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Kompella, Shiva N., Hung, Andrew, Clark, Richard J. and Adams, David J. (2013). alpha-Conotoxin Regiia Targeting Nicotinic Acetylcholine Receptors: Mutagenesis Studies Improving Selectivity and Potency. In: Abstracts of the 57th Annual Meeting of the Biophysical Society. 57th Annual Meeting of the Biophysical Society, Philadelphia Pa, (634A-634A). 02-06 February 2013. doi:10.1016/j.bpj.2012.11.3505 31   0 0
Callaghan, Brid, Haythornthwaite, Alison R., Berecki, Geza, Clark, Richard J., Craik, David J. and Adams, David J. (2008) Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activation. The Journal of Neuroscience, 28 43: 10943-10951. doi:10.1523/JNEUROSCI.3594-08.2008 141   65 Cited 68 times in Scopus68 0
Gruber, C. W, Cemazar, M., Clark, R. .J, Horibe, T, Renda, R. F., Anderson, M. A. and Craik, D. J. (2007) A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins. Journal of Biological Chemistry, 282 28: 20435-20446. doi:10.1074/jbc.M700018200 128   53 Cited 55 times in Scopus55 0
Rosengren, KJ, Jen, FEC, Clark, RJ, Goransson, U, Daly, NL and Craik, DJ (2005). A novel threaded ring structure for the antimicrobial peptide microcin J25. In: Martin Flegel, Peptides 2004: Bridges between Disciplines ; Proceedings of the Third International and Twenty-Eighth European Peptide Symposium. Peptides 2004: 3rd International Peptide Symposium / 28th European Peptide Symposium, Prague, Czech Republic, (174-175). 5 - 10 September 2004. 103   0
Craik, D. J., Rosengren, K. J., Clark, R. J., Daly, N. L. and Goransson, U. (2004). A novel threaded ring structure for the antimicrobial peptide microcin J25. In: Oral Presentation Abstracts P91–P118. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, (116-116). 5–10 September 2004. doi:10.1002/psc.617 55   0 0
Clark, R. J., Garson, M. J. and Hooper, J. N. A. (2001) Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.. Journal of Natural Products, 64 12: 1568-1571. doi:10.1021/np010246x 77   34 Cited 39 times in Scopus39 0
Nevin, Simon T., Clark, Richard J., Klimis, H., Christie, M. J., Craik, David J. and Adams, David J. (2007) Are alpha 9 alpha 10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?. Molecular Pharmacology, 72 6: 1406-1410. doi:10.1124/mol.107.040568 165   51 Cited 53 times in Scopus53 0
Green, K. M., Russell, B. D., Clark, R. J., Jones, M. K ., Garson, M. J., Skilleter, G. A. and Degnan, B. M. (2002) A sponge allelochemical induces ascidian settlement but inhibits metamorphosis. Marine Biology, 140 2: 355-363. doi:10.1007/s002270100698 97   25 Cited 24 times in Scopus24 0
Armishaw, Christopher J., Singh, Narender, Medina-Franco, Jose L., Clark, Richard J., Scott, Krystle C. M., Houghten, Richard A. and Jensen, Anders A. (2009) A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. Journal of Biological Chemistry, 285 3: 1809-1821. doi:10.1074/jbc.M109.071183 76   25 Cited 22 times in Scopus22 0
Lattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009) Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 2-3: 340-347. doi:10.1016/j.molimm.2009.09.012 98   6 Cited 9 times in Scopus9 0
Westermann, Jan, Clark, Richard J. and Craik, David J. (2008) Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMR. Protein And Peptide Letters, 15 9: 910-914. doi:10.2174/092986608785849335 60   4 Cited 4 times in Scopus4 0
Akcan, M, Stroud, MR, Hansen, SJ, Clark, RJ, Daly, NL, Craik, DJ and Olson, JM (2011) Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. Journal of Medicinal Chemistry, 54 3: 782-787. doi:10.1021/jm101018r 83   22 Cited 21 times in Scopus21 2
