http://espace.library.uq.edu.au/ The University of Queensland en Fez http://blogs.law.harvard.edu/tech/rss http://espace.library.uq.edu.au/view/UQ:95490 2007-08-23T00:00:00Z Johnson, D. W. og Isbel, N. M. og Hawley, C. M. og Nicol, D. L. og Campbell, S. B. http://espace.library.uq.edu.au/view/UQ:236002 2011-03-14T00:00:00Z Yue, R. L. og Collins, T. J. og Sternbergh, C. og Ramee, S. R. og White, C. J. http://espace.library.uq.edu.au/view/UQ:192695 2010-01-14T00:00:00Z Ng, Chin Soon og Pillans, Peter I. og Johnson, David W. og Sturtevant, Joanna M. http://espace.library.uq.edu.au/view/UQ:144245 This development of pathology in conserved ovaries is defined as the residual ovary syndrome (ROS). It consists of pelvic pain, pelvic mass, dyspareunia as a single or a cluster of symptoms. It is estimated that at least 5% of patients will develop ROS and require surgery for it following hysterectomy. We describe a case of ROS in a 41-year-old woman who developed an abdominopelvic mass the size of a pregnancy of 24 weeks' gestation within 11 weeks of hysterectomy and right salpingo-oophorectomy. At laparotomy, the mass was found to be a huge benign ovarian cyst measuring 11.5 ± 11.0 ± 14.1 cm. Histology showed benign thick-walled follicular cysts. ROS can occur 'acutely', our case having the shortest latent period of onset ever reported. 2008-06-10T00:00:00Z Rane, A. og Ohizua, O. http://espace.library.uq.edu.au/view/UQ:136263 We describe the use of nitric oxide as an oxygen-sparing strategy in the context of prior bleomycin exposure. A 27-year-old male, previously treated with bleomycin for a testicular germ cell tumour, presented with severe acute respiratory distress syndrome on the second postoperative day following an extensive retroperitoneal dissection. The mechanism of bleomycin toxicity and potential benefits of nitric oxide in this situation are considered. 2008-04-24T00:00:00Z Holley, A. og Cartner, M. og Lipman, J. http://espace.library.uq.edu.au/view/UQ:146798 2008-06-06T00:00:00Z Lipman, J. og Saadia, R. http://espace.library.uq.edu.au/view/UQ:234674 2011-03-10T00:00:00Z Hordern, Matthew D. og Marwick, Thomas H. og Wood, Peter og Cooney, Louise M. og Prins, Johannes B. og Coombes, Jeff S. http://espace.library.uq.edu.au/view/UQ:259040 2011-10-23T00:00:00Z Fabro, Mauro og Szabo, Hajnalka og Terrosu, Giovanni og Avellini, Claudio og Tabuso, Maria og Fiorino, Gionata og Sorrentino, Dario http://espace.library.uq.edu.au/view/UQ:263449 Acute aortic occlusion is a rare but catastrophic disease with a high mortality rate. Severe perioperative complications could result from revascularization of infarcted muscles. Muscle cell ischaemia and massive volume cell death lead to the release of myoglobin, potassium, and lactic acid, which could be fatal if not recognised or treated early. We highlight the life-threatening adverse effects resulting from bulk tissue infarction from nontraumatic causes such as aortic occlusion followed by the metabolic sequelae of reperfusion. This is similar to the pathophysiology of traumatic crush injuries and rhabdomyolysis. The case highlights the vigorous pre-emptive treatment of acidosis and hyperkalaemia required during surgical revascularisation to potentially avert adverse surgical outcomes in acute aortic obstruction. 2011-12-14T00:00:00Z Ting, Joseph Y. og Dehdary, Arash http://espace.library.uq.edu.au/view/UQ:138982 2008-05-29T00:00:00Z Masters, S. og Mitchell, G. og Yelland, M. og O'Doherty, L. http://espace.library.uq.edu.au/view/UQ:134682 Shoulder pain is a common presentation in general practice, with approximately 1% of adults consulting a general practitioner with new shoulder pain annually.(1) The 1 month period prevalence of shoulder pain is 16%.(2) A 2005 BEACH report indicated that 0.8% of all patient encounters in general practice were due to shoulder pain.(3) Just 50% of new episodes of shoulder disorders recover within 6 months(4) rendering it a condition with likely long term consequences. The condition is associated with impaired physical and psychosocial functioning.(5). 