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Buscemi, Giacomo, Perego, Paola, Carenini, Nives, Nakanishi, Makoto, Chessa, Luciana, Chen, Junjie, Khanna, Kum Kum and Delia, Domenico (2004) Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene, 23 46: 7691-7700. doi:10.1038/sj.onc.1207986 94   59 Cited 60 times in Scopus60 3
Hinz, Michael, Stilmann, Michael, Arslan, Seda Çöl, Khanna, Kum Kum, Dittmar, Gunnar and Scheidereit, Claus (2010) A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Molecular Cell, 40 1: 63-74. doi:10.1016/j.molcel.2010.09.008 71 3 87 Cited 89 times in Scopus89 0
Liu, Chao, Srihari, Sriganesh, Le Cao, Kim-Anh, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A. and Khanna, Kum Kum (2014) A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Research, 42 10: 6106-6127. doi:10.1093/nar/gku284 57   6 Cited 5 times in Scopus5 5
Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007) A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 20: 15248-15257. doi:10.1074/jbc.M700246200 118   19 Cited 19 times in Scopus19 0
Simpson, Peter T., Vargas, Ana Christina, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2011) Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges. Human Pathology, 42 2: 153-165. doi:10.1016/j.humpath.2010.07.008 79 1 4 Cited 4 times in Scopus4 0
Lakhani, Sunil R., Khanna, Kum K. and Chenevix-Trench, Georgia (2010) Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?. Breast Cancer Research, 12 2: 104-1-104-2. doi:10.1186/bcr2483 73   3 Cited 3 times in Scopus3 0
Gatei, M, Shkedy, D, Khanna, KK, Uziel, T, Shiloh, Y, Pandita, TK, Lavin, MF and Rotman, G (2001) Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene, 20 3: 289-294. doi:10.1038/sj.onc.1204111 66   44 Cited 51 times in Scopus51 0
Gatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T.K., Lavin, M. F. and Rotman, G. (2001) Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies. Journal of Biological Chemistry, 276 20: 17276-17280. doi:10.1074/jbc.M011681200 198   128 Cited 131 times in Scopus131 3
Gatei, Magtouf, Zhou, Bin-Bing, Hobson, Karen, Scott, Shaun, Young, David and Khanna, Kum Kum (2001) Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies. Journal of Biological Chemistry, 276 20: 17276-17280. doi:10.1074/jbc.M011681200 72   128 Cited 131 times in Scopus131 3
Khanna, Kum Kum and Chenevix-Trench, Georgia (2004) ATM and Genome Maintenance: Defining Its Role in Breast Cancer Susceptibility. Journal of Mammary Gland Biology and Neoplasia, 9 3: 247-262. doi:10.1023/B:JOMG.0000048772.92326.a1 36   21 Cited 20 times in Scopus20 0
Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P. and Khanna, K. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genetics, 25 1: 115-119. 66   358
Bhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011) ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 18: 2977-3006. doi:10.1007/s00018-011-0683-9 63   43 Cited 43 times in Scopus43 0
Lavin, M. F. and Khanna, K. K. (1999) ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasia. International Journal of Radiation Biology, 75 10: 1201-1214. 45   66
Goodarzi, Aaron A, Jonnalagadda, Jyoti C., Douglas, Pauline, Young, David, Ye, Ruiqiong, Moorhead, Greg B. G., Lees-Miller, Susan P. and Khanna, Kum Kum (2004) Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. The EMBO Journal, 23 22: 4451-4461. doi:10.1038/sj.emboj.7600455 48   139 Cited 149 times in Scopus149 1
Jung, Cha-Gyun, Uhm, Kyung-Ok, Miura, Yutaka, Hosono, Takashi, Horike, Hirofumi, Khanna, Kum Kum, Kim, Mi-Jeong and Michikawa, Makoto (2011) Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons. Molecular Neurodegeneration, 6 47: 1-14. doi:10.1186/1750-1326-6-47 46   9 Cited 6 times in Scopus6 0
