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Michael Morgan, Taylor, Stephen M. and Shiels, I (2007) A C5a receptor antagonist provides greater protection than an NSAID in a skin pouch model of sodium urate induced inflammation. Molecular Immunology, 44 1-3: 217-217. doi:10.1016/j.molimm.2006.07.164 248   0 0
Reid, Robert C., Abbenante, Giovanni, Taylor, Stephen M. and Fairlie, David P. (2003) A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. Journal of Organic Chemistry, 68 11: 4464-4471. doi:10.1021/jo034228r 238   33 Cited 33 times in Scopus33 0
Ruitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. In: Journal of Neurotrauma. 11th Symposium of the International-Neurotrauma-Society, Budapest Hungary, (A26-A26). Mar 19-23, 2014. 75   0
Woodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 9: 2476-2485. doi:10.1002/art.10449 102   75 Cited 74 times in Scopus74 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005) A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 5: 883-892. doi:10.1016/j.intimp.2005.01.003 90   21 Cited 26 times in Scopus26 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003) A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 10: 5514-5520. 97   75 Cited 75 times in Scopus75
Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014) Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 12: 3278-3284. doi:10.1002/stem.1801 32   0 Cited 1 times in Scopus1 1
Denny, Kerina J., Coulthard, Liam G., Jeanes, Angela, Lisgo, Steven, Simmons, David G., Callaway, Leonie K., Wlodarczyk, Bogdan, Finnell, Richard H., Woodruff, Trent M. and Taylor, Stephen M. (2013) C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. Journal of Immunology, 190 7: 3493-3499. doi:10.4049/jimmunol.1203072 53   3 Cited 4 times in Scopus4 0
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M. and Woodruff, Trent M. (2013) C5L2: a controversial receptor of complement anaphylatoxin, C5a. FASEB Journal, 27 3: 855-864. doi:10.1096/fj.12-220509 66   28 Cited 28 times in Scopus28 1
Higginbottom, Adrian, Cain, Stuart A., Woodruff, Trent M., Proctor, Lavinia M., Madala, Praveen K., Tyndall, Joel D. A., Taylor, Stephen M., Fairlie, David P. and Monk, Peter N. (2005) Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280 18: 17831-17840. doi:10.1074/jbc.M410797200 111   24 Cited 23 times in Scopus23 0
Proctor, Lavinia M., Arumugam, Thiruma V., Shiels, Ian, Reid, Robert C., Fairlie, David P. and Taylor, Stephen M . (2004) Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology, 142 4: 756-764. doi:10.1038/sj.bjp.0705819 84   45 Cited 52 times in Scopus52 0
Coulthard, Liam G., Costello, Jaclyn, Robinson, Brent, Shiels, Ian A., Taylor, Stephen M. and Woodruff, Ttrent M. (2011) Comparative efficacy of a secretory phospholipase A(2) inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis. Arthritis Research & Therapy, 13 2: R42-1-R42-10. doi:10.1186/ar3278 79   8 Cited 9 times in Scopus9 0
Arumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003) Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 1: 71-80. doi:10.1038/sj.bjp.0705402 95   31 Cited 32 times in Scopus32 0
Brennan, Faith H., Anderson, Aileen J., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012) Complement activation in the injured central nervous system: Another dual-edged sword?. Journal of Neuroinflammation, 9 1: . doi:10.1186/1742-2094-9-137 64   28 Cited 26 times in Scopus26 2
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011) Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 7: 2447-2455. doi:10.1096/fj.10-174284 68   28 Cited 29 times in Scopus29 0
Harkin, Denis W., Romaschin, Alex, Taylor, Stephen M., Rubin, Barry B. and Lindsay, Thomas F. (2004) Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm. Journal of Vascular Surgery, 39 1: 196-206. doi:10.1016/j.jvs.2003.07.001 57   30 Cited 36 times in Scopus36 0
Lappas, Martha, Woodruff, Trent M., Taylor, Stephen M. and Permezel, Michael (2012) Complement C5a regulates prolabor mediators in human placenta. Biology of Reproduction, 86 6: 190.1-190.9. doi:10.1095/biolreprod.111.098475 32   4 Cited 6 times in Scopus6 1
Manthey, Helga D., Woodruff, Trent M., Taylor, Stephen M. and Monk, Peter N. (2009) Complement component 5a (C5a). International Journal of Biochemistry and Cell Biology, 41 11: 2114-2117. doi:10.1016/j.biocel.2009.04.005 95   50 Cited 52 times in Scopus52 3
