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Ruitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. In: Journal of Neurotrauma. 11th Symposium of the International-Neurotrauma-Society, Budapest Hungary, (A26-A26). Mar 19-23, 2014. 69   0
Woodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 9: 2476-2485. doi:10.1002/art.10449 98   75 Cited 73 times in Scopus73 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005) A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 5: 883-892. doi:10.1016/j.intimp.2005.01.003 89   21 Cited 26 times in Scopus26 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003) A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 10: 5514-5520. 90   72 Cited 72 times in Scopus72
Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013) A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 10: 1557-1568. doi:10.1111/pme.12157 71   10 Cited 12 times in Scopus12 4
Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014) Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 12: 3278-3284. doi:10.1002/stem.1801 23   0 Cited 0 times in Scopus0 1
Woodruff, Trent M. (2014). C3a and C5a homeostasis in health and disease. In: Molecular Immunology. 25th International Complement Workshop, Rio de Janeiro Brazil, (247-248). Sep 14-18, 2014. 9   0
Denny, Kerina J., Coulthard, Liam G., Jeanes, Angela, Lisgo, Steven, Simmons, David G., Callaway, Leonie K., Wlodarczyk, Bogdan, Finnell, Richard H., Woodruff, Trent M. and Taylor, Stephen M. (2013) C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. Journal of Immunology, 190 7: 3493-3499. doi:10.4049/jimmunol.1203072 50   3 Cited 4 times in Scopus4 0
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M. and Woodruff, Trent M. (2013) C5L2: a controversial receptor of complement anaphylatoxin, C5a. FASEB Journal, 27 3: 855-864. doi:10.1096/fj.12-220509 61   26 Cited 24 times in Scopus24 1
Higginbottom, Adrian, Cain, Stuart A., Woodruff, Trent M., Proctor, Lavinia M., Madala, Praveen K., Tyndall, Joel D. A., Taylor, Stephen M., Fairlie, David P. and Monk, Peter N. (2005) Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280 18: 17831-17840. doi:10.1074/jbc.M410797200 102   24 Cited 22 times in Scopus22 0
Brennan, Faith H., Anderson, Aileen J., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012) Complement activation in the injured central nervous system: Another dual-edged sword?. Journal of Neuroinflammation, 9 1: . doi:10.1186/1742-2094-9-137 60   27 Cited 25 times in Scopus25 2
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011) Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 7: 2447-2455. doi:10.1096/fj.10-174284 67   27 Cited 27 times in Scopus27 0
Lappas, Martha, Woodruff, Trent M., Taylor, Stephen M. and Permezel, Michael (2012) Complement C5a regulates prolabor mediators in human placenta. Biology of Reproduction, 86 6: 190.1-190.9. doi:10.1095/biolreprod.111.098475 31   3 Cited 6 times in Scopus6 1
Manthey, Helga D., Woodruff, Trent M., Taylor, Stephen M. and Monk, Peter N. (2009) Complement component 5a (C5a). International Journal of Biochemistry and Cell Biology, 41 11: 2114-2117. doi:10.1016/j.biocel.2009.04.005 91   50 Cited 49 times in Scopus49 3
de Vries, Margreet R., Wezel, Anouk, Schepers, Abbey, van Santbrink, Peter J., Woodruff, Trent M., Niessen, Hans W. M., Hamming, Jaap F., Kuiper, Johan, Bot, Ilze and Quax, Paul H. A. (2013) Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. Cardiovascular Research, 97 2: 311-320. doi:10.1093/cvr/cvs312 32   9 Cited 10 times in Scopus10 0
Proctor, Lavinia M., Moore, Tyson A., Monk, Peter N., Sanderson, Sam D., Taylor, Stephen M. and Woodruff, Trent M. (2009) Complement factors C3a and C5a have distinct hemodynamic effects in the rat. International Immunopharmacology, 9 6: 800-806. doi:10.1016/j.intimp.2009.03.002 81   8 Cited 8 times in Scopus8 0
Proctor, Lavinia M., Strachan, Anna J., Woodruff, Trent M., Mahadevan, Indumathy B., Williams, H. Ming, Shiels, Ian A. and Taylor, Stephen M. (2006) Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. International Immunopharmacology, 6 8: 1224-1232. doi:10.1016/j.intimp.2006.03.002 343   17 Cited 19 times in Scopus19 0
Denny, Kerina J., Woodruff, Trent M., Taylor, Stephen M. and Callaway, Leonie K. (2013) Complement in pregnancy: a delicate balance. American Journal of Reproductive Immunology, 69 1: 3-11. doi:10.1111/aji.12000 52   9 Cited 11 times in Scopus11 0
Arumugam, Thiruma V., Magnus, Tim, Woodruff, Trent M., Proctor, Lavinia M., Shiels, Ian A., Taylor, Stephen M., A. H. Wu and J. Delanghe (2006) Complement mediators in ischemia-reperfusion injury. Clinica Chimica Acta, 374 1-2: 33-45. doi:10.1016/j.cca.2006.06.010 67   60 Cited 63 times in Scopus63 0