2008-04-04T00:00:00Z Masters, Scott og O'Doherty, Lorna og Mitchell, Geoffrey K. og Yelland, Michael http://espace.library.uq.edu.au/view/UQ:278771 2012-08-09T14:06:30Z Kassam-Adams, Nancy og Palmieri, Patrick A. og Rork, Kristine og Delehanty, Douglas L. og Kenardy, Justin og Kohser, Kristen L. og Landolt, Markus A. og Le Brocque, Robyne og Marsac, Meghan L. og Meiser-Stedman, Richard og Nixon, Reginald D. V. og Bui, Eric og McGrath, Caitlin http://espace.library.uq.edu.au/view/UQ:236178 2011-03-14T00:00:00Z DeVries, James T. og White, Christopher J. og Collins, Tyrone J. og Jenkins, J. Stephen og Reilly, John P. og Grise, Mark A. og McMullan, Paul W. og Badawi, Ramy A. og Ramee, Stephen R. http://espace.library.uq.edu.au/view/UQ:160901 We report a 22-year-old man suffering from exercise-induced rhabdomyolysis of both lower legs. The patient was admitted to our department for deep vein thrombosis. Clinical examination showed diffuse erythema, swelling, and pain on palpation of both calves. Ultrasonography revealed muscle alterations. Creatine kinase plasma levels were slightly elevated. Based on these findings and on the detailed history the diagnosis of exercise-induced rhabdomyolysis was made. Exercise-induced rhabdomyolysis is an important and potentially fatal disease. Although it is a rare differential diagnosis of deep vein thrombosis, it has to be taken in consideration in patients with muscle alteration visible on ultrasonography. Early recognition and appropriate treatment are of utmost importance for a good clinical outcome. 2009-01-15T00:00:00Z Binder, B. og Soyer, H. P. og Salmhofer, W. og Kerl, H. http://espace.library.uq.edu.au/view/UQ:10673 This is a letter to the editor describing a patient with acute transverse myelitis occurring after a tetanus toxoid booster administration. Although it is possible that the patient's myelopathy occurred independently of the vaccination, the timing and absence of an alternative explanation may implicate tetanus toxoid. 2004-03-09T00:00:00Z Read, Stephen J. og Schapel, Graham J. og Pender, Michael P. http://espace.library.uq.edu.au/view/UQ:233725 2011-03-09T00:00:00Z Read, Stephen J. og Schapel, Graham J. og Pender, Michael P. http://espace.library.uq.edu.au/view/UQ:201924 2010-04-07T00:00:00Z Wainwright, Claire http://espace.library.uq.edu.au/view/UQ:285696 2012-11-15T16:03:11Z Ho, A. M. -C. og Daglish, M. R. og Dodd, P. R. og Stadlin, A. http://espace.library.uq.edu.au/view/UQ:66875 The metabolic conjugation of exogenous and endogenous carboxylic acid substrates with endogenous glucuronic acid, mediated by the uridine diphosphoglucuronosyl transferase (UGT) superfamily of enzymes, leads to the formation of acyl glucuronide metabolites. Since the late 1970s, acyl glucuronides have been increasingly identified as reactive electrophilic metabolites, capable of undergoing three reactions: intramolecular rearrangement, hydrolysis, and intermolecular reactions with proteins leading to covalent drug-protein adducts. This essential dogma has been accepted for over a decade. The key question proposed by researchers, and now the pharmaceutical industry, is: does or can the covalent modification of endogenous proteins, mediated by reactive acyl glucuronide metabolites, lead to adverse drug reactions, perhaps idiosyncratic in nature? This review evaluates the evidence for acyl glucuronide-derived perturbation of homeostasis, particularly that which might result from the covalent modification of endogenous proteins and other macromolecules. Because of the availability of acyl glucuronides for test tube/in vitro experiments, there is now a substantial literature documenting their rearrangement, hydrolysis and covalent modification of proteins in vitro. It is certain from in vitro experiments that serum albumin, dipeptidyl peptidase IV, tubulin and UGTs are covalently modified by acyl glucuronides. However, these in vitro experiments have been specifically designed to amplify any interference with a biological process in order to find biological effects. The in vivo situation is not at all clear. Certainly it must be concluded that all humans taking carboxylate drugs that form reactive acyl glucuronides will form covalent drug-protein adducts, and it must also be concluded that this in itself is normally benign. However, there is enough in vivo evidence implicating acyl glucuronides, which, when backed up by in vivo circumstantial and documented in vitro evidence, supports the view that reactive acyl glucuronides may initiate toxicity/immune responses. In summary, though acyl glucuronide-derived covalent modification of endogenous macromolecules is well-defined, the work ahead needs to provide detailed links between such modification and its possible biological consequences. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. 2007-08-15T00:00:00Z Bailey, M. J og Dickinson, R. G. http://espace.library.uq.edu.au/view/UQ:97602 2007-08-24T00:00:00Z Dickinson, R. G. og Mardon, K. og Jaggi, R. og Addison, R. S. http://espace.library.uq.edu.au/view/UQ:239593 As part of the genotoxic stress response, cells activate the transcription factor NF-κB. The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and the kinase ataxia telangiectasia mutated (ATM) act as proximal signal mediators. PARP-1 assembles a nucleoplasmic signalosome, which triggers PIASy-mediated IKKγ SUMOylation. ATM-dependent IKKγ phosphorylation and subsequent ubiquitination were implicated to activate the cytoplasmic IκB kinase (IKK) complex by unknown mechanisms. We show that activated ATM translocates in a calcium-dependent manner to cytosol and membrane fractions. Through a TRAF-binding motif, ATM activates TRAF6, resulting in Ubc13-mediated K63-linked polyubiquitin synthesis and cIAP1 recruitment. The ATM-TRAF6-cIAP1 module stimulates TAB2-dependent TAK1 phosphorylation. Both nuclear PARP-1- and cytoplasmic ATM-driven signaling branches converge at the IKK complex to catalyze monoubiquitination of IKKγ at K285. Our data indicate that exported SUMOylated IKKγ acts as a substrate. IKKγ monoubiquitination is a prerequisite for genotoxic IKK and NF-κB activation, but also promotes cytokine signaling. Copyright © 2011 Elsevier B.V. All rights reserved. 2011-04-01T00:00:00Z Hinz, Michael og Stilmann, Michael og Arslan, Seda Çöl og Khanna, Kum Kum og Dittmar, Gunnar og Scheidereit, Claus http://espace.library.uq.edu.au/view/UQ:207380 2010-07-11T00:00:00Z Wright, CM og Larsen, JE og Hayward, NK og Martins, MU og Tan, ME og Davidson, MR og Savarimuthu, SM og McLachlan, RE og Passmore, LH og Windsor, MN og Clarke, BE og Duhig, EE og Yang, IA og Bowman, RV og Fong, KM http://espace.library.uq.edu.au/view/UQ:277498 2012-07-12T00:00:00Z Podesta, JE og Griffin, MJ og Sugar, R og Squires, MS og Boddy, A og Linardopoulos, S og Pearson, ADJ og Moore, AS http://espace.library.uq.edu.au/view/UQ:146870 2008-06-06T00:00:00Z Lincoln, D. T. og Snyder, J. R. og Sinowatz, F. og Waters, M. J. http://espace.library.uq.edu.au/view/UQ:277491 2012-07-12T00:00:00Z Podesta, Jennifer E. og Sugar, Richard og Squires, Matt og Linardopoulos, Spiros og Pearson, Andrew D. J. og Moore, Andrew S. http://espace.library.uq.edu.au/view/UQ:204137 Methods: The project’s third phase utilised an action research framework to adapt performance indicators and involved: identifying a theoretical framework for evaluation; direction from steering and evaluation committees; the conduct and analyses of questionnaire information fro stakeholders; narrative interviews with practitioners and finally a critical examination for the national document. These led to a proposal to modify the Key Performance Indicators for Australian Public Mental Health Services document to suit the contextual needs of a remote service. Results: Analysis indicated that for the service to be culturally and contextually orientated the model needs to encompass activities beyond the range of clinical intervention - thus the introduction of two concurrent, intersecting dimensions of ‘Community Engagement’ and ‘Therapeutic Care’ under the key domains of service delivery as outlined in the Australian Public Mental Health Service document. These additional dimensions led to an increased match between practice standards (service expectations from people on the ground i.e. communities) and efficacy of the service (expectations from national standards). Conclusions and Implications: Two additions were made to the Key Performance Indicators for Australian Public Mental Health Services framework to capture the essential elements of service delivery for remote Aboriginal and/or Torres Strait Islander populations. 