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de Jersey, John, Holý, Antonín, Hocková, Dana, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2011) 6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry, 11 16: 2085-2102. doi:10.2174/156802611796575911 127 2 13 Cited 15 times in Scopus15 0
Pue, Nason and Guddat, Luke W. (2013) Acetohydroxyacid synthase: A target for antimicrobial drug discovery. Current Pharmaceutical Design, 19 1-17. 120 5 Cited 2 times in Scopus2
Keough, Dianne T., Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2013) Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry, 56 6: 2513-2526. doi:10.1021/jm301893b 44   9 Cited 10 times in Scopus10 0
Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W. and Ferro, Vito (2012) A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorganic & Medicinal Chemistry Letters, 22 19: 6190-6194. doi:10.1016/j.bmcl.2012.08.001 52   2 Cited 1 times in Scopus1 1
Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, James S. and Andrews, Katherine T. (2005) Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply. Journal of Infectious Diseases, 191 8: 1382-1383. doi:10.1086/428782 105   3 Cited 12 times in Scopus12 0
Wong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012) Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 3-4: 168-179. doi:10.1016/j.jmb.2012.09.018 86   3 Cited 3 times in Scopus3 0
Schenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012) Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 9: 1593-1603. doi:10.1021/ar300067g 94   18 Cited 20 times in Scopus20 0
Wang, Jianguo, Tan, Haizhong, Li, Yonghong, Ma, Yi, Li, Zhengming and Guddat, Luke W. (2011) Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. Journal of Agricultural and Food Chemistry, 59 18: 9892-9900. doi:10.1021/jf2021607 64   9 Cited 9 times in Scopus9 0
Leung, Eleanor W. W. and Guddat, Luke W. (2009) Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures. Journal of Molecular Biology, 389 1: 167-182. doi:10.1016/j.jmb.2009.04.012 66   12 Cited 13 times in Scopus13 0
Millers, Emma-Karin K., Trabi, Manuela, Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2009) Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS Journal, 276 11: 3163-3175. doi:10.1111/j.1742-4658.2009.07034.x 61   17 Cited 17 times in Scopus17 0
Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008) Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 6: 1-13. doi:10.1186/1472-6807-8-6 73   39 Cited 34 times in Scopus34 3
Wang, Jian-Guo, Lee, Patrick K.-M., Dong, Yu-Hui, Pang, Siew Siew, Duggleby, Ronald G., Li, Zheng-Ming and Guddat, Luke W. (2009) Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS Journal, 276 5: 1282-1290. doi:10.1111/j.1742-4658.2009.06863.x 93   22 Cited 23 times in Scopus23 0
Pedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014) Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 3: 389-398. doi:10.1007/s00775-013-1079-0 46   1 Cited 1 times in Scopus1 0
Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008) Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 1-8. doi:10.1186/1756-0500-1-78 75   Cited 3 times in Scopus3 0
Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012) Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 5: 665-674. doi:10.1111/j.1747-0285.2012.12001.x 104   3 Cited 4 times in Scopus4 2
Keough, Dianne T., Hockova, Dana, Holy, Antonin, Naesens, Lieve M. J., Skinner-Adams, Tina S., de Jersey, John and Guddat, Luke W. (2009) Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics. Journal of Medicinal Chemistry, 52 14: 4391-4399. doi:10.1021/jm900267n 77   36 Cited 37 times in Scopus37 0
McGeary, Ross P., Vella, Peter, Mak, Jeffery Y. W., Guddat, Luke W. and Schenk, Gerhard (2009) Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorganic & Medicinal Chemistry Letters, 19 1: 163-166. doi:10.1016/j.bmcl.2008.10.125 88   16 Cited 17 times in Scopus17 0
Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013) Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 17: 6967-6984. doi:10.1021/jm400779n 41   4 Cited 6 times in Scopus6 0
Keough, Dianne T., Skinner-Adams, Tina, Jones, Malcolm K., Ng, Ai-Lin., Brereton, Ian M., Guddat, Luke W. and de Jersey, John (2006) Lead compounds for antimalarial chemotherapy: Purine base analogs discriminate between human and P-falciparum 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 49 25: 7479-7486. doi:10.1021/jm061012j 140   30 Cited 28 times in Scopus28 0
Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012) Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 7: 2555-2559. doi:10.1016/j.bmcl.2012.01.123 58   0 Cited 1 times in Scopus1 0
Ely, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012) Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 1: 19-22. doi:10.1016/j.jinorgbio.2011.09.015 60   7 Cited 6 times in Scopus6 0
Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004) Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 2: 154-162. doi:10.1016/j.abb.2004.01.008 125   34 Cited 35 times in Scopus35 0
Keough, Dianne T., Hockova, Daná, Krečmerová, Marcela, Česnek, Michal, Holý, Antonín, Naesens, Lieve, Brereton, Ian M., Winzor, Donald J., de Jersey, John and Guddat, Luke W. (2010) Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology, 173 2: 165-169. doi:10.1016/j.molbiopara.2010.05.018 50   15 Cited 16 times in Scopus16 0
Tyagi, Rajiv, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005) Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. Febs Journal, 272 2: 593-602. doi:10.1111/j.1742-4658.2004.04506.x 57   14 Cited 17 times in Scopus17 0
Naesens, Lieve, Guddat, Luke W., Keough, Dianne T., van Kuilenburg, André B. P., Meijer, Judith, Vande Voorde, Johan and Balzarini, Jan (2013) Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Molecular Pharmacology, 84 4: 615-629. doi:10.1124/mol.113.087247 35   3 Cited 5 times in Scopus5 0
Lavin, Martin F., Earl, Stephen, Birrell, Geoff, St. Pierre, Liam, Guddat, Luke W., John de Jersey and Masci, Paul (2009). Snake venom nerve growth factors. In Stephen P Mackessy (Ed.), Handbook of Venoms and Toxins of Reptiles 1st ed. (pp. 377-392) United States of America: CRC Press, Taylor & Francis Group. 103  
Wang, Jian-Guo, Li, Zheng-Ming, Ma, Zheng-Ming, Wang, Bao-Lei, Jiang, Lin, Pang, Siew Siew, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005) Structure-activity relationships for a new family of sulfonylurea herbicides. Journal of Computer-aided Molecular Design, 19 11: 801-820. doi:10.1007/s10822-005-9028-9 247   33 Cited 32 times in Scopus32 0
Duggleby, R.G., McCourt, J.A. and Guddat, Luke W. (2008) Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiology and Biochemistry, 2008 46: 309-324. 98   Cited 80 times in Scopus80
Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007) Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8 21-31. 141  
Lee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013) Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 1: 210-219. doi:10.1021/jm301501k 48   6 Cited 7 times in Scopus7 0
Cesnek, Michael, Hockova, Dana, Holy, Antonín, Dracinsky, Martin, Baszczynski, Ondřej, de Jersey, John, Keough, Dianne T. and Guddat, Luke W. (2011) Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 20 2: 1076-1089. doi:10.1016/j.bmc.2011.11.034 42   13 Cited 14 times in Scopus14 1
Hockova, Dana, Holy, Antonín, Masojidkova, Milena, Keough, Dianne T., de Jersey, John and Guddat, Luke W. (2009) Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic & Medicinal Chemistry, 17 17: 6218-6232. doi:10.1016/j.bmc.2009.07.044 47   49 Cited 49 times in Scopus49 0
Hockova, Dana, Keough, Dianne T., Janeba, Zlatko, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2012) Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 55 13: 6209-6223. doi:10.1021/jm300662d 47   16 Cited 17 times in Scopus17 0
Krecmerova, Marcela, Dracinsky, Martin, Hockova, Dana, Holy, Antonín, Keough, Dianne T. and Guddat, Luke W. (2012) Synthesis of purine N-9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry, 20 3: 1222-1230. doi:10.1016/j.bmc.2011.12.034 50   7 Cited 7 times in Scopus7 0
Duggleby, Ronald G., Pang, Siew Siew, Yu, Hongqi and Guddat, Luke W. (2003) Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data. European Journal of Biochemistry, 270 13: 2895-2904. doi:10.1046/j.1432-1033.2003.03671.x 40   48 Cited 55 times in Scopus55 0
McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014) The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76 132-144. doi:10.1016/j.ejmech.2014.02.008 35   1 Cited 2 times in Scopus2 0
Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006) The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 8: 3338-3363. doi:10.1021/cr050318f 102   203 Cited 201 times in Scopus201 0
Keough, Dianne T., Brereton, Ian M., De Jersey, John and Guddat, Luke W. (2005) The crystal structure of free human hypoxanthineguanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. Journal of Molecular Biology, 351 1: 170-181. doi:10.1016/j.jmb.2005.05.061 92   20 Cited 21 times in Scopus21 0
Baszczynski, Ondrej, Hockova, Dana, Janeba, Zlatko, Holy, Antonin, Jansa, Petr, Dracinsky, Martin, Keough, Dianne T. and Guddat, Luke W. (2013) The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. European Journal of Medicinal Chemistry, 67 81-89. doi:10.1016/j.ejmech.2013.06.032 23   3 Cited 4 times in Scopus4 1
Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010) The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 3: 565-573. doi:10.1042/BJ20101054 69   15 Cited 14 times in Scopus14 0
Millers, Emma-Karin I., Johnson, Lambro A., Birrell, Geoff W., Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2013) The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One, 8 1: e54104.1-e54104.12. doi:10.1371/journal.pone.0054104 49   3 Cited 3 times in Scopus3 2