Proctor, Lavinia M., Moore, Tyson A., Monk, Peter N., Sanderson, Sam D., Taylor, Stephen M. and Woodruff, Trent M. (2009) Complement factors C3a and C5a have distinct hemodynamic effects in the rat. International Immunopharmacology, 9 6: 800-806. doi:10.1016/j.intimp.2009.03.002 88   9 Cited 10 times in Scopus10 0
Proctor, Lavinia M., Strachan, Anna J., Woodruff, Trent M., Mahadevan, Indumathy B., Williams, H. Ming, Shiels, Ian A. and Taylor, Stephen M. (2006) Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. International Immunopharmacology, 6 8: 1224-1232. doi:10.1016/j.intimp.2006.03.002 343   19 Cited 23 times in Scopus23 0
Denny, Kerina J., Woodruff, Trent M., Taylor, Stephen M. and Callaway, Leonie K. (2013) Complement in pregnancy: a delicate balance. American Journal of Reproductive Immunology, 69 1: 3-11. doi:10.1111/aji.12000 57   10 Cited 12 times in Scopus12 0
Arumugam, Thiruma V., Magnus, Tim, Woodruff, Trent M., Proctor, Lavinia M., Shiels, Ian A., Taylor, Stephen M., A. H. Wu and J. Delanghe (2006) Complement mediators in ischemia-reperfusion injury. Clinica Chimica Acta, 374 1-2: 33-45. doi:10.1016/j.cca.2006.06.010 68   61 Cited 64 times in Scopus64 0
Brennan, Faith H., Blomster, Linda V., Costantini, Alexander M., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia. In: Proceedings of the 11th International Congress of Neuroimmunology (ISNI). 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, (89-90). 4-8 November 2012. 72   0
Kotiw, Michael, Morgan, Michael, Taylor, Stephen M. and Shiels, Ian A. (2009) Detection of anti-TNFα activity in canine hyperimmune serum using a TNFα inhibition assay. Veterinary Clinical Pathology, 39 1: 46-52. doi:10.1111/j.1939-165X.2009.00166.x 59   1 Cited 1 times in Scopus1 0
Lee, John D., Kamaruzaman, Nur A., Fung, Jenny N. T., Taylor, Stephen M., Turner, Bradley J., Atkin, Julie D., Woodruff, Trent M. and Noakes, Peter G. (2013) Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 10 . doi:10.1186/1742-2094-10-119 56   5 Cited 6 times in Scopus6 3
Short, Anna, Wong, Allan K., Finch, Angela M., Haaima, Gerald, Shiels, Ian A., Fairlie, David P. and Taylor, Stephen M. (1999) Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. British Journal of Pharmacology, 126 2: 551-554. doi:10.1038/sj.bjp.0702338 46   51 Cited 56 times in Scopus56 0
Denny, Kerina J., Coulthard, Liam G., Finnell, Richard H., Callaway, Leonie K., Taylor, Stephen M. and Woodruff, Trent M. (2013) Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. Journal of Reproductive Immunology, 97 2: 211-216. doi:10.1016/j.jri.2012.11.006 41   6 Cited 7 times in Scopus7 0
Coulthard, Mark G., Morgan, Michael, Woodruff, Trent M., Arumugam, Thiruma V., Taylor, Stephen M., Carpenter, Todd C., Martin Lackmann, and Boyd, Andrew W. (2012) Eph/Ephrin signaling in injury and inflammation. American Journal of Pathology, 181 5: 1493-1503. doi:10.1016/j.ajpath.2012.06.043 80   16 Cited 17 times in Scopus17 0
Thundyil, John, Tang, Sung-Chun, Okun, Eitan, Shah, Kausik, Karamyan, Vardan T., Li , Yu-I, Woodruff, Trent M., Taylor, Stephen M., Jo, Dong-Gyu, Mattson, Mark P and Arumugam, Thiruma V. (2010) Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Experimental and Translational Stroke Medicine, 2 1: 15-1-15-8. doi:10.1186/2040-7378-2-15 57   Cited 17 times in Scopus17 0
Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2012). Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1169-1169). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.116 46   0 0
Pavlovski, Dale, Thundyil, John, Monk, Peter N., Wetsel, Rick A., Taylor, Stephen M. and Woodruff, Trent M. (2012) Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. The FASEB Journal, 26 9: 3680-3690. doi:10.1096/fj.11-202382 86   17 Cited 21 times in Scopus21 0
Shiels, Ian A., Bowler, Simon D. and Taylor, Stephen M. (1996) Homologous serum increases fibronectin expression and cell adhesion in airway smooth muscle cells. Inflammation, 20 4: 373-387. doi:10.1007/BF01486740 40   7 0
Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and R. A. North (2001) Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. British Journal of Pharmacology, 134 12: 1778-1786. doi:10.1038/sj.bjp.0704417 80   44 0
Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001). British Journal of Pharmacology, 135 2: 579-580. doi:10.1038/sj.bjp.0704531 60   0 0
Iyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay (2011) Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 58 5: 479-486. doi:10.1097/FJC.0b013e31822a7a09 38   12 Cited 12 times in Scopus12 1
