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Huber, M., Scaletta, C., Benathan, M., Frenk, E., Greenhalgh, D. A., Rothnagel, J. A., Roop, D. R. and Hohl, D. (1994) Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations. Journal of Investigative Dermatology, 102 5: 691-694. doi:10.1111/1523-1747.ep12374270 62   12 Cited 10 times in Scopus10 3
Rothnagel, J. A., Fisher, M. P., Axtell, S. M., Pittelkow, M. R., Antonlamprecht, I., Huber, M., Hohl, D. and Roop, D. R. (1993) A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis. Human Molecular Genetics, 2 12: 2147-2150. doi:10.1093/hmg/2.12.2147 27   37 Cited 32 times in Scopus32 3
Arin, M. J., Longley, M. A., Kuster, W., Huber, M., Hohl, D., Rothnagel, J. A. and Roop, D. R. (1999) An aspatagine to threonine substitution in the 1A domain of keratin 1: A novel mutation that causes epidermolytic hyperkeratosis. Experimental Dermatology, 8 2: 124-127. doi:10.1111/j.1600-0625.1999.tb00359.x 46   11 0
Joh, G. Y., Traupe, H., Metze, D., Nashan, D., Huber, M., Hohl, D., Longley, M. A., Rothnagel, J. A. and Roop, D. R. (1997) A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma. Journal of Investigative Dermatology, 108 3: 357-361. doi:10.1111/1523-1747.ep12286491 31   27 Cited 32 times in Scopus32 0
Arin, M. J., Longley, M. A., Epstein, E. H., Scott, G., Goldsmith, L. A., Rothnagel, J. A. and Roop, D. R. (1999) A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens. Journal of Investigative Dermatology, 112 3: 380-382. doi:10.1046/j.1523-1747.1999.00529.x 41   5 Cited 6 times in Scopus6 3
Arin, M. J., Longley, M. A., Anton-Lamprecht, I., Kurze, G., Huber, M., Hohl, D., Rothnagel, J. A. and Roop, D. R. (1999) A novel substitution in keratin 10 in epidermolytic hyperkeratosis. Journal of Investigative Dermatology, 112 4: 506-508. doi:10.1046/j.1523-1747.1999.00557.x 42   12 Cited 15 times in Scopus15 0
Seki, T., Rothnagel, J. A., Bundman, D., Roop, D. R. and Adachi, K. (1996). Characterization of FAR-17a, androgen regulated gene expression in sebaceous glands. In: Hair Research for the Next Millenium. 1st Tricontinental Meeting of Hair Research Societies, Brussels Belgium, (371-374). 8-10 October 1995. 26   1
DiSepio, D., Bickenbach, J. R., Longley, M. A., Bundman, D. S., Rothnagel, J. A. and Roop, D. R. (1999) Characterization of loricrin regulation in vitro and in transgenic mice. Differentiation, 64 4: 225-235. doi:10.1046/j.1432-0436.1999.6440225.x 34   20 Cited 22 times in Scopus22 0
Greenhalgh, D. A., Quintanilla, M. I., Orengo, C. C., Barber, J. L., Eckhardt, J. N., Rothnagel, J. A. and Roop, D. R. (1993) Cooperation between v-fos and v-ras(HA) induces autonomous papillomas in transgenic epidermis but not malignant conversion. Cancer Research, 53 21: 5071-5075. 28   39 Cited 29 times in Scopus29
Roop, D. R., Rothnagel, J. A., Longley, M. A., Bundman, D. S., Dominey, A. M. and Greenhalgh, D. A. (1992). Development of Transgenic Mouse Models of Human Skin Diseases. In: Biology of the Epidermis : Molecular and Functional Aspects. 5th Japan - US Symposium On the Biology of the Epidermis, Niseko, Japan, (161-171). 21-25 July 1991. 22   1
Greenhalgh, D. A., Wang, X. J., Dominey, A. M., Rothnagel, J. A. and Roop, D. R. (1994). Development of transgenic mouse models of skin carcinogenesis: potential applications. In: Receptor-Mediated Biological Processes. 6th International Conference on Carcinogenesis and Risk Assessment - Receptor-Mediated Biological Processes: Implications for Evaluating Carcinogenesis, Austin Tx, (75-94). 8-11 December 1992. 12   3 Cited 3 times in Scopus3
Lu, B., Rothnagel, J. A., Longley, M. A., Tsai, S. Y. and Roop, D. R. (1994) Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. Journal of Biological Chemistry, 269 10: 7443-7449. 40   84 Cited 79 times in Scopus79
Wang, X. J., Greenhalgh, D. A., Eckhardt, J. N., Rothnagel, J. A. and Roop, D. R. (1994) Epidermal expression of transforming growth factor-α in transgenic mice: Induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression. Molecular Carcinogenesis, 10 1: 15-22. doi:10.1002/mc.2940100104 21   47 Cited 45 times in Scopus45 0
