http://espace.library.uq.edu.au/ The University of Queensland en Fez http://blogs.law.harvard.edu/tech/rss http://espace.library.uq.edu.au/view/UQ:293462 The Demilitarised Zone (DMZ) and its adjoining areas serve not only as a geopolitical buffering zone between North and South Korea, but also as rare refuges for various animals and plants. This paper investigates conservation values of major DMZ resources and comparatively tests distance decay between contingent valuation and choice modelling. The overall conservation value for the DMZ resources per person as one-off payments was $9.06 or $34.97, respectively from the CVM and CM datasets. Research findings deny distance decay regardless of elicitation methods when the distance variable is parameterised as part of utility functions. Conversely, a segmentation-valuation approach demonstrates conflicting conclusions on distance decay and the WTP anomaly between users and non-users depending on elicitation methods. The CM results demonstrate that protection of the DMZ resources might be less important and attractive to local populations than to those in the distant regions. A direct cross-method transfer of any distance effect might not be granted. 2013-03-12T13:11:10Z Choi, Andy S. http://espace.library.uq.edu.au/view/UQ:266695 We investigate slicings of combinatorial manifolds as properly embedded co-dimension 1 submanifolds. Focus is given to the case of dimension 3, where slicings are (discrete) normal surfaces. For the cases of 2-neighborly 3-manifolds as well as quadrangulated slicings, lower bounds on the number of quadrilaterals of slicings depending on its genus g are presented. These are shown to be sharp for infinitely many values of g. Furthermore, we classify slicings of combinatorial 3-manifolds which are weakly neighborly polyhedral maps. 2012-02-02T00:00:00Z Spreer, Jonathan http://espace.library.uq.edu.au/view/UQ:298753 We investigate the quantum teleportation between a conformal detector Alice and an inertial detector Bob in de Sitter space in two schemes, (i) one uses free scalar modes and (ii) one utilizes cavity to store qubit. We show that the fidelity of the teleportation is degraded for Bob in both cases. While the fidelity-loss is due to the Gibbons-Hawking effect associated with his cosmological horizon in the scheme (i), the entanglement decreases in the scheme (ii) because the ability to entangle the cavities is reduced by the spacetime curvature. With a cutoff at Planck-scale, comparing with the standard Bunch-Davies choice, we also show that the possible Planckian physics cause extra modifications to the fidelity of the teleportation protocol in both schemes 2013-04-28T00:51:15Z Feng, Jun og Yang, Wen-Li og Zhang, Yao-Zhong og Fan, Heng http://espace.library.uq.edu.au/view/UQ:287817 In this article, we sought to isolate the processing demands of combining the concepts of modifier-noun phrases from those of other language comprehension processes. Probe reaction time (RT) was used as an indication of the processing resources required for combining concepts. Phrase frequency (as measured by Google hit rates) was used as a metric of the degree of conceptual combination required for each phrase. Participants were asked to interpret modifier-noun phrases using a sense-nonsense decision (Experiment 1) and a phrase meaning access task (Experiment 2). Experiment 2 also used a lexical decision task to activate the word’s individual meanings. Regression analyses for both experiments indicated that phrase frequency (indicating novelty) predicts a significant portion of the probe RT variance, such that low-frequency phrases required more processing resources than high-frequency phrases, when controlling for associative strength, word frequency, letter length, and lexical-semantic activation. Overall, this study indicates that conceptual combination requires processing resources beyond those of other language processes. 2012-12-23T00:57:06Z Ramm, Brentyn J. og Halford, Graeme S. http://espace.library.uq.edu.au/view/UQ:296066 Premises associated with commercial sex-including brothels, striptease clubs, sex cinemas, and sex shops-have increasingly been accepted as legitimate land uses, albeit ones whose location needs to be controlled because of assumed 'negative externalities'. However, the planning and licensing regulations excluding such premises from areas of residential land use are often predicated on assumptions of nuisance that have not been empirically substantiated. Accordingly, this paper reports on a survey of those living close to sex industry premises in New South Wales, Australia. The results suggest that although some residents have strong moral objections to sex premises, in general residents note few negative impacts on local amenity or quality of life, with distance from a premise being a poor predictor of residents' experiences of nuisance. These f ndings are considered in relation to the literatures on sexuality and space given regulation which ultimately appears to reproduce heteronormative moralities rather than respond to genuine environmental nuisances. 