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Kompella, Shiva N., Hung, Andrew, Clark, Richard J., Mari, Frank and Adams, David J. (2015) Alanine scan ofα-conotoxin regIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist. Journal of Biological Chemistry, 290 2: 1039-1048. doi:10.1074/jbc.M114.605592 13   0 Cited 0 times in Scopus0 40
Kompella, Shiva N., Hung, Andrew, Clark, Richard J. and Adams, David J. (2013). alpha-Conotoxin Regiia Targeting Nicotinic Acetylcholine Receptors: Mutagenesis Studies Improving Selectivity and Potency. In: Abstracts of the 57th Annual Meeting of the Biophysical Society. 57th Annual Meeting of the Biophysical Society, Philadelphia Pa, (634A-634A). 02-06 February 2013. doi:10.1016/j.bpj.2012.11.3505 38   0 0
Callaghan, Brid, Haythornthwaite, Alison R., Berecki, Geza, Clark, Richard J., Craik, David J. and Adams, David J. (2008) Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activation. The Journal of Neuroscience, 28 43: 10943-10951. doi:10.1523/JNEUROSCI.3594-08.2008 147   69 Cited 70 times in Scopus70 0
Clark, R. J., Carstens, B. B., Berecki, G., Callaghan, B., Adams, D. J. and Craik, D. J. (2013). A New Target for the Alpha-Conotoxins: The GABAB Receptor. In: Biopolymers. 23rd American Peptide Symposium, Waikoloa Hi, (247-247). Jun 22-27, 2013. 21   0
Gruber, C. W, Cemazar, M., Clark, R. .J, Horibe, T, Renda, R. F., Anderson, M. A. and Craik, D. J. (2007) A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins. Journal of Biological Chemistry, 282 28: 20435-20446. doi:10.1074/jbc.M700018200 135   56 Cited 56 times in Scopus56 0
Rosengren, KJ, Jen, FEC, Clark, RJ, Goransson, U, Daly, NL and Craik, DJ (2005). A novel threaded ring structure for the antimicrobial peptide microcin J25. In: Martin Flegel, Peptides 2004: Bridges between Disciplines ; Proceedings of the Third International and Twenty-Eighth European Peptide Symposium. Peptides 2004: 3rd International Peptide Symposium / 28th European Peptide Symposium, Prague, Czech Republic, (174-175). 5 - 10 September 2004. 110   0
Craik, D. J., Rosengren, K. J., Clark, R. J., Daly, N. L. and Goransson, U. (2004). A novel threaded ring structure for the antimicrobial peptide microcin J25. In: Oral Presentation Abstracts P91–P118. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, (116-116). 5–10 September 2004. doi:10.1002/psc.617 60   0 0
Clark, R. J., Garson, M. J. and Hooper, J. N. A. (2001) Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.. Journal of Natural Products, 64 12: 1568-1571. doi:10.1021/np010246x 80   34 Cited 40 times in Scopus40 0
Nevin, Simon T., Clark, Richard J., Klimis, H., Christie, M. J., Craik, David J. and Adams, David J. (2007) Are alpha 9 alpha 10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?. Molecular Pharmacology, 72 6: 1406-1410. doi:10.1124/mol.107.040568 170   52 Cited 55 times in Scopus55 0
Green, K. M., Russell, B. D., Clark, R. J., Jones, M. K ., Garson, M. J., Skilleter, G. A. and Degnan, B. M. (2002) A sponge allelochemical induces ascidian settlement but inhibits metamorphosis. Marine Biology, 140 2: 355-363. doi:10.1007/s002270100698 106   25 Cited 24 times in Scopus24 0
Armishaw, Christopher J., Singh, Narender, Medina-Franco, Jose L., Clark, Richard J., Scott, Krystle C. M., Houghten, Richard A. and Jensen, Anders A. (2009) A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. Journal of Biological Chemistry, 285 3: 1809-1821. doi:10.1074/jbc.M109.071183 84   26 Cited 25 times in Scopus25 0
Lattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009) Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 2-3: 340-347. doi:10.1016/j.molimm.2009.09.012 108   6 Cited 9 times in Scopus9 0