Dutton, J. L., Renda, R. F., Waine, C., Clark, R. J., Daly, N. L., Jennings, C. V., Anderson, M. A. and Craik, D. J. (2004) Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. Journal of Biological Chemistry, 279 45: 46858-46867. doi:10.1074/jbc.M407421200 76   78 Cited 73 times in Scopus73 0
Clark, Richard J., Akcan, Muharrem, Kaas, Quentin, Daly, Norelle L. and Craik, David J. (2012) Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon, 59 4: 446-455. doi:10.1016/j.toxicon.2010.12.003 124   19 Cited 18 times in Scopus18 0
Craik, David J., Clark, Richard J. and Daly, Norelle L. (2008) Cyclotides and conotoxins ultra-stable disulfide-rich peptides. Chimica Oggi -Chemistry Today, 26 4: 20-22. 51   1 Cited 1 times in Scopus1
Plan, MR, Goransson, U, Rosengren, KJ, Clark, RJ, Daly, NL, Evert, P, Chen, C, Cagauan, AG and Craik, DJ (2004). Cyclotides: Novel Peptidic Pesticides for Plant Protection. In: Journal of Peptide Science. , , (278-278). . 35   0
Clark, Richard J., Preza, Gloria C., Tan, Chia Chia, van Dijk, Johannes W. A., Fung, Eileen, Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2013) Design, synthesis and characterisation of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers: Peptide Science, 100 5: 519-526. doi:10.1002/bip.22350 45   5 0
Haugaard-Kedström, Linda M., Shabanpoor, Fazel, Hossain, Mohammed Akhter, Clark, Richard J., Ryan, Philip J., Craik, David J., Gundlach, Andrew L., Wade, John D., Bathgate, Ross A. D. and Rosengren, K. Johan (2011) Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. Journal of the American Chemical Society, 133 13: 4965-4974. doi:10.1021/ja110567j 94   20 Cited 25 times in Scopus25 0
Clark, RJ, Dempster, L, Daly, NL, Rosengren, KJ and Craik, DJ (2004). Design, Synthesis and Structural Studies of Cyclic Alpha-Conotoxins. In: Journal of Peptide Science. , , (269-269). . 33   0
Adams, D. J., Berecki, G., Clark, R. and Craik, D. J. (2013). Development of analgesic alpha-conotoxins for treatment of chronic pain. In: Special Issue: ACABS 2013: The Fourth Meeting of The Australia Chinese Association for Biomedical Sciences Inc. 4th Meeting of the Australia Chinese Association for Biomedical Sciences Inc (ACABS), Hangzhou Peoples R China, (4-4). 10-13 October 2013. doi:10.1111/1440-1681.12170 110   0 0
Berecki, Géza, McArthur, Jeffrey R., Cuny, Hartmut, Clark, Richard J. and Adams, David J. (2014) Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. Journal of General Physiology, 143 4: 465-479. doi:10.1085/jgp.201311104 18   2 Cited 3 times in Scopus3 70
Craik, David J., Anderson, Marilyn A., Barry, Daniel G., Clark, Richard J., Daly, Norelle L., Jennings, Cameron V. and Mulvenna, Jason P. (2001) Discovery and structures of the cyclotides: novel macrocyclic peptides from plants. Letters in Peptide Science, 8 3-5: 119-128. doi:10.1007/BF02446507 89   3 Cited 20 times in Scopus20 0
Gunasekera, Sunithi, Daly, Norelle L., Clark, Richard J. and Craik, David J. (2009) Dissecting the oxidative folding of circular cystine knot miniproteins. Antioxidants and Redox Signalling, 11 5: 971-980. doi:10.1089/ars.2008.2295 91 47 23 Cited 23 times in Scopus23 0
Korsinczky, M. L. J., Clark, R. J. and Craik, D. J. (2005) Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1. Biochemistry, 44 4: 1145-1153. doi:10.1021/bi048297r 73   25 Cited 21 times in Scopus21 0
Daly, N. L., Clark, R. J. and Craik, D. J. (2003) Disulfide folding pathways of cystine knot proteins: Tying the knot within the circular backbone of the cyclotides. The Journal of Biological Chemistry, 278 8: 6314-6322. doi:10.1074/jbc.M210492200 85   79 Cited 80 times in Scopus80 0