2010-04-23T00:00:00Z Santhanam, Radhika og McEwan, Alexandra og Bainbridge, Roxanne og Hunter, Ernest og Haswell-Elkins, Melissa http://espace.library.uq.edu.au/view/UQ:76088 Objective: To adapt the Family Wellbeing empowerment program, which was initially designed to support adults to take greater control and responsibility for their decisions and lives, to the needs of Indigenous school children living in remote communities. Method. At the request of two schools in remote Indigenous communities in far north Queensland, a pilot personal development and empowerment program based on the adult Family Wellbeing principles was developed, conducted and evaluated in the schools. The main aims of the program were to build personal identity and to encourage students to recognise their future potential and be more aware of their place in the community and wider society. Results: Participation in the program resulted in significant social and emotional growth for the students. Outcomes described by participating students and teachers included increased analytical and reflective skills, greater ability to think for oneself and set goals, less teasing and bullying in the school environment, and an enhanced sense of identity, friendship and,social relatedness'. Conclusion: This pilot implementation of the Family Wellbeing Program adapted for schools demonstrated the program's potential to enhance Indigenous young people's personal growth and development. Challenges remain in increasing parental/ family involvement and ensuring the program's sustainability and transferability. The team has been working with relevant stakeholders to further develop and package the School-based Family Wellbeing program for Education Queensland's New Basics curriculum framework. 2007-08-15T00:00:00Z Tsey, K. og Whiteside, M. og Daly, S. og Deemal, A. og Gibson, T. og Cadet-James, Y. og Wilson, A. og Santhanam, R. og Haswell-Elkins, M. R. http://espace.library.uq.edu.au/view/UQ:276310 2012-06-25T14:15:31Z Anderson, Vicki og Le Brocque, Robyne og Iselin, Gregory og Eren, Senem og Dob, Rian og Davern, Timothy J. og McKinlay, Lynne og Kenardy, Justin http://espace.library.uq.edu.au/view/UQ:230320 2011-02-27T00:00:00Z Carroll, Melanie L. og Yerkovich, Stephanie T. og Pritchard, Antonia L. og Davies, Janet M. og Upham, John W. http://espace.library.uq.edu.au/view/UQ:281512 We have developed a novel adaptive multi-infusion advisory system for circulatory management of critically ill patients which co-ordinates infusion adjustments to ensure safe trajectories. This system should reduce patient hospital stay and improve patient outcome by enhancing the quality of patient circulatory control; alleviating the clinical cognitive load, giving staff more time for direct patient care, while also reducing infusion adjustment errors. We have applied three derived circulatory variables which relate to the three main types of cardiovascular infusions (inotropic, vasoactive and fluid). A lumped parameter steady flow model of the human circulatory system and the effects of cardiovascular infusions was constructed for algorithm development, clinical experts providing feedback on a representative test set of simulated patients in circulatory shock. Independent self-learning fuzzy logic controllers (SLFLC) were found to give good adaptation to variable patient infusion sensitivities. A supervisory, rule-based module co-ordinates infusion adjustments to ensure safe circulatory trajectories. Monitoring of manual infusion adjustments allows timely advice and also a critiquing capability which can train junior staff and reduce infusion adjustment errors. A physical mock circulatory loop was used to construct and test our physical advisory system. Preliminary clinical results show good clinical utility of our adaptive multi-infusion advisory system. 