Brennan, Faith H., Blomster, Linda V., Costantini, Alexander M., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia. In: Proceedings of the 11th International Congress of Neuroimmunology (ISNI). 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, (89-90). 4-8 November 2012. 69   0
Peng, Qi, Li, Ke, Wang, Naiyin, Li, Qijun, Asgari, Elham, Lu, Bao, Woodruff, Trent M., Sacks, Steven H. and Zhou, Wuding (2009) Dendritic cell function in allostimulation is modulated by C5aR signaling. Journal of Immunology, 183 10: 6058-6068. doi:10.4049/jimmunol.0804186 54   52 Cited 50 times in Scopus50 0
Bellows-Peterson, Meghan L., Fung, Ho Ki, Floudas, Christodoulos A., Kieslich, Chris A., Zhang, Li, Morikis, Dimitrios, Wareham, Kathryn J., Monk, Peter N., Hawksworth, Owen A. and Woodruff, Trent M. (2012) De novo peptide design with C3a receptor agonist and antagonist activities: Theoretical predictions and experimental validation. Journal of Medicinal Chemistry, 55 9: 4159-4168. doi:10.1021/jm201609k 56   19 Cited 20 times in Scopus20 0
Monkl, Peter N., Bellows-Peterson, Meghan L., Smadbeck, James, Floudas, Christodoulos A., Kieslich, Christopher A., Morikis, Dimitrios and Woodruff, Trent M. (2012). De novo protein design of agonists and antagonists of C5a receptors. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1162-1163). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.097 43   1 0
Halai, Reena, Bellows-Peterson, Meghan L., Branchett, Will, Smadbeck, James, Kieslich, Chris A., Croker, Daniel E., Cooper, Matthew A., Morikis, Dimitrios, Woodruff, Trent M., Floudas, Christodoulos A. and Monk, Peter N. (2014) Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. European Journal of Pharmacology, 745 176-181. doi:10.1016/j.ejphar.2014.10.041 14   0 Cited 0 times in Scopus0 1
Lee, John D., Kamaruzaman, Nur A., Fung, Jenny N. T., Taylor, Stephen M., Turner, Bradley J., Atkin, Julie D., Woodruff, Trent M. and Noakes, Peter G. (2013) Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 10 . doi:10.1186/1742-2094-10-119 47   5 Cited 4 times in Scopus4 3
Denny, Kerina J., Coulthard, Liam G., Finnell, Richard H., Callaway, Leonie K., Taylor, Stephen M. and Woodruff, Trent M. (2013) Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. Journal of Reproductive Immunology, 97 2: 211-216. doi:10.1016/j.jri.2012.11.006 41   5 Cited 5 times in Scopus5 0
Coulthard, Mark G., Morgan, Michael, Woodruff, Trent M., Arumugam, Thiruma V., Taylor, Stephen M., Carpenter, Todd C., Martin Lackmann, and Boyd, Andrew W. (2012) Eph/Ephrin signaling in injury and inflammation. American Journal of Pathology, 181 5: 1493-1503. doi:10.1016/j.ajpath.2012.06.043 68   13 Cited 16 times in Scopus16 0
Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014) Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126 13-27. doi:10.1016/j.pbb.2014.09.003 32   0 Cited 0 times in Scopus0 0
Thundyil, John, Tang, Sung-Chun, Okun, Eitan, Shah, Kausik, Karamyan, Vardan T., Li , Yu-I, Woodruff, Trent M., Taylor, Stephen M., Jo, Dong-Gyu, Mattson, Mark P and Arumugam, Thiruma V. (2010) Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Experimental and Translational Stroke Medicine, 2 1: 15-1-15-8. doi:10.1186/2040-7378-2-15 55   Cited 17 times in Scopus17 0
Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2012). Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1169-1169). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.116 44   0 0
Pavlovski, Dale, Thundyil, John, Monk, Peter N., Wetsel, Rick A., Taylor, Stephen M. and Woodruff, Trent M. (2012) Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. The FASEB Journal, 26 9: 3680-3690. doi:10.1096/fj.11-202382 80   14 Cited 19 times in Scopus19 0
Dekker Nitert, Marloes, Barrett, Helen L., Kubala, Marta H., Scholz Romero, Katherin, Denny, Kerina J., Woodruff, Trent M., David McIntyre, H. David and Callaway, Leonie K. (2014) Increased placental expression of fibroblast growth factor 21 in gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 99 4: E591.1-E591.8. doi:10.1210/jc.2013-2581 28   Cited 0 times in Scopus0 2
Woodruff, Trent M., Nandakumar, Kutty S. and Tedesco, Francesco (2011) Inhibiting the C5-C5a receptor axis. Molecular Immunology, 48 14: 1631-1642. doi:10.1016/j.molimm.2011.04.014 102   70 Cited 75 times in Scopus75 0
Iyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay (2011) Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 58 5: 479-486. doi:10.1097/FJC.0b013e31822a7a09 37   11 Cited 11 times in Scopus11 1