Fabbro, Megan, Savage, Kienan, Hobson, Karen, Deans, Andrew J., Powell, Simon N., McArthur, Grant A. and Khanna, Kum Kum (2004) BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. The Journal of Biological Chemistry., 279 30: 31251-31258. doi:10.1074/jbc.M405372200 60   72 Cited 78 times in Scopus78 3
Kang, Hyo Jin, Kim, Hee Jeong, Kim, Sang Keun, Barouki, Robert, Cho, Chi-Heum, Khanna, Kum Kum, Rosen, Eliot M. and Bae, Insoo (2006) BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. The Journal of Biological Chemistry., 281 21: 14654-14662. doi:10.1074/jbc.M601613200 87   31 Cited 37 times in Scopus37 0
AL-Ejeh, Fares, Smart, Chanel E., Morrison, Brian J., Chenevix-Trench, Georgia, Lopez, J. Alejandro, Lakhani, Sunil R., Brown, Michael P. and Khanna, Kum Kum (2011) Breast cancer stem cells: Treatment resistance and therapeutic opportunities. Carcinogenesis, 32 5: 650-658. doi:10.1093/carcin/bgr028 121   36 Cited 40 times in Scopus40 0
Zhou, B., Chaturvedi, P.S., Spring, K., Scott, S. P., Johanson, R. A., Mishra, R.G., Mattern, M. R., Winkler, J. D. and Khanna, K. K. (2000) Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. Journal of Biological Chemistry, 275 14: 10342-10348. doi:10.1074/jbc.275.14.10342 127   230 Cited 230 times in Scopus230 9
Khanna, Kum Kum (2000) Cancer risk and the ATM gene: a continuing debate. Journal of the National Cancer Institute, 92 10: 795-802. doi:10.1093/jnci/92.10.795 39   118 0
Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009) Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 14: 2198-2210. doi:10.4161/cc.8.14.8947 67   55 Cited 58 times in Scopus58 3
Jeffery, J. M., Urquhart, A. J., Subramaniam, V. N., Parton, R.G. and Khanna, K.K. (2010) Centrobin regulates the assembly of functional mitotic spindles. Oncogene, 29 18: 2649-2658. doi:10.1038/onc.2010.37 84   16 Cited 15 times in Scopus15 0
Armando van der Horst, Jacinta Simmons and Kum Kum Khanna (2009) Cep55 stabilization is required for normal execution of cytokinesis. Cell Cycle, 8 22: 3742-3749. doi:10.4161/cc.8.22.10047 46   7 Cited 8 times in Scopus8 3
Waddell, Nic, Jonnalagadda, Jyoti, Marsh, Anna, Grist, Scott, Jenkins, Mark, Hobson, Karen, Taylor, Malcolm, Lindeman, Geoff J., Tavtigian, Sean V., Suthers, Graeme, Goldgar, David, Oefner, Peter J., kConFab Investigators, Taylor, Darrin, Grimmond, Sean, Khanna, Kum Kum and Chenevix-Trench, Georgia (2006) Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling. Genes Chromosomes and Cancer, 45 12: 1169-1181. doi:10.1002/gcc.20381 111   7 Cited 5 times in Scopus5 0
Bruno, Tiziana, De Nicola, Francesca, Iezzi, Simona, Lecis, Daniele, D'Angelo, Carmen, Di Padova, Monica, Corbi, Nicoletta, Dimiziani, Leopoldo, Zannini, Laura, Jekimovs, Christian, Scarsella, Marco, Porrello, Alessandro, Chersi, Alberto, Crescenzi, Marco, Leonetti, Carlo, Khanna, Kum Kum, Soddu, Silvia, Floridi, Aristide, Passananti, Claudio, Domenico Delia and Fanciulli, Maurizio (2006) Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell, 10 6: 473-486. doi:10.1016/j.ccr.2006.10.012 131   47 Cited 58 times in Scopus58 0
Chen, P., Gatei, M., O'Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K. and Lavin, M. F. (1999) CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasia. Oncogene, 18 1: 249-256. doi:10.1038/sj.onc.1202257 48   38 Cited 42 times in Scopus42 0
Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, S., Mizutani, S., Khanna, K., Chen, P., Concannon, P., Chessa, L. and Delia, D. (2001) Chk2 activation dependence on Nbs1 after DNA damage. Molecular & Cellular Biology, 21 15: 5214-5222. doi:10.1128/MCB.21.15.5214-5222.2001 41   156 Cited 162 times in Scopus162 3