2012-09-08T00:00:00Z Mason, David G. og Bancroft, Jayne og Fraser, John F. http://espace.library.uq.edu.au/view/UQ:122643 Alcohol and psycho-active substance misuse has far-reaching social, psychological and physical consequences. Advances in neuroimaging technology have allowed neurobiological theories of addiction to become better characterized. We describe the neurobiology of dependence, withdrawal, abstinence and craving states in alcohol, stimulant and opiate misuse. Structural neuroimaging techniques such as CT and MRI with new analytical approaches such as voxel-based morphometry have shown wide-spread changes in stimulant and opiate abuse and atrophy, particularly in the frontal lobes, in alcoholism. Functional neuroimaging techniques such as PET, SPECT and fMRI reveal altered regional cerebral activity by all drugs of abuse. The neurochemistry of addiction, particularly involving dopamine, serotonin, opiate and GABA, has been studied with PET and SPECT and similarities between all drugs of abuse have been found such as reduced dopaminergic markers. The evidence derived from these advances in neuroimaging is likely to herald the emergence of new biological treatments in this important field. 2008-01-25T00:00:00Z Lingford-Hughes, A og Davies, SJC og McIver, S og Williams, TM og Daglish, MRC og Nutt, DJ http://espace.library.uq.edu.au/view/UQ:153405 Scientific advances over the past 20 years have shown that drug addiction is a chronic, relapsing disease that results from the prolonged effects of drugs on the brain. As with many other brain diseases, addiction has embedded behavioral and social-context aspects that are important parts of the disorder itself. Therefore, the most effective treatment approaches will include biological, behavioral, and social-context components. Recognizing addiction as a chronic, relapsing brain disorder characterized by compulsive drug seeking and use can impact society's overall health and social policy strategies and help diminish the health and social costs associated with drug abuse and addiction. 2008-08-28T00:00:00Z Leshner, Alan I. http://espace.library.uq.edu.au/view/UQ:247124 2011-09-05T00:00:00Z Sengupta, Partho P. og Marwick, Thomas H. og Narula, Jagat http://espace.library.uq.edu.au/view/UQ:147891 2008-06-06T00:00:00Z Mitchell, C. A. og Jenkins, C. og Scicchitano, R. og Rubinfeld, A. http://espace.library.uq.edu.au/view/UQ:189866 2009-12-13T00:00:00Z Crawford, Darrell H. G. og Stuart, Katherine http://espace.library.uq.edu.au/view/UQ:198561 2010-03-10T00:00:00Z Stiller, Anna og Meadows, Graham http://espace.library.uq.edu.au/view/UQ:225053 Our objective was to estimate the cost of inpatient malnutrition conditional upon admitting diagnosis and recorded nutritional treatment. We analysed an anonymised administrative data set for inpatients treated in hospitals in Victoria, Australia 2003-2004. The data set included patient-level cost, clinical markers, demographic and episode variables. The data set was analysed to identify codes, which indicated the presence of malnutrition or its treatment. Linear regression was used to ascertain to what extent malnutrition affected the cost of admission. Controlling for the underlying condition and any treatment administered, recorded malnutrition is estimated to add AU $1,745 per admission. The total cost of coded malnutrition to the Victorian public hospital system in 2003-2004 was estimated to be least AU $10.7 million. Only 1.87% of inpatients were coded as malnourished. As administrative data are known to underreport the prevalence of malnutrition, our estimate represents a credible lower boundary on the true cost of inpatient malnutrition. © 2010 Springer-Verlag. 