Browse by all authors Browse By Author Name - Richardson,+Des+R.

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Richardson, Des R., Kalinowski, Danuta S., Richardson, Vera, Sharpe, Philip C., Lovejoy, David B., Islam, Mohammad and Bernhardt, Paul V. (2009) 2-acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: Redox activity, iron complexation and characterization of their antitumor activity. Journal of Medicinal Chemistry, 52 5: 1459-1470. doi:10.1021/jm801585u 128   72 Cited 73 times in Scopus73 0
Stefani, Christian, Jansson, Patric J., Gutierrez, Elaine, Bernhardt, Paul V., Richardson, Des R. and Kalinowski, Danuta S. (2013) Alkyl substituted 2′-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. Journal of Medicinal Chemistry, 56 1: 357-370. doi:10.1021/jm301691s 52   5 Cited 6 times in Scopus6 0
Becker, Erika and Richardson, Des R. (1999) Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs. Journal of Laboratory and Clinical Medicine, 134 5: 510-521. doi:10.1016/S0022-2143(99)90173-7 103   61 Cited 61 times in Scopus61 0
Stefani, Christian, Punnia-Moorthy, Gaya, Lovejoy, David B., Jansson, Patric J., Kalinowski, Danuta S., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2011) Halogenated 2′-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: Relationship to intracellular redox activity. Journal of Medicinal Chemistry, 54 19: 6936-6948. doi:10.1021/jm200924c 60   11 Cited 11 times in Scopus11 0
Basha, Maram T., Chartres, Jy D., Pantarat, Namfon, Ali, Mohammad Akbar, Mirza, Aminul Huq, Kalinowski, Danuta S., Richardson, Des R. and Bernhardt, Paul V. (2012) Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity. Dalton Transactions, 41 21: 6536-6548. doi:10.1039/c2dt12387h 96   11 Cited 9 times in Scopus9 1
Bernhardt, Paul V., Sharpe, Philip C., Islam, Mohammed, Lovejoy, David B., Kalinowski, Danuta S. and Richardson, Des R. (2009) Iron chelators of the dipyridylketone thiosemicarbazone class: Precomplexation and transmetalation effects on anticancer activity. Journal of Medicinal Chemistry, 52 2: 407-415. doi:10.1021/jm801012z 94   2 Cited 59 times in Scopus59 0
Basha, Maram T., Rodríguez, Carlos, Richardson, Des R., Martínez, Manuel and Bernhardt, Paul V. (2013) Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia. Journal of Biological Inorganic Chemistry, 19 3: 349-357. doi:10.1007/s00775-013-1070-9 54   1 Cited 1 times in Scopus1 0
Quach, Patricia, Gutierrez, Elaine, Basha, Maram Talal, Kalinowski, Danuta S., Sharpe, Philip C., Lovejoy, David B., Bernhardt, Paul V., Jansson, Patric J. and Richardson, Des R. (2012) Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect. Molecular Pharmacology, 82 1: 105-114. doi:10.1124/mol.112.078964 37   13 Cited 14 times in Scopus14 0
Bernhardt, Paul V., Chin, Piao, Sharpe, Philip C., Wang, Jing-Yan C. and Richardson, Des R. (2005) Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity. Journal of Biological Inorganic Chemistry, 10 7: 761-777. doi:10.1007/s00775-005-0018-0 109   43 Cited 45 times in Scopus45 0
Lovejoy, David B., Sharp, Danae M., Seebacher, Nicole, Obeidy, Peyman, Prichard, Thomas, Stefani, Christian, Basha, Maram T., Sharpe, Philip C., Jansson, Patric J., Kalinowski, Danuta S., Bernhardt, Paul V. and Richardson, Des R. (2012) Novel second-generation Di-2-Pyridylketone Thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. Journal of Medicinal Chemistry, 55 16: 7230-7244. doi:10.1021/jm300768u 76   29 Cited 29 times in Scopus29 0
Jansson, Patric J., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2010) Novel thiosemicarbazones of the ApT and DpT Series and their copper complexes: Identification of pronounced redox activity and characterization of their antitumor activity. Journal of Medicinal Chemistry, 53 15: 5759-5769. doi:10.1021/jm100561b 48   43 Cited 46 times in Scopus46 0
Chin, Alex P., Bernhardt, Paul V. and Richardson, Des R. (2003). Orally active Chelators for the treatment of iron overload diseases. In: Journal of Inorganic Biochemistry: Abstracts of the 11th International Conference on Biological Inorganic Chemistry. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, (118-118). 19-23 July, 2003. doi:10.1016/S0162-0134(03)80592-5 77   0 Cited 0 times in Scopus0 0
Kalinowski, Danuta S., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2008) Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: The methyl pyrazinylketone isonicotinoyl hydrazone series. Journal of Medicinal Chemistry, 51 2: 331-344. doi:10.1021/jm7012562 89   46 Cited 49 times in Scopus49 0
Sharpe, Philip C., Richardson, Des R., Kalinowski, Danuta S. and Bernhardt, Paul V. (2011) Synthetic and natural products as iron chelators. Current Topics in Medicinal Chemistry, 11 5: 591-607. doi:10.2174/156802611794785163 77 1 10 Cited 12 times in Scopus12 0
Kovacevic, Zaklina, Kalinowski, Danuta S., Lovejoy, David B., Yu, Yu, Rahmanto, Yohan Suryo, Sharpe, Phillip C., Bernhardt, Paul V. and Richardson, Des R. (2011) The medicinal chemistry of novel iron chelators for the treatment of cancer. Current Topics in Medicinal Chemistry, 11 5: 483-499. doi:10.2174/156802611794785190 67 1 30 Cited 34 times in Scopus34 0
Yu, Yu, Kalinowski, Danuta S., Kovacevic, Zaklina, Siafakas, Aritee R., Jansson, Patric J., Stefani, Christian, Lovejoy, David B., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2009) Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitors. Journal of Medicinal Chemistry, 52 17: 5271-5294. doi:10.1021/jm900552r 72   112 Cited 111 times in Scopus111 0