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Trenholme, Katharine R., Brown, Christopher L., Skinner-Adams, Tina S., Stack, Colin, Lowther, Jonathan, To, Joyce, Robinson, Mark W., Donnelly, Sheila M., Dalton, John P. and Gardiner, Donald L. (2010) Aminopeptidases of malaria parasites: new targets for chemotherapy. Infectious Disorders - Drug Targets, 10 3: 217-225. doi:10.2174/187152610791163363 13   Cited 10 times in Scopus10 0
Thivierge, Karine, Mathew, Rency T., Nsangou, Desire M. M., Da Silva, Fabio, Cotton, Sophie, Skinner-Adams, Tina S., Trenholme, Katharine R., Brown, Christopher L., Stack, Colin M., Gardiner, Donald L. and Dalton, John P. (2012) Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases. Arkivoc, 2012 4: 330-346. doi:10.3998/ark.5550190.0013.424 15   1 Cited 1 times in Scopus1 0
Pinlaor, Porntip, Kaewpitoon, Natthawut, Laha, Thewarach, Sripa, Banchob, Kaewkes, Sasithorn, Morales, Maria E., Mann, Victoria H., Parriott, Sandi K., Suttiprapa, Sutas, Robinson, Mark W., To, Joyce, Dalton, John P., Loukas, Alex and Brindley, Paul J. (2009) Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini. PLoS Neglected Tropical Diseases, 3 3: e398-1-e398-15. doi:10.1371/journal.pntd.0000398 126   26 Cited 24 times in Scopus24 0
Stack, Colin M., Lowther, Jonathan, Cunningham, Eithne, Donnelly, Sheila, Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Teuscher, Franka, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Lua, Linda, Bell, Angus and Dalton, John P. (2007) Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. Journal of Biological Chemistry, 282 3: 2069-2080. doi:10.1074/jbc.M609251200 93   51 Cited 48 times in Scopus48 0
Williamson, Angela L., Brindley, Paul J., Abbenante, Giovanni, Prociv, Paul, Berry, Colin, Girdwood, Karen, Pritchard, David I., Fairlie, David P., Hotez, Peter J., Dalton, John P. and Loukas, Alex C. (2002) Cleavage of hemoglobin by hookworm cathespin D aspartic proteases and its potential contribution to host specificity. The FASEB Journal, 16 10: 1458-1460. doi:10.1096/fj.02-0181fje 66   70 0
Poreba, Marcin, McGowan, Sheena, Skinner-Adams, Tina S., Trenholme, Katharine R., Gardiner, Donald L., Whisstock, James C., To, Joyce, Salvesen, Guy S., Dalton, John P. and Drag, Marcin (2012) Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. Plos One, 7 2: e31938-1-e31938-8. doi:10.1371/journal.pone.0031938 85   10 Cited 15 times in Scopus15 0
Skinner-Adams, Tina S., Lowther, Jonathan, Teuscher, Franka, Stack, Colin M., Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Trenholme, Katharine R., Dalton, John P. and Gardiner, Donald L. (2007) Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds. Journal of Medicinal Chemistry, 50 24: 6024-6031. doi:10.1021/jm070733v 45   39 Cited 38 times in Scopus38 0
Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Stack, Colin M. and Dalton, John P. (2006) Overexpression of Leucyl Aminopeptidase in Plasmodium falciparum Parasites. Target for the antimalarial activity of bestatin. Journal of Biological Chemistry, 281 3: 1741-1745. doi:10.1074/jbc.M508955200 53   42 Cited 41 times in Scopus41 1
Gardiner, Donald L., Skinner-Adams, Tina S., Brown, Christopher L., Andrews, Katherine T., Stack, Colin M., McCarthy, James S., Dalton, John P. and Trenholme, Katharine R. (2009) Plasmodium falciparum: New molecular targets with potential for antimalarial drug development. Expert Review of Anti-Infective Therapy, 7 9: 1087-1098. doi:10.1586/ERI.09.93 55   10 Cited 13 times in Scopus13 0
Robinson, Mark W., Tort, Jose F., Lowther, Jonathan, Donnelly, Sheila M., Wong, Emily, Xu, Weibo, Stack, Colin M., Padula, Matthew, Herbert, Ben and Dalton, John P. (2008) Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: Expansion of repertoire of virulene-associated factors. Molecular and Cellular Proteomics, 7 6: 1111-1123. doi:10.1074/mcp.M700560-MCP200 22   50 Cited 53 times in Scopus53 0
Brady, Ciaran P., Dowd, Andrew J., Brindley, Paul J., Ryan, Thecla, Day, Sharon R. and Dalton, John P. (1999) Recombinant expression and localization of Schistosoma mansoni cathepsin L1 support its role in the degradation of host Hemoglobin. Infection and Immunity, 67 1: 368-374. 36   63 Cited 64 times in Scopus64
Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009) Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 3: 326-337. doi:10.1111/j.1365-2567.2008.02979.x 130   16 Cited 18 times in Scopus18 0
McGowan, Sheena, Porter, Corrine J., Lowther, Jonathan, Stack, Colin M., Golding, Sarah J., Skinner-Adams, Tina S., Trenholme, Katharine R., Teuscher, Franka, Donnelly, Sheila M., Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, DeGori, Ross, Buckle, Ashley M., Gardiner, Donald L., Whisstock, James C. and Dalton, John P. (2009) Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proceedings of the National Academy of Sciences of USA, 106 8: 2537-2542. doi:10.1073/pnas.0807398106 33   57 Cited 59 times in Scopus59 7
Skinner-Adams, Tina S., Peatey, Christopher L., Anderson, Karen, Trenholme, Katharine R., Krige, David, Brown, Christopher L., Stack, Colin, Nsangou, Desire M. M., Mathews, Rency T., Thivierge, Karine, Dalton, John P. and Gardinerd, Donald L. (2012) The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria. Antimicrobial Agents and Chemotherapy, 56 6: 3244-3249. doi:10.1128/AAC.06245-11 40   6 Cited 6 times in Scopus6 1
Sivaraman, Komagal Kannan, Oellig, Christine A., Huynh, Kitmun, Atkinson, Sarah C., Poreba, Marcin, Perugini, Matthew A., Trenholme, Katharine R., Gardiner, Donald L., Salvesen, Guy, Drag, Marcin, Dalton, John P., Whisstock, James C. and McGowan, Sheena (2012) X-ray crystal structure and specificity of the plasmodium falciparum malaria aminopeptidase PfM18AAP. Journal of Molecular Biology, 422 4: 495-507. doi:10.1016/j.jmb.2012.06.006 46   8 Cited 6 times in Scopus6 1