Westermann, Jan, Clark, Richard J. and Craik, David J. (2008) Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMR. Protein And Peptide Letters, 15 9: 910-914. doi:10.2174/092986608785849335 62   4 Cited 4 times in Scopus4 0
Akcan, M, Stroud, MR, Hansen, SJ, Clark, RJ, Daly, NL, Craik, DJ and Olson, JM (2011) Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. Journal of Medicinal Chemistry, 54 3: 782-787. doi:10.1021/jm101018r 87   23 Cited 22 times in Scopus22 2
Dutton, J. L., Renda, R. F., Waine, C., Clark, R. J., Daly, N. L., Jennings, C. V., Anderson, M. A. and Craik, D. J. (2004) Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. Journal of Biological Chemistry, 279 45: 46858-46867. doi:10.1074/jbc.M407421200 83   82 Cited 77 times in Scopus77 3
Clark, Richard J., Akcan, Muharrem, Kaas, Quentin, Daly, Norelle L. and Craik, David J. (2012) Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon, 59 4: 446-455. doi:10.1016/j.toxicon.2010.12.003 127   19 Cited 19 times in Scopus19 0
Craik, David J., Clark, Richard J. and Daly, Norelle L. (2008) Cyclotides and conotoxins ultra-stable disulfide-rich peptides. Chimica Oggi -Chemistry Today, 26 4: 20-22. 56   1 Cited 1 times in Scopus1
Plan, MR, Goransson, U, Rosengren, KJ, Clark, RJ, Daly, NL, Evert, P, Chen, C, Cagauan, AG and Craik, DJ (2004). Cyclotides: Novel Peptidic Pesticides for Plant Protection. In: Journal of Peptide Science. , , (278-278). . 37   0
Clark, Richard J., Preza, Gloria C., Tan, Chia Chia, van Dijk, Johannes W. A., Fung, Eileen, Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2013) Design, synthesis and characterisation of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers: Peptide Science, 100 5: 519-526. doi:10.1002/bip.22350 50   6 0
Haugaard-Kedström, Linda M., Shabanpoor, Fazel, Hossain, Mohammed Akhter, Clark, Richard J., Ryan, Philip J., Craik, David J., Gundlach, Andrew L., Wade, John D., Bathgate, Ross A. D. and Rosengren, K. Johan (2011) Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. Journal of the American Chemical Society, 133 13: 4965-4974. doi:10.1021/ja110567j 99   25 Cited 27 times in Scopus27 0
Clark, RJ, Dempster, L, Daly, NL, Rosengren, KJ and Craik, DJ (2004). Design, Synthesis and Structural Studies of Cyclic Alpha-Conotoxins. In: Journal of Peptide Science. , , (269-269). . 35   0
Adams, D. J., Berecki, G., Clark, R. and Craik, D. J. (2013). Development of analgesic alpha-conotoxins for treatment of chronic pain. In: Special Issue: ACABS 2013: The Fourth Meeting of The Australia Chinese Association for Biomedical Sciences Inc. 4th Meeting of the Australia Chinese Association for Biomedical Sciences Inc (ACABS), Hangzhou Peoples R China, (4-4). 10-13 October 2013. doi:10.1111/1440-1681.12170 114   0 0
Berecki, Géza, McArthur, Jeffrey R., Cuny, Hartmut, Clark, Richard J. and Adams, David J. (2014) Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. Journal of General Physiology, 143 4: 465-479. doi:10.1085/jgp.201311104 23   3 Cited 3 times in Scopus3 70
Craik, David J., Anderson, Marilyn A., Barry, Daniel G., Clark, Richard J., Daly, Norelle L., Jennings, Cameron V. and Mulvenna, Jason P. (2001) Discovery and structures of the cyclotides: novel macrocyclic peptides from plants. Letters in Peptide Science, 8 3-5: 119-128. doi:10.1007/BF02446507 93   3 Cited 20 times in Scopus20 0
Gunasekera, Sunithi, Daly, Norelle L., Clark, Richard J. and Craik, David J. (2009) Dissecting the oxidative folding of circular cystine knot miniproteins. Antioxidants and Redox Signalling, 11 5: 971-980. doi:10.1089/ars.2008.2295 98 72 23 Cited 23 times in Scopus23 0
Korsinczky, M. L. J., Clark, R. J. and Craik, D. J. (2005) Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1. Biochemistry, 44 4: 1145-1153. doi:10.1021/bi048297r 75   25 Cited 21 times in Scopus21 0