Daly, N. L., Clark, R. J., Goransson, U. and Craik, D. J. (2003) Diversity in the disulfide folding pathways of cystine knot peptides. Letters in Peptide Science, 10 5-6: 523-531. doi:10.1007/BF02442584 65   8 Cited 6 times in Scopus6 0
Garson, M. J., Clark, R., Webb, R. I., Field, K. L. and Charan, R. D. (1999). Ecological role of cytotoxic alkaloids: Haliclona n.sp., an unusual sponge/dinoflagellate association. In: Memoirs of the Queensland Museum. 5th International Sponge Conference, Brisbane, (205-213). 27 June - 4 July 1999. 87  
Halai, Reena, Callaghan, Brid, Daly, Norelle L., Clark, Richard J., Adams, David J. and Craik, David J. (2011) Effects of cyclization on stability, structure, and activity of alpha-conotoxin RgIA at the alpha 9 alpha 10 nicotinic acetylcholine receptor and GABA(B) receptor. Journal of Medicinal Chemistry, 54 19: 6984-6992. doi:10.1021/jm201060r 74   13 Cited 12 times in Scopus12 0
Clark, Richard J. and Craik, David J. (2012) Engineering cyclic peptide toxins. Methods in Enzymology, 503 57-74. doi:10.1016/B978-0-12-396962-0.00003-3 81   13 Cited 11 times in Scopus11 2
Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2011) Engineering of conotoxins for the treatment of pain. Current Pharmaceutical Design, 17 38: 4242-4253. 90 2 17 Cited 7 times in Scopus7
Chan, Lai Y., Gunasekera, Sunithi, Henriques, Sonia T., Worth, Natalie F., Le, Sarah-Jane, Clark, Richard J., Campbell, Julie H., Craik, David J. and Daly, Norelle L. (2011) Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds. Blood, 118 25: 6709-6717. doi:10.1182/blood-2011-06-359141 62   44 Cited 43 times in Scopus43 1
Chan, L. A., Gunasekera, S., Henriques, S. T., Worth, N. F., Le, S., Clark, R. J., Campbell, J. H., Craik, D. J. and Daly, N. L. (2012). Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds. In: 32nd European Peptide Symposium, Athens, Greece, (S40-S40). 2-7 September 2012. doi:10.1002/psc.2448 37   0 0
Clark, R. J., Fischer, H., Dempster, L., Daly, N. L., Rosengren, K. J., Nevin, S. T., Meunier, F. A., Adams, D. J. and Craik, D. J. (2005) Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the alpha-conotoxin MII. Proceedings of The National Academy of Sciences of The United States of America, 102 39: 13767-13772. doi:10.1073/pnas.0504613102 77   100 Cited 100 times in Scopus100 0
Gunasekera, Sunithi, Foley, Fiona M., Clark, Richard J., Sando, Lillian, Fabri, Louis J., Craik, David J. and Daly, Norelle L. (2008) Engineering stablized vascular endothelial growth factor-A antagonists: synthesis, structural characterization and bioactivity of grafted analogues of cyclotides. Journal of Medicinal Chemistry, 51 24: 7697-7704. doi:10.1021/jm800704e 61   80 Cited 79 times in Scopus79 0
Gruber, G. W., Cemazar, M., Clark, R., Horibe, T., Renda, R., Anderson, M. A. and Craik, D. J. (2007). Enzyme mechanism and function of a novel plant protein disulfide isomerase involved in the oxidative folding of cystine knot defence peptides. In: Susan Del Valle, Emanuel Escher and William D. Lubell, Biopolymers. 20th American-Peptide-Society Symposium, Montréal, Canada, (541-541). 26-30 Jun 2007. doi:10.1002/bip.20783 196   0 0
Akcan, Muharrem, Stroud, Mark R., Hansen, Stacey J., Clark, Richard J., Daly, Norelle L., Craik, David J. and Olson, James M. (2013) Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r). Journal of Medicinal Chemistry, 56 23: 9807-9807. doi:10.1021/jm4016119 36   0 Cited 0 times in Scopus0 0
Burman, Robert, Svedlund, Erika, Felth, Jenny, Hassan, Saadia, Hermann, Anders, Clark, Richard James, Craik, David J., Bohlin, Lars, Claeson, Per, Goransson, Ulf and Gullbo, Joachim (2010). Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice. In: Proceedings of the 1st International Conference on Circular Proteins. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, (626-634). 18-21 October, 2009. doi:10.1002/bip.21408 90   12 Cited 12 times in Scopus12 0