Greenhalgh, D. A., Rothnagel, J. A. and Roop, D. R. (1994). Epidermis: An attractive target tissue for gene therapy. In: 42nd Annual Symposium on the Biology of Skin - The Genetics of Skin Disease, Snowmass Village Co, (S63-S69). 24-28 July 1993. 17   63 Cited 75 times in Scopus75
Wojcik, Sonja M., Imakado, Sumihisa, Seki, Toshihiko, Longley, Mary A., Petherbridge, L., Bundman, Donnie S., Bickenbach, Jackie R., Rothnagel, Joseph A. and Roop, D. R. (1999) Expression of MK6a dominant-negative and C-terminal mutant transgenes has distinct phenotypic consequences in the epidermis and hair-follicle. Differentiation, 65 2: 97-112. doi:10.1046/j.1432-0436.1999.6520097.x 71   22 Cited 19 times in Scopus19 0
Greenhalgh, D. A., Rothnagel, J. A., Wang, X. J., Quintanilla, M. I., Orengo, C. C., Gagne, T. A., Bundman, D. S., Longley, M. A., Fisher, C. and Roop, D. R. (1993) Hyperplasia, Hyperkeratosis and Benign-Tumor Production in Transgenic Mice by a Targeted V-Fos Oncogene Suggest a Role for Fos in Epidermal Differentiation and Neoplasia. Oncogene, 8 8: 2145-2157. 50   58
Rothnagel, J. A., Greenhalgh, D. A., Gagne, T. A., Longley, M. A. and Roop, D. R. (1993) Identification of a calcium-inducible, epidermal-specific regulatory element in the 3'-flanking region of the human keratin 1 gene. Journal of Investigative Dermatology, 101 4: 506-513. doi:10.1111/1523-1747.ep12365886 25   56 Cited 50 times in Scopus50 0
Mehrel, T., Hohl, D., Rothnagel, J. A., Longley, M. A., Bundman, D., Cheng, C., Lichti, U., Bisher, M. E., Steven, A. C., Steinert, P. M., Yuspa, S. H. and Roop, D. R. (1990) Identification of a major keratinocyte cell envelope protein, loricrin. Cell, 61 6: 1103-1112. doi:10.1016/0092-8674(90)90073-N 26   345 Cited 258 times in Scopus258 0
Arin, M. J., Longley, M. A., Epstein, E. H., Rothnagel, J. A. and Roop, D. R. (2000) Identification of a novel mutation in keratin 1 in a family with epidermolytic hyperkeratosis. Experimental Dermatology, 9 1: 16-19. doi:10.1034/j.1600-0625.2000.009001016.x 41   7 Cited 9 times in Scopus9 0
Greenhalgh, D. A., Rothnagel, J. A., Quintanilla, M. I., Orengo, C. C., Gagne, T. A., Bundman, D. S., Longley, M. A. and Roop, D. R. (1993) Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene. Molecular Carcinogenesis, 7 2: 99-110. doi:10.1002/mc.2940070208 27   108 Cited 81 times in Scopus81 0
Sellheyer, K., Bickenbach, J. R., Rothnagel, J. A., Bundman, D., Longley, M. A., Krieg, T., Roche, N. S., Roberts, A. B. and Roop, D. R. (1993) Inhibition of skin development by overexpression of transforming growth factor β 1 in the epidermis of transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, 90 11: 5237-5241. doi:10.1073/pnas.90.11.5237 18   195 Cited 169 times in Scopus169 0
Bickenbach, J. R., Greer, J. M., Bundman, D. S., Rothnagel, J. A. and Roop, D. R. (1995) Loricrin Expression Is Coordinated with Other Epidermal Proteins and the Appearance of Lipid Lamellar Grannies in Development. Journal of Investigative Dermatology, 104 3: 405-410. doi:10.1111/1523-1747.ep12665896 30   77 0
Roop, D. R., Rothnagel, J. A., Greenhalgh, D. A., Longley, M. A., Bundman, D., Chung, S., Steinert, P. M., Ellis, C. N., Voorhees, J. J., Huff, C. A., Yuspa, S. H. and Rosenthal, D. S. (1991). Modulation of Epidermal Differentiation by Retinoids. In: Retinoids : 10 Years On. Retinoid Symposium, Geneva Switzerland, (28-37). 16-17 November 1990. 24   5
Rothnagel, J. A., Wojcik, S., Liefer, K. M., Dominey, A. M., Huber, M., Hohl, D. and Roop, D. R. (1995) Mutations in the 1A domain of keratin 9 in patients with epidermolytic palmoplantar keratoderma. Journal of Investigative Dermatology, 104 3: 430-433. doi:10.1111/1523-1747.ep12666018 20   48 Cited 54 times in Scopus54 0