Lee, John D., Lee, Jia Y., Taylor, Stephen M., Noakes, Peter G. and Woodruff, Trent M. (2012). Innate immunity in ALS. In Martin H. Maurer (Ed.), Amyotrophic lateral sclerosis (pp. 393-412) Croatia: InTech - Open Access Publisher. 108 3
Tamamis, Phanourios, Kieslich, Chris A., Nikiforovich, Gregory V., Woodruff, Trent M., Morikis, Dimitrios and Archontis, Georgios (2014) Insights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and docking. Bmc Biophysics, 7 . doi:10.1186/2046-1682-7-5 13   0 2
Ager, Rahasson R., Fonseca, Maira I., Chu, Shu-Hui, Sanderson, Sam D., Taylor, Stephen M., Woodruff, Trent M. and Tenner, Andrea J. (2010) Microglial C5aR (CD88) expression correlates with amyloid-β deposition in murine models of Alzheimer's disease. Journal of Neurochemistry, 113 2: 389-401. doi:10.1111/j.1471-4159.2010.06595.x 47   20 Cited 25 times in Scopus25 0
Denny, Kerina J., Jeanes, Angela, Fathe, Kristin, Finnell, Richard H., Taylor, Stephen M. and Woodruff, Trent M. (2013) Neural tube defects, folate, and immune modulation. Birth Defects Research Part A - Clinical and Molecular Teratology, 97 9: 602-609. doi:10.1002/bdra.23177 17   2 Cited 2 times in Scopus2 0
Woodruff, Trent M., Thundyil, John, Tang, Sung Chun, Sobey, Christopher G., Taylor, Stephen M. and Arumugam, Thiruma V. (2011) Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Molecular Neurodegeneration, 6 1: 1-19. doi:10.1186/1750-1326-6-11 119   54 Cited 70 times in Scopus70 0
Morgan, Michael, Bulmer, Andrew C., Woodruff, Trent M., Proctor, Lavinia M., Williams, Hua M., Stocks, Shelli Z., Pollitt, Sandra, Taylor, Stephen M. and Shiels, Ian A (2008) Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration. European Journal of Pharmaceutical Sciences, 33 4-5: 390-398. doi:10.1016/j.ejps.2008.01.009 85   5 Cited 6 times in Scopus6 0
Lathia, Justin D., Chigurupati, Srinivasulu, Thundyil, John, Selvaraj, Pradeep K., Mughal, Mohamed R., Woodruff, Trent M., Chan, Sic L., Karamyan, Vardan T., Mattson, Mark P. and Arumugam, Thiruma V. (2009) Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke. Experimental Neurology, 221 1: 107-114. doi:10.1016/j.expneurol.2009.10.007 57   10 Cited 11 times in Scopus11 0
Barrett, Helen L., Kubala, Marta H., Scholz Romero, Katherin, Denny, Kerina J., Woodruff, Trent M., McIntyre, H. David, Callaway, Leonie K. and Nitert, Marloes Dekker (2014) Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM). PLoS One, 9 8: e104826.1-e104826.8. doi:10.1371/journal.pone.0104826 25   0 Cited 0 times in Scopus0 1
March, Darren R., Proctor, Lavinia M., Stoermer, Martin J., Sbaglia, Robert, Abbenante, Giovanni, Reid, Robert C., Woodruff, Trent M., Wadi, Khemar, Paczkowski, Natalii, Tyndall, Joel D. A., Taylor, Stephen M. and Fairlie, David P. (2004) Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activity. Molecular Pharmacology, 65 4: 868-879. doi:10.1124/mol.65.4.868 79   41 Cited 37 times in Scopus37 0
Arumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004) Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 6: 934-941. doi:10.1016/j.jhep.2004.02.017 94   46 Cited 51 times in Scopus51 0
Arumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine. Journal of Surgical Research, 103 2: 260-267. doi:10.1006/jsre.2002.6369 67   70 Cited 73 times in Scopus73 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004) Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 1: 81-90. doi:10.1016/j.jss.2003.04.001 130   49 Cited 50 times in Scopus50 0
Beck, Kevin D., Nguyen, Hal X., Galvan, Manuel D., Salazar, Desireé L., Woodruff, Trent M. and Anderson, Aileen J. (2010) Quantitative analysis of cellular inflammation after traumatic spinal cord injury: Evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain, 133 2: 433-447. doi:10.1093/brain/awp322 79   106 Cited 110 times in Scopus110 3
Proctor, Lavinia M., Woodruff, Trent M. and Taylor, Stephen M. (2006) Recent developments in C5/C5a inhibitors. Expert Opinion On Therapeutic Patents, 16 4: 445-458. doi:10.1517/13543776.16.4.445 132   9 Cited 10 times in Scopus10 0
Woodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014) Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 1: E3-E4. doi:10.1073/pnas.1321248111 99   2 Cited 2 times in Scopus2 2
Woodruff, Trent M., Strachan, Anna J., Sanderson, Sam D., Monk, Peter N., Wong, Allan K., Fairlie, David P. and Taylor, Stephen M. (2001) Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes. Inflammation, 25 3: 171-177. doi:10.1023/A:1011036414353 55   34 Cited 34 times in Scopus34 0

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