Caterina Di Cosmo, Neil McLellan, Xiao-Hui Liao, Kum Kum Khanna, Roy E. Weiss, Laura Papp and Samuel Refetoff (2009) Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X). Journal of Clinical Endocrinology and Metabolism, 94 10: 4003-4009. doi:10.1210/jc.2009-0686 61   31 Cited 26 times in Scopus26 1
Srihari, Sriganesh, Madhamshettiwar, Piyush B., Song, Sarah, Liu, Chao, Simpson, Peter T., Khanna, Kumkum and Ragan, Mark A. (2014) Complex-based analysis of dysregulated cellular processes in cancer. BMC Systems Biology, 8 Supplement 4: . doi:10.1186/1752-0509-8-S4-S1 44   1 1
Deans, Andrew J., Khanna, Kum Kum, McNees, Carolyn J., Mercurio, Ciro, Heierhorst, Jörg and McArthur, Grant A. (2006) Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. Cancer Research, 66 16: 8219-8226. doi:10.1158/0008-5472.CAN-05-3945 52   58 Cited 58 times in Scopus58 1
Khanna, K.K. and Tibbetts, R. (2003) DNA damage response in David N. Cooper (eds.) Nature encyclopedia of the human genome. London, UK: Nature Publishing Group 27  
Jackson, S.P. and Khanna, K. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics, 27 3: 247-254. doi:10.1038/85798 383   1186 Cited 1255 times in Scopus1255 3
Flanagan, James M., Cocciardi, Sibylle, Waddell, Nic, Johnstone, Cameron N., Marsh, Anna, Henderson, Stephen, Simpson, Peter, da Silva, Leonard, kConFab Investigators, Khanna, Kumkum, Lakhani, Sunil, Boshoff, Chris, Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010) DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. American Journal of Human Genetics, 86 3: 420-433. doi:10.1016/j.ajhg.2010.02.008 150 7 40 Cited 47 times in Scopus47 0
Henderson, Michelle J., Munoz, Marcia A, Saunders, Darren N., Clancy, Jennifer L., Russell, Amanda J., Williams, Brandi, Pappin, Darryl, Khanna, Kum Kum, Jackson, Stephen P., Sutherland, Robert L. and Watts, Colin K. W. (2006) EDD mediates DNA damage-induced activation of CHK2. Journal of Biological Chemistry, 281 52: 39990-40000. doi:10.1074/jbc.M602818200 46   27 Cited 27 times in Scopus27 0
Gueven, Nuri, Keatings, Katherine E., Chen, Philip, Fukao, Toshiyuki, Khanna, Kum Kum, Watters, Dianne, Rodemann, Peter H. and Lavin, Martin F. (2001) EGF sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. The Journal of Biological Chemistry, 276 12: 8884-8891. doi:10.1074/jbc.M006190200 52   37 Cited 0 times in Scopus0 0
Shi, Wei, Bain, Amanda L., Schwer, Bjoern, Al-Ejeh, Fares, Smith, Corey, Wong, Lee, Chai, Hua, Miranda, Mariska S., Ho, Uda, Kawaguchi, Makoto, Miura, Yutaka, Finnie, John W., Wall, Meaghan, Heierhorst, Jorg, Wicking, Carol, Spring, Kevin J., Alt, Frederick W. and Khanna, Kum Kum (2013) Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genetics, 9 2: e1003298.1-e1003298.19. doi:10.1371/journal.pgen.1003298 46   9 Cited 8 times in Scopus8 1
Pylkas, K, Tommiska, J, Syrjakoski, K, Kere, J, Gatei, M, Waddell, N, Allinen, M, Karppinen, SM, Rapakko, K, Kaariainen, H, Aittomaki, K, Blomqvist, C, Mustonen, A, Holli, K, Khanna, KK, Kallioniemi, OP, Nevanlinna, H and Winqvist, R (2007) Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer. Carcinogenesis, 28 5: 1040-1045. doi:10.1093/carcin/bgl237 55   10 Cited 9 times in Scopus9 0
Brown, M. A., Nicolai, H., Howe, K., Katagiri, T., Lalani, E., Simpson, K. J., Manning, N. W., Deans, A., Chen, P., Khanna, K. K., Wati, M. R., Griffiths, B. L., Xu, C. F., Stamp, G. W. H. and Solomon, E. (2002) Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice. Transgenic Research, 11 5: 467-478. doi:10.1023/A:1020348025139 57   24 Cited 23 times in Scopus23 0
Imyanitov, Evgeny N., Birrell, Geoff W., Filippovich, Igor, Sorokina, Natasha, Arnold, Jeremy, Mould, Michelle A., Wright, Kim, Walsh, Michael, Mok, Samuel C ., Lavin, Martin F., Chenevix-Trench, Georgia and Khanna, Kum Kum (1999) Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target. Oncogene, 18 32: 4640-4642. doi:10.1038/sj.onc.1202863 45   35 Cited 30 times in Scopus30 0