2013-04-07T00:02:13Z Hubbard, Phil og Boydell, Spike og Crofts, Penny og Prior, Jason og Searle, Glen http://espace.library.uq.edu.au/view/UQ:262364 2011-11-28T00:00:00Z Brown, Laurie M. og Boyce, R. R. og Tirtey, S. C. http://espace.library.uq.edu.au/view/UQ:296155 2013-04-07T00:50:08Z Sheard, J. M. og Ash, S. og Silburn, P. A. og Kerr, G. K. http://espace.library.uq.edu.au/view/UQ:289667 2013-01-22T11:39:25Z Douglas, Heather og Finnane, Mark http://espace.library.uq.edu.au/view/UQ:286486 2012-11-30T00:00:00Z Datta, Amitabha og Huang, Jui-Hsien og Clegg, Jack K. og Liu, Pei-Hsin og Chuang, Sheng-Jie http://espace.library.uq.edu.au/view/UQ:292581 Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without CPB (off-pump coronary artery bypass grafting [OPCAB]). Blood samples of 15 patients were collected preoperatively and on days 1, 3, and 5 after OPCAB. Expression of CD11b, CD18, CBRM1/5, and CD62L were assessed by flow cytometry under resting conditions and after stimulation with formyl methionyl-leucyl-phenylalanine (fMLF), and respiratory burst activity was also measured. Under resting conditions, PMN CD11b, CBRM1/5, and CD62L expressions were minimally altered by surgery. Compared with the response of preoperative PMNs, PMNs assayed on days 3 and 5 after OPCAB demonstrated a significantly blunted increase in the expression of CD11b and CBRM1/5 after fMLF, significantly diminished shedding of CD62L in response to platelet-activating factor and fMLF, and diminished superoxide production after stimulation on day 3. The alteration of PMN function after OPCAB implies that cardiac surgical trauma without CPB directly modulates host PMN physiology. 2013-03-03T00:30:53Z Edelman, J. James B. og Fung, Yoke Lin og Pennings, Gabrielle J. og Reddel, Caroline J. og Bannon, Paul G. og Bayfield, Matthew S. og Kritharides, Leonard og Fraser, John F. og Vallely, Michael P. http://espace.library.uq.edu.au/view/UQ:261125 Student success requires flexible delivery of critical concepts in interesting and interactive formats. Three online interactive tutorials were developed and implemented in the School of Geography, Planning and Environmental Management, UQ. The Academic Integrity tutorial addresses key aspects of why referencing is important, the meaning of collusion and the consequences of academic misconduct. The Referencing tutorial demonstrates the specifics of referencing using the Harvard and Chicago styles and the Graphic Presentation tutorial incorporates information on the nature of graphics and how they should be used in academic writing. The seamless design of the tutorials incorporates linear navigation, meaningful contexts, learning by doing and a thorough testing of concepts. The tutorials have improved students’ understanding of academic integrity, and how to reference correctly and present graphical information effectively and have eased the transition of students into their first year of study. 2011-11-11T00:00:00Z Peterson, Ann og Neil, David og Brander, Kathleen og Seeto, Deidre og McGrath, Dominic http://espace.library.uq.edu.au/view/UQ:294699 We investigate the effects of the pore cross-section, surface affinity and temperature on argon adsorption in different pore geometries. Three different pore cross sections were considered: cylindrical, hexagonal and triangular. We have placed particular emphasis on the condensation/evaporation (CE) pressures and the behavior of isosteric heat as a function of loading. It was found that CE is not affected by the shape of the pore cross section for a given surface area per unit volume and surface affinity. This is because the fluid-fluid interaction is the dominant factor in controlling condensation and evaporation steps. Although the pore cross section does not affect the CE behavior, strength of the adsorption potential can affect the pressures at which CE occurs. If the affinity towards the adsorbate is weak, the condensation pressure is higher because a higher pressure is required to build enough adsorbed layers before condensation can occur, and the evaporation pressure is also higher because it is easier to stretch the condensate as a result