. (2011) An improved method for undertaking limiting dilution assays for in vitro cloning of Plasmodium falciparum parasites. Malaria Journal, 10 Article number 95: 1-5. doi:10.1186/1475-2875-10-95 88   4 Cited 5 times in Scopus5 3
Hawthorne, Paula L., Trenholme, Katharine R., Skinner-Adams, Tina S., Spielmann, Tobias, Fischer, Katja, Dixon, Matthew W. A., Ortega, Maria R., Anderson, Karen L., Kemp, David J. and Gardiner, Donald L. (2004) A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer's clefts. Molecular and Biochemical Parasitology, 136 2: 181-189. doi:10.1016/j.molbiopara.2004.03.013 118   54 Cited 50 times in Scopus50 0
Trenholme, Katharine R., Boutlis, Craig S., Kuns, Rachel, Lagog, Moses, Bockarie, Moses J., Gatton, Michelle L., Kemp, David J., Good, Michael F., Anstey, Nicholas M. and Gardiner, Donald L. (2005) Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea. American Journal of Tropical Medicine and Hygiene, 72 6: 708-713. 84   8 Cited 9 times in Scopus9
Thivierge, Karine, Mathew, Rency T., Nsangou, Desire M. M., Da Silva, Fabio, Cotton, Sophie, Skinner-Adams, Tina S., Trenholme, Katharine R., Brown, Christopher L., Stack, Colin M., Gardiner, Donald L. and Dalton, John P. (2012) Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases. Arkivoc, 2012 4: 330-346. doi:10.3998/ark.5550190.0013.424 19   1 Cited 1 times in Scopus1 0
Peatey, Christopher L., Andrews, Katherine T., Eickel, Nina, MacDonald, Timothy, Butterworth, Alice S., Trenholme, Katharine R., Gardiner, Donald L., McCarthy, James S. and Skinner-Adams, Tina S. (2010) Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors. Antimicrobial Agents and Chemotherapy, 54 3: 1334-1337. doi:10.1128/AAC.01512-09 87   13 Cited 21 times in Scopus21 0
Peatey, Christopher L., Leroy, Didier, Gardiner, Donald L. and Trenholme, Katharine R. (2012) Anti-malarial drugs: How effective are they against Plasmodium falciparum gametocytes?. Malaria Journal, 11 34: 34.1-34.4. doi:10.1186/1475-2875-11-34 56   15 Cited 16 times in Scopus16 5
McCarthy, James S., Sekuloski, Silvana, Griffin, Paul M., Elliott, Suzanne, Douglas, Nanette, Peatey, Chris, Rockett, Rebecca, O'Rourke, Peter, Marquart, Louise, Hermsen, Cornelius, Duparc, Stephan, Moehrle, Joerg, Trenholme, Katharine R. and Humberstone, Andrew J. (2011) A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs. PLoS ONE, 6 8: e21914-1-e21914-8. doi:10.1371/journal.pone.0021914 78   12 Cited 13 times in Scopus13 0
Stack, Colin M., Lowther, Jonathan, Cunningham, Eithne, Donnelly, Sheila, Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Teuscher, Franka, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Lua, Linda, Bell, Angus and Dalton, John P. (2007) Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. Journal of Biological Chemistry, 282 3: 2069-2080. doi:10.1074/jbc.M609251200 95   51 Cited 48 times in Scopus48 0
Gardiner, Donald L., Spielmann, Tobias, Dixon, Matthew W. A., Hawthorne, Paula L., Ortega, Maria R., Anderson, Karen L., Skinner-Adams, Tina S., Kemp, David J. and Trenholme, Katharine R. (2004) CLAG 9 is located in the rhoptries of Plasmodium falciparum. Parasitology Research, 93 1: 64-67. doi:10.1007/s00436-004-1098-4 87   0 Cited 17 times in Scopus17 0
Holt, Deborah C., Fischer, Katja, Tchavtchitch, Marina, Wilson, Danny W., Hauquitz, Nova E., Hawthorne, Paula L., Gardiner, Donald L., Trenholme, Katharine R. and Kemp, David J. (2001) Clags in Plasmodium falciparum and other species of Plasmodium. Molecular And Biochemical Parasitology, 118 2: 259-263. doi:10.1016/S0166-6851(01)00378-4 53   8 Cited 8 times in Scopus8 0
Skinner-Adams, Tina S., Lawrie, Paula M., Hawthorne, Paula L., Gardiner, Donald L. and Trenholme, Katharine R. (2003) Comparison of Plasmodium falciparum transfection methods. Malaria Journal, 2 19.1-19.4. doi:10.1186/1475-2875-2-19 102   6 Cited 6 times in Scopus6 0