Papp, Laura Vanda, Lu, Jun, Holmgren, Arne and Khanna, Kum Kum (2007) From selenium to selenoproteins: Synthesis, identity, and their role in human health. Antioxidants & Redox Signaling, 9 7: 775-806. doi:10.1089/ars.2007.1528 72   411 Cited 438 times in Scopus438 14
Dicker, A., Serewko, M. S., Dahler, A. L., Khanna, K. K., Kaur, P., Li, A., Strutton, G. and Saunders, N. A. (2000) Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1). Experimental Cell Research, 258 2: 352-360. doi:10.1006/excr.2000.4944 90   15 Cited 16 times in Scopus16 0
Al-Ejeh, Fares, Pajic, Marina, Shi, Wei, Kalimutho, Murugan, Miranda, Mariska, Nagrial, Adnan M., Chou, Angela, Biankin, Andrew V., Grimmond, Sean M., Brown, Michael P. and Khanna, Kum Kum (2014) Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma. Clinical Cancer Research, 20 12: 3187-3197. doi:10.1158/1078-0432.CCR-14-0048 35   1 Cited 2 times in Scopus2 3
Al-Ejeh, F., Kumar, R., Wiegmans, A., Lakhani, S.R., Brown, M.P. and Khanna, K.K. (2010) Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene, 29 46: 6085-6098. doi:10.1038/onc.2010.407 79   44 Cited 51 times in Scopus51 0
Da Silva, Leonard, Simpson, Peter T., Smart, Chanek E., Cocciardi, Sibylle, Waddell, Nic, Lane, Annette, Morrison, Brian J., Vargas, Ana Cristina, Healey, Sue, Beesley, Jonathan, Pakkiri, Pria, Parry, Suzanne, Kurniawan, Nyoman, Reid, Lynne, Keith, Patricia, Faria, Paulo, Pereira, Emilio, Skalova, Alena, Bilous, Michael, Balleine, Rosemary L., Do, Hongdo, Dobrovic, Alexander, Fox, Stephen, Franco, Marcello, Reynolds, Brent, Khanna, Kum Kum, Cummings, Margaret, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2010) HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast Cancer Research, 12 4: R46-1-R46-11. doi:10.1186/bcr2603 119   26 Cited 30 times in Scopus30 0
Jung, Cha-Gyun, Kim, Hye-Jung, Kawaguchi, Makoto, Khanna, Kum Kum, Hida, Hideki, Asai, Kiyofumi, Nishino, Hitoo and Miura, Yutaka (2005) Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation. Development, 132 23: 5137-5145. doi:10.1242/dev.02098 44   35 Cited 34 times in Scopus34 0
Yongjiang Li, Emma Bolderson, Rakesh Kumar, Parameswary A. Muniandy, Yutong Xue, Derek J. Richard, Michael Seidman, Tej K. Pandita, Kum Kum Khanna and Weidong Wang (2009) hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response. Journal of Biological Chemistry, 284 35: 23525-23531.. doi:10.1074/jbc.C109.039586 91   41 Cited 44 times in Scopus44 0
Richard, Derek J., Cubeddu, Liza, Urquhart, Aaron J., Bain, Amanda, Bolderson, Emma, Menon, Dinoop, White, Malcolm F. and Khanna, Kum Kum (2011) hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Research, 39 9: 3643-3651. doi:10.1093/nar/gkq1340 44 1 16 Cited 20 times in Scopus20 0
Richard, Derek J., Savage, Kienan, Bolderson, Emma, Cubeddu, Liza, So, Sairei, Ghita, Mihaela, Chen, David J., White, Malcolm F., Richard, Kerry, Prise, Kevin M., Schettino, Giuseppe and Khanna, Kum Kum (2011) hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Research, 39 5: 1692-1702. doi:10.1093/nar/gkq1098 50   16 Cited 21 times in Scopus21 0
Young, David B., Jonnalagadda, Jyoti, Gatei, Magtouf, Jans, David A., Meyn, Stephen and Khanna, Kum Kum (2005) Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. The Journal of Biological Chemistry, 280 30: 27587-27594. doi:10.1074/jbc.M411689200 52   29 Cited 30 times in Scopus30 0
Jeffrey R. Skaar, Derek J. Richard, Anita Saraf, Alfredo Toschi, Emma Bolderson, Laurence Florens, Michael P. Washburn, Kum Kum Khanna and Michele Pagano (2009) INTS3 controls the hSSB1-mediated DNA damage response. The Journal of Cell Biology, 187 1: 25-32. doi:10.1083/jcb.200907026 70   29 Cited 32 times in Scopus32 0

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