Daly, N. L., Clark, R. J. and Craik, D. J. (2003) Disulfide folding pathways of cystine knot proteins: Tying the knot within the circular backbone of the cyclotides. The Journal of Biological Chemistry, 278 8: 6314-6322. doi:10.1074/jbc.M210492200 86   81 Cited 80 times in Scopus80 0
Daly, N. L., Clark, R. J., Goransson, U. and Craik, D. J. (2003) Diversity in the disulfide folding pathways of cystine knot peptides. Letters in Peptide Science, 10 5-6: 523-531. doi:10.1007/BF02442584 67   8 Cited 6 times in Scopus6 0
Garson, M. J., Clark, R., Webb, R. I., Field, K. L. and Charan, R. D. (1999). Ecological role of cytotoxic alkaloids: Haliclona n.sp., an unusual sponge/dinoflagellate association. In: Memoirs of the Queensland Museum. 5th International Sponge Conference, Brisbane, (205-213). 27 June - 4 July 1999. 92  
Halai, Reena, Callaghan, Brid, Daly, Norelle L., Clark, Richard J., Adams, David J. and Craik, David J. (2011) Effects of cyclization on stability, structure, and activity of alpha-conotoxin RgIA at the alpha 9 alpha 10 nicotinic acetylcholine receptor and GABA(B) receptor. Journal of Medicinal Chemistry, 54 19: 6984-6992. doi:10.1021/jm201060r 80   14 Cited 12 times in Scopus12 0
Clark, Richard J. and Craik, David J. (2012) Engineering cyclic peptide toxins. Methods in Enzymology, 503 57-74. doi:10.1016/B978-0-12-396962-0.00003-3 82   15 Cited 12 times in Scopus12 2
Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2011) Engineering of conotoxins for the treatment of pain. Current Pharmaceutical Design, 17 38: 4242-4253. 98 2 17 Cited 17 times in Scopus17
Chan, Lai Y., Gunasekera, Sunithi, Henriques, Sonia T., Worth, Natalie F., Le, Sarah-Jane, Clark, Richard J., Campbell, Julie H., Craik, David J. and Daly, Norelle L. (2011) Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds. Blood, 118 25: 6709-6717. doi:10.1182/blood-2011-06-359141 74   48 Cited 48 times in Scopus48 1
Chan, L. A., Gunasekera, S., Henriques, S. T., Worth, N. F., Le, S., Clark, R. J., Campbell, J. H., Craik, D. J. and Daly, N. L. (2012). Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds. In: 32nd European Peptide Symposium, Athens, Greece, (S40-S40). 2-7 September 2012. doi:10.1002/psc.2448 47   0 0
Clark, R. J., Fischer, H., Dempster, L., Daly, N. L., Rosengren, K. J., Nevin, S. T., Meunier, F. A., Adams, D. J. and Craik, D. J. (2005) Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the alpha-conotoxin MII. Proceedings of The National Academy of Sciences of The United States of America, 102 39: 13767-13772. doi:10.1073/pnas.0504613102 84   101 Cited 101 times in Scopus101 0
Gunasekera, Sunithi, Foley, Fiona M., Clark, Richard J., Sando, Lillian, Fabri, Louis J., Craik, David J. and Daly, Norelle L. (2008) Engineering stablized vascular endothelial growth factor-A antagonists: synthesis, structural characterization and bioactivity of grafted analogues of cyclotides. Journal of Medicinal Chemistry, 51 24: 7697-7704. doi:10.1021/jm800704e 66   81 Cited 79 times in Scopus79 0
Gruber, G. W., Cemazar, M., Clark, R., Horibe, T., Renda, R., Anderson, M. A. and Craik, D. J. (2007). Enzyme mechanism and function of a novel plant protein disulfide isomerase involved in the oxidative folding of cystine knot defence peptides. In: Susan Del Valle, Emanuel Escher and William D. Lubell, Biopolymers. 20th American-Peptide-Society Symposium, Montréal, Canada, (541-541). 26-30 Jun 2007. doi:10.1002/bip.20783 200   0 0
Akcan, Muharrem, Stroud, Mark R., Hansen, Stacey J., Clark, Richard J., Daly, Norelle L., Craik, David J. and Olson, James M. (2013) Erratum: Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy (Journal of Medicinal Chemistry (2011) 54 (782-787) DOI: 10.1021/jm101018r). Journal of Medicinal Chemistry, 56 23: 9807-9807. doi:10.1021/jm4016119 44   0 Cited 0 times in Scopus0 0