Lee, John D., Lee, Jia Y., Taylor, Stephen M., Noakes, Peter G. and Woodruff, Trent M. (2012). Innate immunity in ALS. In Martin H. Maurer (Ed.), Amyotrophic lateral sclerosis (pp. 393-412) Croatia: InTech - Open Access Publisher. 118 3
Ager, Rahasson R., Fonseca, Maira I., Chu, Shu-Hui, Sanderson, Sam D., Taylor, Stephen M., Woodruff, Trent M. and Tenner, Andrea J. (2010) Microglial C5aR (CD88) expression correlates with amyloid-β deposition in murine models of Alzheimer's disease. Journal of Neurochemistry, 113 2: 389-401. doi:10.1111/j.1471-4159.2010.06595.x 49   21 Cited 27 times in Scopus27 0
Denny, Kerina J., Jeanes, Angela, Fathe, Kristin, Finnell, Richard H., Taylor, Stephen M. and Woodruff, Trent M. (2013) Neural tube defects, folate, and immune modulation. Birth Defects Research Part A - Clinical and Molecular Teratology, 97 9: 602-609. doi:10.1002/bdra.23177 20   4 Cited 5 times in Scopus5 0
Woodruff, Trent M., Thundyil, John, Tang, Sung Chun, Sobey, Christopher G., Taylor, Stephen M. and Arumugam, Thiruma V. (2011) Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Molecular Neurodegeneration, 6 1: 1-19. doi:10.1186/1750-1326-6-11 124   59 Cited 73 times in Scopus73 0
Morgan, Michael, Bulmer, Andrew C., Woodruff, Trent M., Proctor, Lavinia M., Williams, Hua M., Stocks, Shelli Z., Pollitt, Sandra, Taylor, Stephen M. and Shiels, Ian A (2008) Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration. European Journal of Pharmaceutical Sciences, 33 4-5: 390-398. doi:10.1016/j.ejps.2008.01.009 87   6 Cited 8 times in Scopus8 0
Arumugam, Thiruma V., Shiels, Ian A., Margolin, Solomon B., Taylor, Stephen M. and Brown, Lindsay (2002) Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine. Clinical And Experimental Pharmacology And Physiology, 29 11: 996-1000. doi:10.1046/j.1440-1681.2002.03766.x 59   18 Cited 20 times in Scopus20 0
March, Darren R., Proctor, Lavinia M., Stoermer, Martin J., Sbaglia, Robert, Abbenante, Giovanni, Reid, Robert C., Woodruff, Trent M., Wadi, Khemar, Paczkowski, Natalii, Tyndall, Joel D. A., Taylor, Stephen M. and Fairlie, David P. (2004) Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activity. Molecular Pharmacology, 65 4: 868-879. doi:10.1124/mol.65.4.868 80   42 Cited 39 times in Scopus39 0
Arumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004) Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 6: 934-941. doi:10.1016/j.jhep.2004.02.017 97   46 Cited 51 times in Scopus51 0
Arumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002) Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine. Journal of Surgical Research, 103 2: 260-267. doi:10.1006/jsre.2002.6369 68   70 Cited 73 times in Scopus73 0
Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004) Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 1: 81-90. doi:10.1016/j.jss.2003.04.001 131   49 Cited 52 times in Scopus52 0
Proctor, Lavinia M., Woodruff, Trent M. and Taylor, Stephen M. (2006) Recent developments in C5/C5a inhibitors. Expert Opinion On Therapeutic Patents, 16 4: 445-458. doi:10.1517/13543776.16.4.445 134   9 Cited 10 times in Scopus10 0
Woodruff, Trent M., Strachan, Anna J., Sanderson, Sam D., Monk, Peter N., Wong, Allan K., Fairlie, David P. and Taylor, Stephen M. (2001) Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes. Inflammation, 25 3: 171-177. doi:10.1023/A:1011036414353 55   34 Cited 35 times in Scopus35 0
Woodruff, Trent M., Wu, Mike C. L., Brennan, Faith H., Wetsel, Rick A., Ruitenberg, Marc J. and Taylor, Stephen M. (2012). The C3a receptor mediates protection from intestinal ischemia reperfusion injuries by impairing neutrophil mobilization. In: Abstracts of 24th International Complement Workshop (ICW). 24th International Complement Workshop (ICW), Chania, Crete, Greece, (1209-1209). 10-15 October 2012. doi:10.1016/j.imbio.2012.08.229 49   1 0
Crane, James W., Baiquni, Gilang P., Sullivan, Robert K. P., Lee, John D, Sah, Pankaj, Taylor, Stephen M, Noakes, Peter G. and Woodruff, Trent (2009) The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres. Journal of Neuroinflammation, 6 34: 34.1-34.10. doi:10.1186/1742-2094-6-34 75   5 Cited 5 times in Scopus5 0
Woodruff, Trent M., Costantini, Kerina J., Crane, James W., Atkin, Julie D., Monk, Peter N., Taylor, Stephen M. and Noakes, Peter G. (2008) The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral Sclerosis. Journal of Immunology, 181 12: 8727-8734. 109   47 Cited 46 times in Scopus46

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