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Rowlinson, Scott W., Yoshizato, Hideo, Barclay, Johanna L., Brooks, Andrew J., Behncken, Stuart N., Kerr, Linda M., Millard, Kirstin, Palethorpe, Kathryn, Nielsen, Katherine, Clyde-Smith, Jodie, Hancock, John F. and Waters, Michael J. (2008) An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway. Nature Cell Biology, 10 6: 740-747. doi:10.1038/ncb1737 93   32 Cited 39 times in Scopus39 0
Crouthamel, Marykate, Abankwa, Daniel, Zhang, Li, DiLizio, Cherisse, Manning, David R., Hancock, John F. and Wedegaertner, Philip B. (2010) An N-terminal polybasic motif of G alpha(q) is required for signaling and influences membrane nanodomain distribution. Molecular Pharmacology, 78 4: 767-777. doi:10.1124/mol.110.066340 61   3 Cited 3 times in Scopus3 0
Abankwa, Daniel, Hanzal-Bayer, Michael, Ariotti, Nicolas, Plowman, Sarah J., Gorfe, Alemayehu A, Parton, Robert G., McCammon, J. Andrew and Hancock, John F. (2008) A novel switch region regulated H-ras membrane orientation and signal output. The EMBO journal, 27 5: 727-735. doi:10.1038/emboj.2008.10 75   71 Cited 73 times in Scopus73 0
Ariotti, Nicholas, Fernández-Rojo, Manuel, Zhou, Yong, Hill, Michelle M., Rodkey, Travis L., Inder, Kerry L., Tanner, Lukas B., Wenk, Markus R., Hancock, John F. and Parton, Robert G. (2014) Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. Journal of Cell Biology, 204 5: 777-792. doi:10.1083/jcb.201307055 31   1 Cited 2 times in Scopus2 1
Fernández Rojo, Manuel, Gongora, Milena, Fitzsimmons, Rebecca L., Martel, Nick, Martin, Sheree D., Nixon, Susan, Brooks, Andrew J., Ikonomopoulou, Maria P., Martin, Sally, Lo, Harriet P., Myers, Stephen A., Restall, Christina, Ferguson, Charles, Pilch, Paul F., McGee, Sean L., Anderson, Robin L., Waters, Michael J., Hancock, John F., Grimmond, Sean M., Muscat, George E. and Parton, Robert G. (2013) Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Reports, 4 2: 238-247. doi:10.1016/j.celrep.2013.06.017 60   4 Cited 4 times in Scopus4 2
Chadda, Rahul, Howes, Mark T., Plowman, Sarah J., Hancock, John F., Parton, Robert G. and Mayor, Satyajit (2007) Cholesterol-Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway. Traffic, 8 6: 702-717. doi:10.1111/j.1600-0854.2007.00565.x 85   82 Cited 78 times in Scopus78 0
Howes, Mark T., Kirkham, Matthew, Riches, James, Cortese, Katia, Walser, Piers J., Simpson, Fiona, Hill, Michelle M., Jones, Alun, Lundmark, Richard, Lindsay, Margaret R., Hernandez-Deviez, Delia J., Hadzic, Gordana, McCluskey, Adam, Bashir, Rumasia, Liu, Libin, Pilch, Paul, McMahon, Harvey, Robinson, Phillip J., Hancock, John F., Mayor, Satyajit and Parton, Robert G. (2010) Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. Journal of Cell Biology, 190 4: 675-691. doi:10.1083/jcb.201002119 112   79 Cited 78 times in Scopus78 1
Walser, Piers, Ariotti, Nicholas, Howes, Mark, Ferguson, Charles, Webb, Richard, Schwudke, Dominik, Leneva, Natalya, Cho, Kwang-Jin, Cooper, Leanne, Rae, James, Floetenmeyer, Matthias, Oorschot, Viola M. J., Skoglund, Ulf, Simons, Kai, Hancock, John F. and Parton, Robert G. (2012) Constitutive formation of caveolae in a bacterium. Cell, 150 4: 752-763. doi:10.1016/j.cell.2012.06.042 72   14 Cited 15 times in Scopus15 15
Hill, Michelle M., Daud, Noor Huda, Aung, Cho Sanda, Loo, Dorothy, Martin, Sally, Murphy, Samantha, Black, Debra M., Barry, Rachael, Simpson, Fiona, Liu, Libin, Pilch, Paul F, Hancock, John F., Marie-Odile Parat and Parton, Robert G. (2012) Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1. PLoS One, 7 8: e43041.1-e43041.9. doi:10.1371/journal.pone.0043041 126 1 12 Cited 13 times in Scopus13 1
