Browse by all authors Browse By Author Name - Guddat,+Luke+W.

Browse Results (41 results found)

Subscribe to the RSS feed for this result setSubscribe to the RSS feed for this result set

  Abstract Views File Downloads Thomson Reuters Web of Science Citation Count Scopus Citation Count Altmetric Score
de Jersey, John, Holý, Antonín, Hocková, Dana, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2011) 6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry, 11 16: 2085-2102. doi:10.2174/156802611796575911 119 2 12 Cited 13 times in Scopus13 0
Pue, Nason and Guddat, Luke W. (2013) Acetohydroxyacid synthase: A target for antimicrobial drug discovery. Current Pharmaceutical Design, 19 1-17. 116 5 Cited 1 times in Scopus1
Keough, Dianne T., Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2013) Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry, 56 6: 2513-2526. doi:10.1021/jm301893b 39   8 Cited 8 times in Scopus8 0
Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W. and Ferro, Vito (2012) A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorganic & Medicinal Chemistry Letters, 22 19: 6190-6194. doi:10.1016/j.bmcl.2012.08.001 51   1 Cited 1 times in Scopus1 1
Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, James S. and Andrews, Katherine T. (2005) Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply. Journal of Infectious Diseases, 191 8: 1382-1383. doi:10.1086/428782 103   3 Cited 12 times in Scopus12 0
Wong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012) Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 3-4: 168-179. doi:10.1016/j.jmb.2012.09.018 79   3 Cited 3 times in Scopus3 0
Schenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012) Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 9: 1593-1603. doi:10.1021/ar300067g 88   13 Cited 16 times in Scopus16 0
Wang, Jianguo, Tan, Haizhong, Li, Yonghong, Ma, Yi, Li, Zhengming and Guddat, Luke W. (2011) Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. Journal of Agricultural and Food Chemistry, 59 18: 9892-9900. doi:10.1021/jf2021607 58   8 Cited 7 times in Scopus7 0
Leung, Eleanor W. W. and Guddat, Luke W. (2009) Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures. Journal of Molecular Biology, 389 1: 167-182. doi:10.1016/j.jmb.2009.04.012 65   11 Cited 12 times in Scopus12 0
Millers, Emma-Karin K., Trabi, Manuela, Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2009) Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS Journal, 276 11: 3163-3175. doi:10.1111/j.1742-4658.2009.07034.x 60   16 Cited 16 times in Scopus16 0
Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008) Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 6: 1-13. doi:10.1186/1472-6807-8-6 69   38 Cited 33 times in Scopus33 0
Wang, Jian-Guo, Lee, Patrick K.-M., Dong, Yu-Hui, Pang, Siew Siew, Duggleby, Ronald G., Li, Zheng-Ming and Guddat, Luke W. (2009) Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS Journal, 276 5: 1282-1290. doi:10.1111/j.1742-4658.2009.06863.x 85   21 Cited 21 times in Scopus21 0
Pedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014) Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 3: 389-398. doi:10.1007/s00775-013-1079-0 45   1 Cited 0 times in Scopus0 0
Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008) Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 1-8. doi:10.1186/1756-0500-1-78 74   Cited 3 times in Scopus3 0
Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012) Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 5: 665-674. doi:10.1111/j.1747-0285.2012.12001.x 99   2 Cited 2 times in Scopus2 2
Keough, Dianne T., Hockova, Dana, Holy, Antonin, Naesens, Lieve M. J., Skinner-Adams, Tina S., de Jersey, John and Guddat, Luke W. (2009) Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics. Journal of Medicinal Chemistry, 52 14: 4391-4399. doi:10.1021/jm900267n 76   35 Cited 34 times in Scopus34 0
McGeary, Ross P., Vella, Peter, Mak, Jeffery Y. W., Guddat, Luke W. and Schenk, Gerhard (2009) Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorganic & Medicinal Chemistry Letters, 19 1: 163-166. doi:10.1016/j.bmcl.2008.10.125 86   16 Cited 17 times in Scopus17 0
Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013) Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 17: 6967-6984. doi:10.1021/jm400779n 37   4 Cited 4 times in Scopus4 0
Keough, Dianne T., Skinner-Adams, Tina, Jones, Malcolm K., Ng, Ai-Lin., Brereton, Ian M., Guddat, Luke W. and de Jersey, John (2006) Lead compounds for antimalarial chemotherapy: Purine base analogs discriminate between human and P-falciparum 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 49 25: 7479-7486. doi:10.1021/jm061012j 135   30 Cited 26 times in Scopus26 0
Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012) Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 7: 2555-2559. doi:10.1016/j.bmcl.2012.01.123 56   0 Cited 1 times in Scopus1 0
Ely, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012) Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 1: 19-22. doi:10.1016/j.jinorgbio.2011.09.015 59   6 Cited 5 times in Scopus5 0
Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004) Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 2: 154-162. doi:10.1016/j.abb.2004.01.008 122   34 Cited 35 times in Scopus35 0
Keough, Dianne T., Hockova, Daná, Krečmerová, Marcela, Česnek, Michal, Holý, Antonín, Naesens, Lieve, Brereton, Ian M., Winzor, Donald J., de Jersey, John and Guddat, Luke W. (2010) Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology, 173 2: 165-169. doi:10.1016/j.molbiopara.2010.05.018 49   14 Cited 14 times in Scopus14 0
Tyagi, Rajiv, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005) Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. Febs Journal, 272 2: 593-602. doi:10.1111/j.1742-4658.2004.04506.x 53   13 Cited 16 times in Scopus16 0
Naesens, Lieve, Guddat, Luke W., Keough, Dianne T., van Kuilenburg, André B. P., Meijer, Judith, Vande Voorde, Johan and Balzarini, Jan (2013) Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Molecular Pharmacology, 84 4: 615-629. doi:10.1124/mol.113.087247 27   3 Cited 5 times in Scopus5 0
Lavin, Martin F., Earl, Stephen, Birrell, Geoff, St. Pierre, Liam, Guddat, Luke W., John de Jersey and Masci, Paul (2009). Snake venom nerve growth factors. In Stephen P Mackessy (Ed.), Handbook of Venoms and Toxins of Reptiles 1st ed. (pp. 377-392) United States of America: CRC Press, Taylor & Francis Group. 102  
Wang, Jian-Guo, Li, Zheng-Ming, Ma, Zheng-Ming, Wang, Bao-Lei, Jiang, Lin, Pang, Siew Siew, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005) Structure-activity relationships for a new family of sulfonylurea herbicides. Journal of Computer-aided Molecular Design, 19 11: 801-820. doi:10.1007/s10822-005-9028-9 240   33 Cited 31 times in Scopus31 0
Duggleby, R.G., McCourt, J.A. and Guddat, Luke W. (2008) Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiology and Biochemistry, 2008 46: 309-324. 96   Cited 72 times in Scopus72
Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007) Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8 21-31. 136  
Lee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013) Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 1: 210-219. doi:10.1021/jm301501k 47   4 Cited 6 times in Scopus6 0
Cesnek, Michael, Hockova, Dana, Holy, Antonín, Dracinsky, Martin, Baszczynski, Ondřej, de Jersey, John, Keough, Dianne T. and Guddat, Luke W. (2011) Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 20 2: 1076-1089. doi:10.1016/j.bmc.2011.11.034 42   10 Cited 12 times in Scopus12 1
Hockova, Dana, Holy, Antonín, Masojidkova, Milena, Keough, Dianne T., de Jersey, John and Guddat, Luke W. (2009) Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic & Medicinal Chemistry, 17 17: 6218-6232. doi:10.1016/j.bmc.2009.07.044 47   47 Cited 45 times in Scopus45 0
Hockova, Dana, Keough, Dianne T., Janeba, Zlatko, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2012) Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 55 13: 6209-6223. doi:10.1021/jm300662d 45   14 Cited 15 times in Scopus15 0
Krecmerova, Marcela, Dracinsky, Martin, Hockova, Dana, Holy, Antonín, Keough, Dianne T. and Guddat, Luke W. (2012) Synthesis of purine N-9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry, 20 3: 1222-1230. doi:10.1016/j.bmc.2011.12.034 48   6 Cited 6 times in Scopus6 0
Duggleby, Ronald G., Pang, Siew Siew, Yu, Hongqi and Guddat, Luke W. (2003) Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data. European Journal of Biochemistry, 270 13: 2895-2904. doi:10.1046/j.1432-1033.2003.03671.x 40   47 Cited 52 times in Scopus52 0
McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014) The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76 132-144. doi:10.1016/j.ejmech.2014.02.008 30   1 Cited 1 times in Scopus1 0
Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006) The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 8: 3338-3363. doi:10.1021/cr050318f 98   194 Cited 192 times in Scopus192 0
Keough, Dianne T., Brereton, Ian M., De Jersey, John and Guddat, Luke W. (2005) The crystal structure of free human hypoxanthineguanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. Journal of Molecular Biology, 351 1: 170-181. doi:10.1016/j.jmb.2005.05.061 92   20 Cited 19 times in Scopus19 0
Baszczynski, Ondrej, Hockova, Dana, Janeba, Zlatko, Holy, Antonin, Jansa, Petr, Dracinsky, Martin, Keough, Dianne T. and Guddat, Luke W. (2013) The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. European Journal of Medicinal Chemistry, 67 81-89. doi:10.1016/j.ejmech.2013.06.032 21   2 Cited 2 times in Scopus2 1
Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010) The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 3: 565-573. doi:10.1042/BJ20101054 68   13 Cited 12 times in Scopus12 0
Millers, Emma-Karin I., Johnson, Lambro A., Birrell, Geoff W., Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2013) The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One, 8 1: e54104.1-e54104.12. doi:10.1371/journal.pone.0054104 47   3 Cited 3 times in Scopus3 2