Burman, Robert, Svedlund, Erika, Felth, Jenny, Hassan, Saadia, Hermann, Anders, Clark, Richard James, Craik, David J., Bohlin, Lars, Claeson, Per, Goransson, Ulf and Gullbo, Joachim (2010). Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice. In: Proceedings of the 1st International Conference on Circular Proteins. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, (626-634). 18-21 October, 2009. doi:10.1002/bip.21408 91   13 Cited 14 times in Scopus14 0
Grishin, Anton A., Cuny, Hartmut, Hung, Andrew, Clark, Richard J., Brust, Andreas, Akondi, Kalyana, Alewood, Paul F., Craik, David J. and Adams, David J. (2013) Identifying key amino acid residues that affect alpha-conotoxin AuIB inhibition of alpha3beta4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288 48: 34428-34442. doi:10.1074/jbc.M113.512582 76 2 6 Cited 5 times in Scopus5 0
Millard, Emma L., Nevin, Simon T., Loughnan, Marion L., Nicke, Annette, Clark, Richard J., Alewood, Paul F., Lewis, Richard J., Adams, David J., Craik, David J. and Daly, Norelle L. (2009) Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues. Journal of Biological Chemistry, 284 8: 4944-4951. doi:10.1074/jbc.M804950200 97   17 Cited 18 times in Scopus18 0
Aboye, Teshome Leta, Clark, Richard J., Burman, Robert, Roig, Marta Bajona, Craik, David J. and Goransson, Ulf (2011) Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of Cyclotides. Antioxidants & Redox Signaling, 14 1: 77-86. doi:10.1089/ars.2010.3112 80 81 18 Cited 15 times in Scopus15 0
Malik, U., Silva, O. N., Fensterseifer, I. C. M., Chan, A., Clark, R. J., Franco, O. L., Daly, N. L. and Craik, D. J. (2015) In vivo efficacy of anuran rypsin inhibitory peptides against Staphylococcal Skin infection and the impact of peptide cyclization. Antimicrobial Agents and Chemotherapy, 59 4: 2113-2121. doi:10.1128/AAC.04324-14 8   Cited 0 times in Scopus0 0
Ireland, David C., Clark, Richard J., Daly, Norelle L. and Craik, David J. (2010) Isolation, sequencing, and structure - Activity relationships of cyclotides. Journal of Natural Products, 73 9: 1610-1622. doi:10.1021/np1000413 64   28 Cited 26 times in Scopus26 0
Daly, N. L., Clark, R. J., Plan, M. R. and Craik, D. J. (2006) Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochemical Journal, 393 Part 3: 619-626. doi:10.1042/BJ20051371 65   55 Cited 51 times in Scopus51 0
Barry, D. G., Daly, N. L., Clark, R. J., Sando, L. and Craik, D. J. (2003) Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry, 42 22: 6688-6695. doi:10.1021/bi027323n 60   74 Cited 71 times in Scopus71 0
Huang, Yen-Hua (黃彥華), Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C. and Craik, David J. (2010) Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. Journal of Biological Chemistry, 285 14: 10797-10805. doi:10.1074/jbc.M109.089854 71   38 Cited 38 times in Scopus38 0
Garson, M. J., Blunt, J. W., Clark, R., Degnan, B. M., Green, K. M., Munro, M. H., Simpson, J. and Skilleter, G. A. (2000). Marine ecology: The natural approach to finding bioactives. In: Australasian Biotechnological Association Conference. Australasian Biotechnological Association Conference, Brisbane, (). 2-6 July, 2000. 77  
Rosengren, K. J., Clark, R. J., Daly, N. L., Goransson, U., Jones, A. and Craik, D. J. (2003) Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Journal of the American Chemical Society, 125 41: 12464-12474. doi:10.1021/JA0367703 96   133 Cited 125 times in Scopus125 0
Halai, R., Clark, R., Nevin, S., Adams, D. and Craik, D. (2009). Mutational atudies on alpha-conotoxin VCL1. In: Abstracts of the 21st American Peptide Symposium. 21st American Peptide Symposium, Bloomington, Indiana, USA, (315-315). 7-12 June 2009. doi:10.1002/bip.21223 52   0 0

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