of weaker solid-fluid interactions. If the surface is sufficiently weak, the adsorbate only partially wets the surface, and this can result in unfilled pores, even when the pressure approaches the saturation vapor pressure. The study of CE behavior with temperature shows that the condensation pressure increases with temperature because a larger pressure is required to build up a sufficient number of layers before condensation can occur; similarly the evaporation pressure increases because it is easier to stretch the condensate at higher temperature. The reduction in the area of the hysteresis loop with temperature occurs because it is easier to stretch the condensate than to build-up adsorbate layers; this is seen as a faster shift of the evaporation pressure towards the condensation step. The pore shape only affects the initial behavior of the isosteric heat versus loading with the order: triangular > hexagonal > cylinder, while the isosteric heat in the CE region is not affected by the shape because it is dominated purely by the fluid-fluid interactions. 2013-03-24T01:03:50Z Wang, Yao og Do, D. D. og Herrera, L. F. og Nicholson, D. http://espace.library.uq.edu.au/view/UQ:258683 Precise knowledge of the frequency dependent electromagnetic properties of porous media is urgently nec- essary for successful utilization of high frequency electromagnetic measurement techniques for near and subsurface sensing. Thus, there is a need of systematic investigations by means of dielectric spectroscopy of unsaturated and saturated soils under controlled hydraulic conditions. In this context, two-port rod based transmission lines (R-TMLs) were characterized in the frequency range from 1 MHz to 10 GHz by combined theoretical, numerical, and experimental investigations. To analyze coupled hydraulic and dielectric soil properties a slightly plastic clay soil was investigated. There is evidence that the bound water contribution of the soil is substantially lower than expected. 2011-10-21T00:00:00Z Wagner, Norman og Scheuermann, Alexander og Schwing, Moritz og Bontitz, Frank og Kupfer, Klaus http://espace.library.uq.edu.au/view/UQ:290533 Optical sensing offers an attractive option for detection of surface biopotentials in human subjects where electromagnetically noisy environments exist or safety requirements dictate a high degree of galvanic isolation. Such circumstances may be found in modern magnetic resonance imaging systems for example. The low signal amplitude and high source impedance of typical biopotentials have made optical transduction an uncommon sensing approach. We propose a solution consisting of an electro-optic phasemodulator as a transducer, coupled to a vertical-cavity surface-emitting laser and the self-mixing signal detected via a photodiode. This configuration is physically evaluated with respect to synthesized surface electrocardiographic (EKG) signals of varying amplitudes and using differing optical feedback regimes. Optically detected EKG signals using strong optical feedback show the feasibility of this approach and indicate directions for optimization of the electro-optic transducer for improved signal to-noise ratios. This may provide a new means of biopotential detection suited for environments characterized by harsh electromagnetic interference. 2013-02-06T07:48:00Z Bakar, A. Ashrif A. og Lim, Yah Leng og Wilson, Stephen J. og Fuentes, Miguel og Bertling, Karl og Taimre, Thomas og Bosch, Thierry og Rakic, Aleksandar D. http://espace.library.uq.edu.au/view/UQ:299598 2013-05-09T15:04:07Z Campisi, Michele og Zhan, Fei og Haenggi, Peter http://espace.library.uq.edu.au/view/UQ:289996 2013-01-27T00:03:10Z Ashkanasy, Neal M. http://espace.library.uq.edu.au/view/UQ:294033 Toy models for quantum evolution in the presence of closed timelike curves have gained attention in the recent literature due to the strange effects they predict. The circuits that give rise to these effects appear quite abstract and contrived, as they require nontrivial interactions between the future and past that lead to infinitely recursive equations. We consider the special case in which there is no interaction inside the closed timelike curve, referred to as an open timelike curve (OTC), for which the only local effect is to increase the time elapsed by a clock carried by the system. Remarkably, circuits with access to OTCs are shown to violate Heisenberg’s uncertainty principle, allowing perfect state discrimination and perfect cloning of coherent states. The model is extended to wave packets and smoothly recovers standard quantum mechanics in an appropriate physical limit. The analogy with general relativistic time dilation suggests that OTCs provide a novel alternative to existing proposals for the behavior of quantum systems under gravity. 