Ariotti, Nicholas, Liang, Hong, Xu, Yufei, Zhang, Yueqiang, Yonekubo, Yoshiya, Inder, Kerry, Du, Guangwei, Parton, Robert G., Hancock, John F. and Plowman, Sarah J. (2010) Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation. Molecular and Cellular Biology, 30 15: 3795-3804. doi:10.1128/MCB.01615-09 62   27 Cited 28 times in Scopus28 0
Kirkham, Matthew, Nixon, Susan J., Howes, Mark T., Abi-Rached, Laurent, Wakeham, Diane E., Hanzal-Bayer, Michael, Ferguson, Charles, Hill, Michelle M., Fernandez-Rojo, Manuel, Brown, Deborah A., Hancock, John F., Brodsky, Frances M. and Parton, Robert G. (2008) Evolutionary analysis and molecular dissection of caveola biogenesis. Journal of Cell Science, 121 12: 2075-2086. doi:10.1242/jcs.024588 51   40 Cited 44 times in Scopus44 0
van der Hoeven, Dharini, Cho, Kwang-jin, Ma, Xiaoping, Chigurupati, Sravanthi, Parton, Robert G. and Hancock, John F. (2013) Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Molecular and Cellular Biology, 33 2: 237-251. doi:10.1128/MCB.00884-12 32   13 Cited 13 times in Scopus13 1
Prior, Ian A., Harding, Angus, Yan, Jun, Sluimer, Judith, Parton, Robert G. and Hancock, John F. (2001) GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nature Cell Biology, 3 4: 368-375. doi:10.1038/35070050 66   335 Cited 338 times in Scopus338 0
Payne, Elizabeth, Bowles, Mark R., Don, Alistair, Hancock, John F. and McMillan, Nigel A. J. (2001) Human papillomavirus type 6b virus-like particles are able to activate the Ras-MAP kinase pathway and induce cell proliferation. Journal of Virology, 75 9: 4150-4157. doi:10.1128/JVI.75.9.4150-4157.2001 33   22 Cited 25 times in Scopus25 0
Nicolau, Dan V. (Jnr), Burrage, Kevin, Parton, Robert G. and Hancock, John F. (2006) Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane. Molecular and Cellular Biology, 26 1: 313-323. doi:10.1128/MCB.26.1.313-323.2006 62   98 Cited 103 times in Scopus103 1
Hancock, John F. (2006) Lipid rafts: contentious only from simplistic standpoints. Nature Reviews Molecular Cell Biology, 7 6: 456-462. doi:10.1038/nrm1925 68   464 Cited 475 times in Scopus475 0
Tian, Tianhai, Plowman, Sarah J., Parton, Robert G., Kloog, Yoel and Hancock, John F. (2010) Mathematical modeling of K-Ras nanocluster formation on the plasma membrane. Biophysical Journal, 99 2: 534-543. doi:10.1016/j.bpj.2010.04.055 45   16 Cited 16 times in Scopus16 0
Wilkins, Simon J., Yoong, Simon, Verkade, Heather, Mizoguchi, Takamasa, Plowman, Sarah J., Hancock, John F., Kikuchi, Yutaka, Heath, Joan K. and Perkins, Andrew C. (2008) Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation. Developmental Biology, 314 1: 12-22. doi:10.1016/j.ydbio.2007.10.050 62   18 Cited 19 times in Scopus19 0
Inder, Kerry L., Hill, Michelle M. and Hancock, John F. (2010) Nucleophosmin and nucleolin regulate K-Ras signaling. Communicative and Integrative Biology, 3 2: 188-190. doi:10.4161/cib.3.2.10923 39 27 0
Hancock, John F. (2007) PA promoted to manager. Nature Cell Biology, 9 6: 615-617. doi:10.1038/ncb0607-615 36   23 Cited 22 times in Scopus22 0
Jaumot, Montserrat and Hancock, John F. (2001) Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene, 20 30: 3949-3958. doi:10.1038/sj.onc.1204526 42   99 Cited 107 times in Scopus107 0
Salim, Angela A., Cho, Kwang-Jin, Tan, Lingxiao, Quezada, Michelle, Lacey, Ernest, Hancock, John F. and Capon, Robert J. (2014) Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras. Organic Letters, 16 19: 5036-5039. doi:10.1021/ol502376e 11   0 Cited 0 times in Scopus0 5