Rothnagel, J. A., Traupe, H., Wojcik, S., Huber, M., Hohl, D., Pittelkow, M. R., Saeki, H., Ishibashi, Y. and Roop, D. R. (1994) Mutations in the Rod Domain of Keratin 2E in Patients with Ichthyosis Bullosa of Siemens. Nature Genetics, 7 4: 485-490. doi:10.1038/ng0894-485 33   108 Cited 103 times in Scopus103 3
Rothnagel, J. A., Dominey, A. M., Dempsey, L. D., Longley, M. A., Greenhalgh, D. A., Gagne, T. A., Huber, M., Frenk, E., Hohl, D. and Roop, D. R. (1992) Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis. Science, 257 5073: 1128-1130. doi:10.1126/science.257.5073.1128 20   290 Cited 211 times in Scopus211 3
Rothnagel, J. A., Lin, M. T. S., Longley, M. A., Holder, R. A., Hazen, P. G., Levy, M. L. and Roop, D. R. (1998) Prenatal diagnosis for keratin mutations to exclude transmission of epidermolytic hyperkeratosis. Prenatal Diagnosis, 18 8: 826-830. doi:10.1002/(SICI)1097-0223(199808)18:8<826::AID-PD360>3.0.CO;2-5 31   11 Cited 16 times in Scopus16 0
Rothnagel, J. A., Longley, M. A., Holder, R. A., Kuster, W. and Roop, D. R. (1994) Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing. Journal of Investigative Dermatology, 102 1: 13-16. doi:10.1111/1523-1747.ep12371723 23   40 Cited 38 times in Scopus38 3
Brown, L. J., Geesin, J. C., Rothnagel, J. A., Roop, D. R. and Gordon, J. S. (1994) Retinoic acid suppression of loricrin expression in reconstituted human skin cultured at the liquid-air interface. Journal of Investigative Dermatology, 102 6: 886-890. doi:10.1111/1523-1747.ep12382905 23   17 Cited 18 times in Scopus18 0
Dominey, A. M., Wang, X. J., King, L. E., Nanney, L. B., Gagne, T. A., Sellheyer, K., Bundman, D. S., Longley, M. A., Rothnagel, J. A., Greenhalgh, D. A. and Roop, D. R. (1993) Targeted Overexpression of Transforming Growth-Factor-Alpha in the Epidermis of Transgenic Mice Elicits Hyperplasia, Hyperkeratosis, and Spontaneous, Squamous Papillomas. Cell Growth & Differentiation, 4 12: 1071-1082. 22   152 Cited 124 times in Scopus124
Imakado, S., Bickenbach, J. R., Bundman, D. S., Rothnagel, J. A., Attar, P. S., Wang, X. J., Walczak, V. R., Wisniewski, S., Pote, J., Gordon, J. S., Heyman, R. A., Evans, R. M. and Roop, D. R. (1995) Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Genes & Development, 9 3: 317-329. doi:10.1101/gad.9.3.317 24   111 Cited 104 times in Scopus104 0
Rothnagel, J. A., Longley, M. A., Bundman, D., Greenhalgh, D. A., Dominey, A. M. and Roop, D. R. (1990). Targeting gene expression to the epidermis of transgenic mice: Potential applications to genetic skin disorders. In: Psoriasis Workshop : Molecular, Immunologic and Pharmacologic Aspects of Psoriasis, Deer Valley Ut, (S59-S61). 14-17 September 1989. doi:10.1111/1523-1747.ep12505805 21   20 Cited 8 times in Scopus8 0
Rothnagel, J. A., Mehrel, T., Idler, W. W., Roop, D. R. and Steinert, P. M. (1987) The gene for mouse epidermal filaggrin precursor. Its partial characterization, expression, and sequence of a repeating filaggrin unit. Journal of Biological Chemistry, 262 32: 15643-15648. 28   86 Cited 51 times in Scopus51
DiSepio, D., Jones, A., Longley, M. A., Bundman, D., Rothnagel, J. A. and Roop, D. R. (1995) The proximal promoter of the mouse loricrin gene contains a functional AP- 1 element and directs keratinocyte-specific but not differentiation-specific expression. Journal of Biological Chemistry, 270 18: 10792-10799. doi:10.1074/jbc.270.18.10792 23   95 Cited 90 times in Scopus90 0
Greenhalgh, D. A., Wang, X. J., Rothnagel, J. A., Eckhardt, J. N., Quintanilla, M. I., Barber, J. L., Bundman, D. S., Longley, M. A., Schlegel, R. and Roop, D. R. (1994) Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, ras(Ha)-activated papillomas. Cell Growth & Differentiation, 5 6: 667-675. 34   44 Cited 37 times in Scopus37
Rothnagel, J. A., Greenhalgh, D. A., Wang, X. J., Sellheyer, K., Bickenbach, J. R., Dominey, A. M. and Roop, D. R. (1993) Transgenic models of skin diseases. Archives of Dermatology, 129 11: 1430-1436. doi:10.1001/archderm.129.11.1430 26   24 Cited 19 times in Scopus19 0