2013-03-17T01:22:48Z Pienaar, J. L. og Ralph, T. C. og Myers, C. R. http://espace.library.uq.edu.au/view/UQ:287482 2012-12-17T17:07:04Z Roberts, Jason og Lipman, Jeffrey http://espace.library.uq.edu.au/view/UQ:292166 2013-02-24T00:41:46Z Roberts, Jason A. og Lipman, Jeffrey http://espace.library.uq.edu.au/view/UQ:291568 2013-02-17T00:43:20Z Iacopi, Francesca og Walker, Glenn og Wang, Li og Malesys, Laura og Ma, Shujun og Cunning, Benjamin V. og Iacopi, Alan http://espace.library.uq.edu.au/view/UQ:298348 Habitat loss and natural catastrophes reduce the resources available to animals. Species can persist if they have access to additional resources and habitats through the processes of landscape complementation and supplementation. In arid and semi-arid ecosystems, where productivity is limited by precipitation, the impact of landscape change and prolonged drought is severe on specialist species whose range boundaries are limited by aridity. We examined the pattern of occurrence by a specialist arboreal folivore, the koala, at the periphery of its biogeographic range, in a semi-arid rangeland landscape. We used hierarchical mixed modelling to examine the effect of landscape change on koala populations and their habitat use during and after a prolonged drought. We found that the tree species and the distance of a site from water courses were the most important determinants for koala presence in these landscapes. Koalas were predominantly detected in riverine habitat along the water courses, which are primary habitat and provide refugia in times of drought and extreme heat. There was a strong positive effect from the interaction between the amount of primary and secondary habitat in the landscape, although individually, the amount of each of these habitats was not important. This shows koalas will persist in more intact landscapes. There was no difference in habitat use between dry and wet years, but we consider that it can take several wet seasons for koalas to expand into habitats away from water courses. 2013-04-26T18:25:57Z Smith, Andrew G. og McAlpine, Clive A. og Rhodes, Jonathan R. og Lunney, Daniel og Seabrook, Leonie og Baxter, Greg http://espace.library.uq.edu.au/view/UQ:296082 Alzheimer's disease (AD) and diabetes are among the most common diseases associated with ageing. The pathology of AD is strongly associated with accumulated misfolding proteins that results in neuronal dysfunction within the brain. Diabetes, on the contrary, is characterised by altered insulin signaling that results in reduced glucose uptake, metabolic suppression of energy consuming cells and conversion of glucose to fat in the liver. Despite distinguishing features, these diseases share common elements and may in fact be viewed as fundamentally similar disorders that differ in magnitude of specific traits, primarily affected tissues and time of onset. In this review, we outline the fundamental basis of each of the two diseases and highlight similarities in their pathophysiology. Further ahead we will discuss these features in relation to the development of drugs to treat these two diseases, particularly AD, for which the development of therapeutic chemicals has proven to be particularly difficult. We conclude with comments on efforts to develop a simple organism, Caenorhabditis elegans, as a genetic model to be used to study the systems biology of diabetes and AD. 2013-04-07T00:09:46Z Ahmad, Waqar http://espace.library.uq.edu.au/view/UQ:292562 2013-03-03T00:17:17Z Micaroni, Massimo og Malquori, Lorenzo http://espace.library.uq.edu.au/view/UQ:300038 2013-05-13T14:06:11Z Chang, Christina C. og Cheng, Allen C. og Chang, Anne B. http://espace.library.uq.edu.au/view/UQ:256593 This chapter addresses the latest developments in ceramic materials for use in oxygen transport membranes. Oxygen production is a multibillion dollar business with applications in clean energy, petrochemicals and metallurgical processes. The chapter describes the transport mechanisms involved and possible integration of these membranes in oxyfuel coal combustion and coal gasification. The chapter finishes with a discussion of the most appropriate membrane geometries and considerations for the development of membrane modules for industrial applications. 