Salim, Angela A., Xiao, Xue, Cho, Kwang-Jin, Piggott, Andrew M., Lacey, Ernest, Hancock, John F. and Capon, Robert J. (2014) Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Organic and Biomolecular Chemistry, 12 27: 4872-4878. doi:10.1039/c4ob00745j 19   1 Cited 1 times in Scopus1 0
Abankwa, Daniel, Gorfe, Alemayehu A., Inder, Kerry and Hancock, John F. (2010) Ras membrane orientation and nanodomain localization generate isoform diversity. Proceedings of the National Academy of Sciences of the United States of America, 107 3: 1130-1135. doi:10.1073/pnas.0903907107 40   39 Cited 43 times in Scopus43 0
Abankwa, D, Gorfe, A.A and Hancock, John F. (2007) Ras nanoclusters: Molecular structure and assembly. Seminars in Cell and Developmental Bioloby, 18 5: 599-607. doi:10.1016/j.semcdb.2007.08.003 57   45 Cited 47 times in Scopus47 0
Hancock, John F. (2003) Ras proteins: Different signals from different locations. Nature Reviews Molecular Cell Biology, 4 5: 373-384. doi:10.1038/nrm1105 70   422 Cited 433 times in Scopus433 0
Hill, Michelle M., Scherbakov, Nadja, Schiefermeier, Natalia, Baran, JoAnne, Hancock, John F., Huber, Lukas A., Parton, Robert G. and Parat, Marie-Odile (2007) Reassessing the Role of Phosphocaveolin-1 in Cell Adhesion and Migration. Traffic, 8 12: 1695-1705. doi:10.1111/j.1600-0854.2007.00653.x 89   23 Cited 21 times in Scopus21 0
Zhou, Yong, Liang, Hong, Rodkey, Travis, Ariotti, Nicholas, Parton, Robert G. and Hancock, John F. (2013) Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters. Molecular and Cellular Biology, 34 5: 862-876. doi:10.1128/MCB.01227-13 25   2 Cited 2 times in Scopus2 0
Gambin, Yann, Ariotti, Nicholas, McMahon, Kerrie-Ann, Bastiani, Michele, Sierecki, Emma, Kovtun, Oleksiy, Polinkovsky, Mark E., Magenau, Astrid, Jung, WooRam, Okano, Satomi, Zhou, Yong, Leneva, Natalya, Mureev, Sergey, Johnston, Wayne, Gaus, Katharina, Hancock, John F., Collins, Brett M., Alexandrov, Kirill and Parton, Robert G. (2014) Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. eLIFE, e01434.1-e01434.18. doi:10.7554/eLife.01434 82 2 15
Nicolau Jr, D V, Hancock, John F. and Burrage, Kevin (2007) Sources of Anomalous Diffusion on Cell Membranes: A Monte Carlo Study. Biophysical journal, 92 6: 1975-1987. doi:10.1529/biophysj.105.076869 64   57 Cited 54 times in Scopus54 0
Cho, Kwang-jin, Park, Jin-Hee, Piggott, Andrew M., Salim, Angela A., Gorfe, Alemaheyu A., Parton, Robert G., Capon, Robert J., Lacey, Ernest and Hancock, John F. (2012) Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins. Journal of Biological Chemistry, 287 52: 43573-43584. doi:10.1074/jbc.M112.424457 64   14 Cited 16 times in Scopus16 3
Collins, Brett, Davis, Melissa, Hancock, John F. and Parton, Robert G. (2012) Structure-based reassessment of the caveolin signalling model: Do caveolae regulate signaling through caveolin-protein interactions. Developmental Cell, 23 1: 11-20. doi:10.1016/j.devcel.2012.06.012 47   17 Cited 18 times in Scopus18 0
Sykes, Alex M., Palstra, Nick, Abankwa, Daniel, Hill, Justine M., Skeldal, Sune, Matusica, Dusan, Venkatraman, Prahatha, Hancock, John F. and Coulson, Elizabeth J. (2012) The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase. Journal of Biological Chemistry, 287 52: 43810-43824. doi:10.1074/jbc.M112.382903 55   7 Cited 6 times in Scopus6 0
Cho, Kwang-jin, Hill, Michelle M., Chigurupati, Sravanthi, Du, Guangwei, Parton, Robert G. and Hancock, John F. (2011) Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate Ras signaling via phospholipase D2. Molecular and Cellular Biology, 31 6: 1110-1120. doi:10.1128/MCB.00989-10 67   7 Cited 9 times in Scopus9 0