Peatey, Christopher L., Skinner-Adams, Tina S., Dixon, Matthew W. A., McCarthy, James S., Gardiner, Donald L. and Trenholme, Katharine R. (2009) Effect of Antimalarial Drugs on Plasmodium falciparum Gametocytes. The Journal of Infectious Diseases, 200 10: 1518-1521. doi:10.1086/644645 60   31 Cited 35 times in Scopus35 0
Peatey, Christopher L., Watson, Jolanta A., Trenholme, Katharine R., Brown, Christopher L., Nielson, Lars, Guenther, Marko, Timmins, Nicholas, Watson, Gregory S. and Gardiner, Donald L. (2013) Enhanced gametocyte formation in erythrocyte progenitor cells: A site-specific adaptation by Plasmodium falciparum. The Journal of Infectious Diseases, 208 7: 1170-1174. doi:10.1093/infdis/jit309 39   Cited 2 times in Scopus2 1
Chung, Wendy Y., Gardiner, Donald L., Hyland, Catherine, Gatton, Michelle, Kemp, David J. and Trenholme, Katharine R. (2005) Enhanced invasion of blood group A1 erythrocytes by Plasmodium falciparum. Molecular and Biochemical Parasitology, 144 1: 128-130. doi:10.1016/j.molbiopara.2005.08.004 52   11 Cited 11 times in Scopus11 0
Poreba, Marcin, McGowan, Sheena, Skinner-Adams, Tina S., Trenholme, Katharine R., Gardiner, Donald L., Whisstock, James C., To, Joyce, Salvesen, Guy S., Dalton, John P. and Drag, Marcin (2012) Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. Plos One, 7 2: e31938-1-e31938-8. doi:10.1371/journal.pone.0031938 87   10 Cited 15 times in Scopus15 0
Skinner-Adams, Tina S., Hawthorne, Paula L., Trenholme, Katharine R. and Gardiner, Donald L. (2003) GATEWAY™ vectors for Plasmodium falciparum transfection. Trends in Parasitology, 19 1: 17-18. doi:10.1016/S1471-4922(02)00005-3 79   12 Cited 8 times in Scopus8 0
Skinner-Adams, Tina S., Lowther, Jonathan, Teuscher, Franka, Stack, Colin M., Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Trenholme, Katharine R., Dalton, John P. and Gardiner, Donald L. (2007) Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds. Journal of Medicinal Chemistry, 50 24: 6024-6031. doi:10.1021/jm070733v 46   39 Cited 39 times in Scopus39 0
Gardiner, Donald L., Dixon, Matthew W. A., Spielmann, Tobias, Skinner-Adams, Tina S., Hawthorne, Paula L., Ortega, Maria R., Kemp, David J. and Trenholme, Katharine R. (2005) Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis. Molecular and Biochemical Parasitology, 140 2: 153-160. doi:10.1016/j.molbiopara.2004.12.010 87   21 Cited 22 times in Scopus22 0
Chung, Wendy Y., Gardiner, Donald L., Hyland, Catharine and Trenholme, Katharine R. (2008) Invasion of Rh null cells by Plasmodium falciparum identifies a new invasion pathway. Parasitology Research, 102 2: 259-263. doi:10.1007/s00436-007-0756-8 58   2 Cited 2 times in Scopus2 0
Trenholme, Katharine, Marek, Linda, Duffy, Sandra, Pradel, Gabriele, Fisher, Gillian, Hansen, Finn K., Skinner-Adams, Tina S., Butterworth, Alice, Ngwa, Che Julius, Moecking, Jonas, Goodman, Christopher D., McFadden, Geoffrey I., Sumanadasa, Subathdrage D. M., Fairlie, David P., Avery, Vicky M., Kurz, Thomas and Andrews, Katherine T. (2014) Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules. Antimicrobial Agents and Chemotherapy, 58 7: 3666-3678. doi:10.1128/AAC.02721-13 17   2 Cited 2 times in Scopus2 4
Gardiner, D. L., McCarthy, J. S. and Trenholme, K. R. (2005) Malaria in the post-genomics era: light at the end of the tunnel or just another train?. Postgraduate Medical Journal, 81 958: 505-509. doi:10.1136/pgmj.2004.030304 43   10 Cited 9 times in Scopus9 0
Gardiner, Donald L., Skinner-Adams, Tina S., Spielmann, Tobias and Trenholme, Katharine R. (2003) Malaria transfection and transfection vectors. Trends In Parasitology, 19 9: 381-383. doi:10.1016/S1471-4922(03)00187-9 67   19 Cited 21 times in Scopus21 0
Spielmann, Tobias, Gardiner, Donald L., Beck, Hans-Peter, Trenholme, Katharine R and Kemp, David J. (2006) Organization of ETRAMPs and EXP-1 at the parasite-host cell interface of malaria parasites. Molecular Microbiology, 59 3: 779-794. doi:10.1111/j.1365-2958.2005.04983.x 63   35 Cited 37 times in Scopus37 0
Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Stack, Colin M. and Dalton, John P. (2006) Overexpression of Leucyl Aminopeptidase in Plasmodium falciparum Parasites. Target for the antimalarial activity of bestatin. Journal of Biological Chemistry, 281 3: 1741-1745. doi:10.1074/jbc.M508955200 54   42 Cited 41 times in Scopus41 1
Butterworth, Alice S., Skinner-Adams, Tina S., Gardiner, Don L. and Trenholme, Katharine R. (2013) Plasmodium falciparum gametocytes: With a view to a kill. Parasitology, 140 14: 1718-1734. doi:10.1017/S0031182013001236 30   3 Cited 3 times in Scopus3 2
Gardiner, Donald L., Skinner-Adams, Tina S., Brown, Christopher L., Andrews, Katherine T., Stack, Colin M., McCarthy, James S., Dalton, John P. and Trenholme, Katharine R. (2009) Plasmodium falciparum: New molecular targets with potential for antimalarial drug development. Expert Review of Anti-Infective Therapy, 7 9: 1087-1098. doi:10.1586/ERI.09.93 56   10 Cited 13 times in Scopus13 0
Jackson, Katherine E., Spielmann, Tobias, Hanssen, Eric, Adisa, Akinola, Separovic, Frances, Dixon, Matthew W. A., Trenholme, Katharine R., Hawthorne, Paula L., Gardiner, Don L., Gilberger, Tim and Tilley, Leann (2007) Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin 0 and equinatoxin II. Biochemical journal, 403 1: 167-175. doi:10.1042/BJ20061725 108   45 Cited 44 times in Scopus44 0
McGowan, Sheena, Porter, Corrine J., Lowther, Jonathan, Stack, Colin M., Golding, Sarah J., Skinner-Adams, Tina S., Trenholme, Katharine R., Teuscher, Franka, Donnelly, Sheila M., Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, DeGori, Ross, Buckle, Ashley M., Gardiner, Donald L., Whisstock, James C. and Dalton, John P. (2009) Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proceedings of the National Academy of Sciences of USA, 106 8: 2537-2542. doi:10.1073/pnas.0807398106 33   58 Cited 59 times in Scopus59 7
Hanssen, Eric, Hawthorne, Paula, Dixon, Matthew W. A., Trenholme, Katharine R, McMillan, Paul J., Spielmann, Tobias, Gardiner, Donald L. and Tilley, Leann (2008) Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles. Molecular Microbiology, 69 4: 938-953. doi:10.1111/j.1365-2958.2008.06329.x 78   33 Cited 33 times in Scopus33 0
Dixon, Matthew W. A., Hawthorne, Paula L., Spielmann, Tobias, Anderson, Karen L., Trenholme, Katharine R. and Gardiner, Donald L. (2008) Targeting of the ring exported protein 1 to the Maurer's Clefts is mediated by a two-phase process. Traffic, 9 8: 1316-1326. doi:10.1111/j.1600-0854.2008.00768.x 75   33 Cited 37 times in Scopus37 0
Skinner-Adams, Tina S., Peatey, Christopher L., Anderson, Karen, Trenholme, Katharine R., Krige, David, Brown, Christopher L., Stack, Colin, Nsangou, Desire M. M., Mathews, Rency T., Thivierge, Karine, Dalton, John P. and Gardinerd, Donald L. (2012) The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria. Antimicrobial Agents and Chemotherapy, 56 6: 3244-3249. doi:10.1128/AAC.06245-11 40   6 Cited 6 times in Scopus6 1
Trenholme, K. R., Teuscher, F., Skinner-Adams, T. S., Stack, C. M., Dalton, J. P. and Gardiner, D. L. (2008). The aspartyl aminopeptidase of Plasmodium falciparum. In: MAM 2008. Molecular Approaches to Malaria (MAM) 2008, Lorne, VIC, Australia, (S39-S40). 3-7 February 2008. doi:10.1016/S0020-7519(07)00459-6 105   1 0
Sivaraman, Komagal Kannan, Oellig, Christine A., Huynh, Kitmun, Atkinson, Sarah C., Poreba, Marcin, Perugini, Matthew A., Trenholme, Katharine R., Gardiner, Donald L., Salvesen, Guy, Drag, Marcin, Dalton, John P., Whisstock, James C. and McGowan, Sheena (2012) X-ray crystal structure and specificity of the plasmodium falciparum malaria aminopeptidase PfM18AAP. Journal of Molecular Biology, 422 4: 495-507. doi:10.1016/j.jmb.2012.06.006 48   8 Cited 6 times in Scopus6 1