2010-12-17T00:00:00Z Rowell, David og Jackson, Terri http://espace.library.uq.edu.au/view/UQ:161361 2009-01-21T00:00:00Z Cardoso, R. og Massone, C. og Soyer, H. P. og Hofmann-Wellenhof, R. http://espace.library.uq.edu.au/view/UQ:281625 2012-09-09T14:53:49Z Eley, Diann S. og Wilkinson, David http://espace.library.uq.edu.au/view/UQ:235869 2011-03-14T00:00:00Z Osman, A.F. og Nunez, E. og Lavie, C.J. og Mehra, M.R. og Milani, R.V. http://espace.library.uq.edu.au/view/UQ:79206 Aim To test whether addition of moderation-orientated cue exposure (CE) or CE after dysphoric mood induction ( emotional CE, ECE) improved outcomes above those from cognitive-behaviour therapy alone (CBT) in people who drank when dysphoric. Design Multi-site randomized controlled trial comparing CBT with CBT + CE and CBT + ECE. Setting Out-patient rooms in academic treatment units in Brisbane and Sydney, Australia. Participants People with alcohol misuse and problems controlling consumption when dysphoric (n = 163). Those with current major depressive episode were excluded. Intervention Eight weekly 75-minute sessions of individual treatment for alcohol problems were given to all participants, with CBT elements held constant across conditions. From session 2, CBT + CE participants resisted drinking while exposed to alcohol cues, with two priming doses of their preferred beverage being given in some sessions. After an initial CE session, CBT + ECE participants recalled negative experiences before undertaking CE, to provide exposure to emotional cues of personal relevance. Measurements Alcohol consumption, related problems, alcohol expectancies, self-efficacy and depression. Results Average improvements were highly significant across conditions, with acceptable maintenance of effects over 12 months. Both treatment retention and effects on alcohol consumption were progressively weaker in CBT + CE and CBT + ECE than in CBT alone. Changes in alcohol dependence and depression did not differ across conditions. Conclusions These data do not indicate that addition of clinic-based CE to standard CBT improves outcomes. A different approach to the management of craving may be required. 2007-08-15T00:00:00Z Kavanagh, DJ og Sitharthan, G og Young, RM og Sitharthan, T og Saunders, JB og Shockley, N og Giannopoulos, V http://espace.library.uq.edu.au/view/UQ:225399 2010-12-20T00:00:00Z Tariq, M. og Morais, C. og Sulaiman, M. og Al Khader, A. http://espace.library.uq.edu.au/view/UQ:284756 We have been aware for decades – perhaps as a somewhat far-off theoretical problem – that antibiotic resistance is a threat to healthcare worldwide. However, the crisis is now here and very real. Each year in Europe alone, 25 000 deaths are directly attributed to antibiotic resistance. New antibiotics are not being produced fast enough, and resistance means we are running out of antibiotics of last resort. 2012-11-13T12:06:04Z Del Mar, Chris og Glasziou, Paul og Lowe, John B. og van Driel, Mieke L. og Hoffmann, Tammy og Beller, Elaine http://espace.library.uq.edu.au/view/UQ:244674 • There is an ongoing shortage of general practitioners in Australia, accompanied by a decline in the popularity of general practice as a career choice. • Many factors influence the career choice of junior doctors and medical students, including role models, the quality of clinical attachments during training, remuneration, and flexibility of training and working hours. • Evidence-based strategies that could increase the number of doctors choosing general practice as a career include longer and higher-quality general practice attachments during medical school and the early postgraduate years, and emphasising the positive aspects of general practice, such as flexibility. • General practice would become a more attractive choice if remuneration was in line with hospital specialties. 2011-07-27T00:00:00Z Thistlethwaite, J. E. og Leeder, S. R. og Kidd, M. R. og Shaw, T. http://espace.library.uq.edu.au/view/UQ:278238 2012-07-28T00:00:00Z Kay, Margaret og Evans, Megan http://espace.library.uq.edu.au/view/UQ:189194 2009-12-06T00:00:00Z O'Shea, S. og Johnson, D. W. http://espace.library.uq.edu.au/view/UQ:99417 2007-08-24T00:00:00Z Lloyd, C.A. http://espace.library.uq.edu.au/view/UQ:102025 2007-08-23T00:00:00Z Harris, P. G. http://espace.library.uq.edu.au/view/UQ:274929 2012-05-29T22:27:05Z Eley, D. S. og Synnott, R. og Baker, P. G. og Chater, A. B. http://espace.library.uq.edu.au/view/UQ:149547 2008-06-06T00:00:00Z Lightfoot, T. og Walker, P. J. og Jenkins, J. og Dique, T. og Cavaye, D. og Foster, W. og Blackford, J.