2011-10-18T00:00:00Z Smart, S. og Diniz da Costa, J. C. og Baumann, S. og Meulenberg, W. A. http://espace.library.uq.edu.au/view/UQ:300137 2013-05-15T08:11:28Z Burton, Benjamin A. http://espace.library.uq.edu.au/view/UQ:293927 Although the subject of ongoing incestuous abuse during adulthood has never been addressed in a systematic way in the professional literature, accounts of such cases have been appearing for many years. The Josef Fritzl case added a new impetus to reporting such abuses in the popular press. The current study presents 44 such cases from 24 countries that appeared in English-language press accounts over 5 years commencing January 2007. These cases are discussed in light of the minimal coverage of such issues in the professional literature. The results of this study suggest that cases of enduring incest are not rare and typically incorporate decades of sexual abuse, frequently result in pregnancies, and commonly incorporate ongoing violence and death threats. 2013-03-17T00:18:59Z Middleton, Warwick http://espace.library.uq.edu.au/view/UQ:255378 2011-10-12T00:00:00Z Nguyen, Anh V. http://espace.library.uq.edu.au/view/UQ:288723 2013-01-10T12:19:10Z Hoffmann, Tammy C. og Del Mar, Chris B. og Strong, Jenny og Mai, Juliana http://espace.library.uq.edu.au/view/UQ:243217 Classical vaccines incorporating live or attenuated microorganisms possess several disadvantages and cannot be applied against cancer and some pathogens. Modern vaccines utilizing immunogenic subunits derived from a particular pathogen are able to overcome these obstacles but need a specific delivery system for their efficacy. Nanotechnology has opened a new window into these delivery methodologies. A nano-sized formulation of subunit vaccines has been proven to be very effective in inducing cellular and humoral immune responses. Here, we review a number of peptide vaccine delivery strategies based on nanoparticles composed of polymers, peptides, lipids, and inorganic materials. 2011-07-04T00:00:00Z Skwarczynski, Mariusz og Toth, Istvan http://espace.library.uq.edu.au/view/UQ:298577 The black mamba snake here illustrates the structure of mambaglin-1, a pain-relieving peptide found in its venom. Thick gray lines lines represent the four disulfide bonds linking Cys1-3, 2-4, 5-6, and 7-8. The N-terminus of the 57 amino acid peptide is at the head of the snake and the C-terminus at the tail. The peptide has potential as a pharmacological probe or drug lead. 2013-04-28T00:18:32Z Craik, David J. og Schroeder, Christina I. http://espace.library.uq.edu.au/view/UQ:290877 2013-02-10T00:29:23Z Zanudin, Asfarina og Burns, Yvonne og Gray, Peter H. og Danks, Marcella og Poulsen, Leith og Watter, Pauline http://espace.library.uq.edu.au/view/UQ:299414 Peter Abu‘ofa is a key figure in the history of the South Sea Evangelical Church in the Solomon Islands. While the modern church recognises that Florence Young created the Queensland Kanaka Mission from which the SSEC grew, Abu‘ofa is remembered as the indigenous founder on Malaita Island. This paper looks at the early years of the church and the activities of Abu‘ofa on Malaita between 1894 and 1904, the year that the decision was made to close the Queensland Kanaka Mission at the end of 1906 and replace it with the South Sea Evangelical Mission, based in the Solomon Islands. Historical memory is that Abu‘ofa returned from Queensland in 1894, which is true, although he also returned again in 1895, and the circumstances are quite different from the established story. Clearly an exceptional person, what has been forgotten is his challenge to the Queensland justice system in 1894, a case which involved the last major incident of kidnapping in the Queensland labour trade. Despite his prominence, our understanding of Abu‘ofa remains frustratingly opaque. 2013-05-06T15:34:04Z Moore, Clive http://espace.library.uq.edu.au/view/UQ:294573 2013-03-22T18:50:58Z Guo, Ya-Nan og Xu, Hong-Yi og Auchterlonie, Graeme J. og Burgess, Tim og Joyce, Hannah J. og Gao, Qiang og Tan, Hark Hoe og Jagadish, Chennupati og Shu, Hai-Bo og Chen, Xiao-Shuang og Lu, Wei og Kim, Yong og Zou, Jin http://espace.library.uq.edu.au/view/UQ:255197 The importance of phosphorus nutrition for cattle grazing northern Australian rangelands has been well documented and demonstrated. Phosphorus is clearly one of the most important nutritional deficiencies, within the limitations of potential metabolizable energy intakes, of grazing cattle in the seasonally dry tropics. Nevertheless it appears that only a small proportion of cattle grazing phosphorus deficient pastures are supplemented or otherwise managed to alleviate phosphorus deficiency. Estimated requirements for dietary phosphorus by various classes of cattle grazing tropical pastures have recently been revised (CSIRO 2007). The development of faecal