Browse by all authors Browse By Author Name - Richardson,+Des+R.

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Richardson, Des R., Kalinowski, Danuta S., Richardson, Vera, Sharpe, Philip C., Lovejoy, David B., Islam, Mohammad and Bernhardt, Paul V. (2009) 2-acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: Redox activity, iron complexation and characterization of their antitumor activity. Journal of Medicinal Chemistry, 52 5: 1459-1470. doi:10.1021/jm801585u 119   69 Cited 71 times in Scopus71 0
Stefani, Christian, Jansson, Patric J., Gutierrez, Elaine, Bernhardt, Paul V., Richardson, Des R. and Kalinowski, Danuta S. (2013) Alkyl substituted 2′-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. Journal of Medicinal Chemistry, 56 1: 357-370. doi:10.1021/jm301691s 49   3 Cited 5 times in Scopus5 0
Becker, Erika and Richardson, Des R. (1999) Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs. Journal of Laboratory and Clinical Medicine, 134 5: 510-521. doi:10.1016/S0022-2143(99)90173-7 101   60 Cited 61 times in Scopus61 0
Stefani, Christian, Punnia-Moorthy, Gaya, Lovejoy, David B., Jansson, Patric J., Kalinowski, Danuta S., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2011) Halogenated 2′-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: Relationship to intracellular redox activity. Journal of Medicinal Chemistry, 54 19: 6936-6948. doi:10.1021/jm200924c 58   11 Cited 10 times in Scopus10 0
Basha, Maram T., Chartres, Jy D., Pantarat, Namfon, Ali, Mohammad Akbar, Mirza, Aminul Huq, Kalinowski, Danuta S., Richardson, Des R. and Bernhardt, Paul V. (2012) Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity. Dalton Transactions, 41 21: 6536-6548. doi:10.1039/c2dt12387h 93   10 Cited 8 times in Scopus8 1
Bernhardt, Paul V., Sharpe, Philip C., Islam, Mohammed, Lovejoy, David B., Kalinowski, Danuta S. and Richardson, Des R. (2009) Iron chelators of the dipyridylketone thiosemicarbazone class: Precomplexation and transmetalation effects on anticancer activity. Journal of Medicinal Chemistry, 52 2: 407-415. doi:10.1021/jm801012z 89   2 Cited 55 times in Scopus55 0
Basha, Maram T., Rodríguez, Carlos, Richardson, Des R., Martínez, Manuel and Bernhardt, Paul V. (2013) Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia. Journal of Biological Inorganic Chemistry, 19 3: 349-357. doi:10.1007/s00775-013-1070-9 45   1 Cited 1 times in Scopus1 0
Quach, Patricia, Gutierrez, Elaine, Basha, Maram Talal, Kalinowski, Danuta S., Sharpe, Philip C., Lovejoy, David B., Bernhardt, Paul V., Jansson, Patric J. and Richardson, Des R. (2012) Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect. Molecular Pharmacology, 82 1: 105-114. doi:10.1124/mol.112.078964 30   12 Cited 14 times in Scopus14 0
Bernhardt, Paul V., Chin, Piao, Sharpe, Philip C., Wang, Jing-Yan C. and Richardson, Des R. (2005) Novel diaroylhydrazine ligands as iron chelators: coordination chemistry and biological activity. Journal of Biological Inorganic Chemistry, 10 7: 761-777. doi:10.1007/s00775-005-0018-0 103   43 Cited 45 times in Scopus45 0
Lovejoy, David B., Sharp, Danae M., Seebacher, Nicole, Obeidy, Peyman, Prichard, Thomas, Stefani, Christian, Basha, Maram T., Sharpe, Philip C., Jansson, Patric J., Kalinowski, Danuta S., Bernhardt, Paul V. and Richardson, Des R. (2012) Novel second-generation Di-2-Pyridylketone Thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. Journal of Medicinal Chemistry, 55 16: 7230-7244. doi:10.1021/jm300768u 75   23 Cited 24 times in Scopus24 0
Jansson, Patric J., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2010) Novel thiosemicarbazones of the ApT and DpT Series and their copper complexes: Identification of pronounced redox activity and characterization of their antitumor activity. Journal of Medicinal Chemistry, 53 15: 5759-5769. doi:10.1021/jm100561b 47   38 Cited 41 times in Scopus41 0
Chin, Alex P., Bernhardt, Paul V. and Richardson, Des R. (2003). Orally active Chelators for the treatment of iron overload diseases. In: Journal of Inorganic Biochemistry: Abstracts of the 11th International Conference on Biological Inorganic Chemistry. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, (118-118). 19-23 July, 2003. doi:10.1016/S0162-0134(03)80592-5 74   0 Cited 0 times in Scopus0 0
Kalinowski, Danuta S., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2008) Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: The methyl pyrazinylketone isonicotinoyl hydrazone series. Journal of Medicinal Chemistry, 51 2: 331-344. doi:10.1021/jm7012562 88   44 Cited 47 times in Scopus47 0
Sharpe, Philip C., Richardson, Des R., Kalinowski, Danuta S. and Bernhardt, Paul V. (2011) Synthetic and natural products as iron chelators. Current Topics in Medicinal Chemistry, 11 5: 591-607. doi:10.2174/156802611794785163 76 1 9 Cited 9 times in Scopus9 0
Kovacevic, Zaklina, Kalinowski, Danuta S., Lovejoy, David B., Yu, Yu, Rahmanto, Yohan Suryo, Sharpe, Phillip C., Bernhardt, Paul V. and Richardson, Des R. (2011) The medicinal chemistry of novel iron chelators for the treatment of cancer. Current Topics in Medicinal Chemistry, 11 5: 483-499. doi:10.2174/156802611794785190 65 1 29 Cited 31 times in Scopus31 0
Yu, Yu, Kalinowski, Danuta S., Kovacevic, Zaklina, Siafakas, Aritee R., Jansson, Patric J., Stefani, Christian, Lovejoy, David B., Sharpe, Philip C., Bernhardt, Paul V. and Richardson, Des R. (2009) Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitors. Journal of Medicinal Chemistry, 52 17: 5271-5294. doi:10.1021/jm900552r 71   105 Cited 108 times in Scopus108 0