Grishin, Anton A., Cuny, Hartmut, Hung, Andrew, Clark, Richard J., Brust, Andreas, Akondi, Kalyana, Alewood, Paul F., Craik, David J. and Adams, David J. (2013) Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288 48: 34428-34442. doi:10.1074/jbc.M113.512582 71 2 4 Cited 5 times in Scopus5 0
Millard, Emma L., Nevin, Simon T., Loughnan, Marion L., Nicke, Annette, Clark, Richard J., Alewood, Paul F., Lewis, Richard J., Adams, David J., Craik, David J. and Daly, Norelle L. (2009) Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues. Journal of Biological Chemistry, 284 8: 4944-4951. doi:10.1074/jbc.M804950200 92   17 Cited 17 times in Scopus17 0
Aboye, Teshome Leta, Clark, Richard J., Burman, Robert, Roig, Marta Bajona, Craik, David J. and Goransson, Ulf (2011) Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of Cyclotides. Antioxidants & Redox Signaling, 14 1: 77-86. doi:10.1089/ars.2010.3112 77 39 17 Cited 14 times in Scopus14 0
Ireland, David C., Clark, Richard J., Daly, Norelle L. and Craik, David J. (2010) Isolation, sequencing, and structure - Activity relationships of cyclotides. Journal of Natural Products, 73 9: 1610-1622. doi:10.1021/np1000413 59   28 Cited 26 times in Scopus26 0
Daly, N. L., Clark, R. J., Plan, M. R. and Craik, D. J. (2006) Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochemical Journal, 393 Part 3: 619-626. doi:10.1042/BJ20051371 63   54 Cited 51 times in Scopus51 0
Barry, D. G., Daly, N. L., Clark, R. J., Sando, L. and Craik, D. J. (2003) Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry, 42 22: 6688-6695. doi:10.1021/bi027323n 57   72 Cited 67 times in Scopus67 0
Huang, Yen-Hua (黃彥華), Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C. and Craik, David J. (2010) Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. Journal of Biological Chemistry, 285 14: 10797-10805. doi:10.1074/jbc.M109.089854 68   37 Cited 37 times in Scopus37 0
Garson, M. J., Blunt, J. W., Clark, R., Degnan, B. M., Green, K. M., Munro, M. H., Simpson, J. and Skilleter, G. A. (2000). Marine ecology: The natural approach to finding bioactives. In: Australasian Biotechnological Association Conference. Australasian Biotechnological Association Conference, Brisbane, (). 2-6 July, 2000. 74  
Rosengren, K. J., Clark, R. J., Daly, N. L., Goransson, U., Jones, A. and Craik, D. J. (2003) Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Journal of the American Chemical Society, 125 41: 12464-12474. doi:10.1021/JA0367703 89   129 Cited 119 times in Scopus119 0
Halai, R., Clark, R., Nevin, S., Adams, D. and Craik, D. (2009). Mutational atudies on alpha-conotoxin VCL1. In: Abstracts of the 21st American Peptide Symposium. 21st American Peptide Symposium, Bloomington, Indiana, USA, (315-315). 7-12 June 2009. doi:10.1002/bip.21223 48   0 0
Clark, Richard J. and Craik, David J. (2010) Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins. Biopolymers, 94 4: 414-422. doi:10.1002/bip.21372 79   40 Cited 41 times in Scopus41 0
Clark, Richard J., Stapleton, Bronwin L. and Garson, Mary J. (2000) New Isocyano and Isothiocyanato Terpene Metabolites from the Tropical Marine Sponge Acanthella cavernosa. Tetrahedron, 56 19: 3071-3076. doi:10.1016/S0040-4020(00)00226-X 45   19 Cited 19 times in Scopus19 0
Craik, D. J. and Clark, R. J. (2003). NMR and Drug Discovery. In Donald J Abraham (Ed.), Burger's Medicinal Chemistry and Drug Discovery, Vol 1, Drug Discovery 6th ed. (pp. 507-582) USA: John Wiley & Sons. 60  

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