near infrared spectroscopy F.NIRS) allows the routine estimation of metabolizable energy and nitrogen concentrations in the diet, and thus the potential productivity, of cattle grazing northern rangelands. The concentration of phosphorus in the diet of grazing cattle can be estimated from the concentration of phosphorus in the faeces, at least in cattle not fed phosphorus supplements. Combining estimates of diet metabolizable energy, nitrogen and phosphorus allows estimation whether current needs of the animal are supplied by the diet. Phosphorus-replete cattle have substantial body reserves of phosphorus which can be mobilized, especially in late pregnancy and lactation, to alleviate a dietary deficiency. However, these body reserves need to be replenished in late lactation or post-lactation if mobilization occurs each year. Diagnosis of subclinical phosphorus deficiency in grazing cattle, and prediction of animal responses to phosphorus supplements is difficult. In growing cattle the concentration of inorganic phosphorus in blood (Pi), in the late wet or early dry season, combined with information on diet metabolizable energy and nitrogen concentrations obtained by F.NIRS, provides the most reliable test. In pregnant or lactating cows measurements of faecal phosphorus concentration and F.NIRS provide the best estimate of whether phosphorus intake meets the current needs of the animal. However, estimates of adequacy of phosphorus supply need to also consider possible mobilization of body phosphorus reserves. Indicative responses to provision of phosphorus supplements by cattle grazing pastures ranging from marginal to acute deficiency are summarized. Economic evaluation of benchmark enterprises where cattle are expected to be phosphorus deficient indicate that phosphorus supplementation is highly cost-effective. Major obstacles to more widespread adoption of phosphorus supplementation appear to be lack of knowledge and appreciation by managers of the phosphorus status of their cattle, lack of appreciation of the cost-effectiveness of a phosphorus supplementation particularly for some classes of cattle, and the practical difficulties in implementing phosphorus supplementation during the wet season. 2011-10-12T00:00:00Z Dixon, Rob og Coates, David og Holmes, Bill og English, Bernie og Rolfe, Joe http://espace.library.uq.edu.au/view/UQ:291191 2013-02-12T10:32:50Z Trost, Stewart G. og McCoy, Tara A. og Vander Veur, Stephanie S. og Mallya, Giridhar og Duffy, Meghan L. og Foster, Gary D. http://espace.library.uq.edu.au/view/UQ:262485 2011-11-29T00:00:00Z Nissen, Lisa http://espace.library.uq.edu.au/view/UQ:289782 A dual-band bandpass filter with wide and highly attenuated stopbands is designed using parallel coupled microstrip line (PCML) and stepped-impedance-resonators (SIRs). The proposed filter is composed of a pair of highly coupled PCML-SIR structure and a central resonator using a low impedance rectangular microstrip. Initially, the wide dual-band performance is achieved by creating a transmission zero between those two bands using a tightly coupled PCML-SIR with a suitable impedance ratio. Then, a low impedance resonator is placed between the pair of PCML-SIR to generate multiple resonant frequencies for a broadband performance. The simulated and measured results of those filters agree very well. The bandwidth of the first band in the developed filters extends from 1.75 GHz to 3.75 GHz with less than 0.3 dB insertion loss at the center of the band. The second band has a bandwidth that extends from 6.95 GHz to 8.75 GHz with less than 0.5 dB insertion loss at the center of that band. The stopband separating those two passband has more than 30 dB attenuation with transmission zero at 5.85 GHz. 2013-01-24T12:21:32Z Marimuthu, Jayaseelan og Abbosh, Amin M. og Henin, Bassem http://espace.library.uq.edu.au/view/UQ:295758 2013-04-04T10:37:27Z Deng, Zhou J. og Liang, Mingtao og Toth, Istvan og Monteiro, Michael og Minchin, Rodney F. http://espace.library.uq.edu.au/view/UQ:290717 Changes in ploidy have a profound and usually negative influence on cellular viability and proliferation, yet the vast majority of cancers and tumours exhibit an aneuploid karyotype. Whether this genomic plasticity is a cause or consequence of malignant transformation remains uncertain. Systemic fungal pathogens regularly develop aneuploidies in a similar manner during human infection, often far in excess of the natural rate of chromosome nondisjunction. As both processes fundamentally represent cells evolving under selective pressures, this suggests that changes in chromosome number may be a concerted mechanism to adapt to the hostile host environment. Here, we examine the mechanisms by which aneuploidy and polyploidy are generated in the fungal pathogens Candida albicans and Cryptococcus neoformans and investigate whether these represent an adaptive strategy under severe stress through the rapid generation of large-scale mutations. Insights into fungal ploidy changes, strategies for tolerating aneuploidies and proliferation during infection may yield novel targets for both antifungal and anticancer therapies. 2013-02-08T13:40:20Z Morrow, Carl A. og Fraser, James A. http://espace.library.uq.edu.au/view/UQ:298772 A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (Roundup™) and a Roundup-tolerant genetically modified variety of maize, concluding that both the herbicide and the maize varieties are toxic. Here we discuss the many errors and inaccuracies in the published article resulting in highly misleading conclusions, whose publication in the scientific literature and in the wider media has caused damage to the credibility of science and researchers in the field. We and many others have criticized the study, and in particular the manner in which the experiments were planned, implemented, analyzed, interpreted and communicated. The study appeared to sweep aside all known benchmarks of scientific good practice and, more importantly, to ignore the minimal standards of scientific and ethical conduct in particular concerning the humane treatment of experimental animals. 2013-04-28T00:55:30Z Arjo, Gemma og Portero, Manuel og Pinol, Carme og Vinas, Juan og Matias-Guiu, Xavier og Capell, Teresa og Bartholomaeus, Andrew og Parrott, Wayne og Christou, Paul http://espace.library.uq.edu.au/view/UQ:300106 2013-05-14T13:29:09Z Smith, L.A.W. og Hillman, R. og Ward, J. og Whiley, D.M. og Causer, L. og Skov, S. og Donovan, B. og Kaldor, J. og Guy, R. http://espace.library.uq.edu.au/view/UQ:282744 2012-10-04T14:44:38Z Hennig, Stefanie og Standing, Joseph F. og Staatz, Christine E. og Thomson, Alison H. http://espace.library.uq.edu.au/view/UQ:287895 Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator, which is administered to less than 10 % of patients due to a limited (4.5 h) time window of efficacy. Thus, there is an urgent need for novel therapies that can prevent or reverse the effects of stroke-induced brain injury. Recent encouraging reports have revealed that stem cells derived from human tissue, including embryonic, induced pluripotent, neural, and mesenchymal cells, can rescue injured brain tissue and improve functional recovery in experimental models of stroke. However, there are potentially major limitations to each of these types of stem cells that may ultimately prevent or restrict their use as viable mainstream treatment options for stroke patients. Conversely, stem cells derived from the placenta, such as human amnion epithelial cells (hAECs), appear to have several important advantages over other stem cell lineages, in particular their non-tumorigenic and non-immunogenic characteristics. Surprisingly, so far hAECs have received little attention as a potential stroke therapy. This brief review will firstly describe the inflammatory response and immune cell involvement following stroke, and then consider the potential for hAECs to improve stroke outcome given their unique characteristics. These actions of hAECs may involve a reduction of local inflammation and modulation of the immune response, promotion of neural recovery, differentiation into neural tissue, re-innervation of lost connections, and secretion of necessary cytokines, growth factors, hormones and/or neurotransmitters to restore cellular function. 2012-12-25T12:00:44Z Broughton, Brad R. og Lim, Rebecca og Arumugam, Thiruma V. og Drummond, Grant R. og Wallace, Euan M. og Sobey, Christopher G. http://espace.library.uq.edu.au/view/UQ:283498 2012-10-16T15:19:27Z Hatton, Anna Lucy og Rome, Keith http://espace.library.uq.edu.au/view/UQ:290939 2013-02-10T00:57:41Z Wearne, L. J. og Ko, D. og Hannan-Jones, M. og Calvert, M. http://espace.library.uq.edu.au/view/UQ:294734 2013-03-24T01:29:39Z Lee, Peter og Mori, Akihiro og Coradini, Marcia og Mori, Nobuko og Sagara, Fumi og Yamamoto, Ichiro og Rand, Jacquie S. og Arai, Toshiro http://espace.library.uq.edu.au/view/UQ:268923 2012-03-05T00:00:00Z Qian, Ma http://espace.library.uq.edu.au/view/UQ:257858 2011-10-20T00:00:00Z Powell, Joseph E. og Zietsch, Brendan P http://espace.library.uq.edu.au/view/UQ:289323 2013-01-18T13:40:22Z Collins, C. T. og Reid, J. og Makrides, M. og Lingwood, B. E. og McPhee, A. J. og Morris, S. A. og Gibson, R. A. og Ward, L. C.